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Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia

Cancer cell, 2006-10, Vol.10 (4), p.257-268

2006

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ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

Cancer cell, 2018-03, Vol.33 (3), p.495-511.e12

2018

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The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

Cancer cell, 2012-04, Vol.21 (4), p.473-487

2012

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A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia

The Journal of clinical investigation, 2020-03, Vol.130 (3), p.1217-1232

2020

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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

Cell reports (Cambridge), 2018-03, Vol.22 (13), p.3641-3659

2018

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The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression

Cancer research (Chicago, Ill.), 2010-05, Vol.70 (9), p.3833-3842

2010

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The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis

Cell, 2005-10, Vol.123 (2), p.207-218

2005

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Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential

Genes & development, 2007-11, Vol.21 (21), p.2762-2774

2007

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Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia

Cancer cell, 2015-09, Vol.28 (3), p.329-342

2015

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The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

Cancer cell, 2012-06, Vol.21 (6), p.856-856

2012

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CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1

Analytical biochemistry, 2013-11, Vol.442 (1), p.104-106

2013

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Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Cell reports (Cambridge), 2021-09, Vol.36 (12), p.109725-109725, Article 109725

2021

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Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage

Cancer cell, 2016-07, Vol.30 (1), p.5-7

2016

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Nanofluidic Allele-Specific Digital PCR Method for Quantifying IDH1 and IDH2 Mutation Burden in Acute Myeloid Leukemia

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1633, p.235

2017

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Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis

Scientific reports, 2019-03, Vol.9 (1), p.4915, Article 4915

2019

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Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

Cell reports (Cambridge), 2018-01, Vol.22 (3), p.638-652

2018

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Conserved role of FOXC1 in TNBC is parallel to FOXA1 in ER+ breast cancer

iScience, 2024-08, Vol.27 (8), p.110500, Article 110500

2024

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Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

iScience, 2023-08, Vol.26 (8), p.107319-107319, Article 107319

2023

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LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Molecular & cellular oncology, 2018-07, Vol.5 (4), p.e1481813-e1481813

2018

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AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells

HemaSphere, 2019-06, Vol.3 (3), p.e233-n/a

2019

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LSD1: biologic roles and therapeutic targeting

Epigenomics, 2016-08, Vol.8 (8), p.1103-1116

2016

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Mutant CEBPA: Priming Stem Cells for Myeloid Leukemogenesis

Cell stem cell, 2009-11, Vol.5 (5), p.453-454

2009

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First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

Journal of clinical oncology, 2020-12, Vol.38 (36), p.4260-4273

2020

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Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression

The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential

Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia

The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells

CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage

Nanofluidic Allele-Specific Digital PCR Method for Quantifying IDH1 and IDH2 Mutation Burden in Acute Myeloid Leukemia

Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

Conserved role of FOXC1 in TNBC is parallel to FOXA1 in ER+ breast cancer

Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells

LSD1: biologic roles and therapeutic targeting

Mutant CEBPA: Priming Stem Cells for Myeloid Leukemogenesis

First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

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