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A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models

PloS one, 2015-03, Vol.10 (3), p.e0122461-e0122461

2015

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

Nature neuroscience, 2006-10, Vol.9 (10), p.1231-1233

2006

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Parkinson's Disease-Associated Mutations in Leucine-Rich Repeat Kinase 2 Augment Kinase Activity

Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (46), p.16842-16847

2005

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Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism

Pharmacological research, 2011-05, Vol.63 (5), p.439-444

2011

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Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

Cardiorenal medicine, 2020-01, Vol.10 (1), p.42-50

2020

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Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

Human molecular genetics, 2011-10, Vol.20 (20), p.3933-3942

2011

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Drosophila model for LRRK2-linked parkinsonism

Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (7), p.2693-2698

2008

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Synphilin-1 binds ATP and regulates intracellular energy status

PloS one, 2014-12, Vol.9 (12), p.e115233-e115233

2014

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Leucine-Rich Repeat Kinase 2 (LRRK2) Interacts with Parkin, and Mutant LRRK2 Induces Neuronal Degeneration

Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (51), p.18676-18681

2005

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Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

Human molecular genetics, 2005-12, Vol.14 (24), p.3801-3811

2005

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CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (8), p.2897-2902

2009

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Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation

International journal of molecular sciences, 2020-06, Vol.21 (12), p.4352

2020

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Curcumin Reduced H2O2- and G2385R-LRRK2-Induced Neurodegeneration

Frontiers in aging neuroscience, 2021-10, Vol.13, p.754956-754956

2021

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Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models

Cells (Basel, Switzerland), 2021-07, Vol.10 (8), p.1850

2021

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Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

Scientific reports, 2017-07, Vol.7 (1), p.6936-7, Article 6936

2017

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LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

Neurobiology of disease, 2012-09, Vol.47 (3), p.385-392

2012

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Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (44), p.17358-17363

2007

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A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

Cells (Basel, Switzerland), 2021-02, Vol.10 (2), p.480

2021

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Transmembrane Protein 230 Mediates a Poly(ADP-ribose) Polymerase-1-Linked Apoptosis

Frontiers in aging neuroscience, 2020-08, Vol.12, p.235-235

2020

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Identification of glyceraldehyde 3-phosphate dehydrogenase sequence and expression profiles in tree shrew (Tupaia belangeri)

PloS one, 2014-06, Vol.9 (6), p.e98552-e98552

2014

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CCK Response Deficiency in Synphilin-1 Transgenic Mice

PloS one, 2015-11, Vol.10 (11), p.e0142314

2015

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Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

Neurobiology of disease, 2006-09, Vol.23 (3), p.543-551

2006

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Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice

PloS one, 2014-05, Vol.9 (5), p.e91449-e91449

2014

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Controversy of TMEM230 Associated with Parkinson’s Disease

Neuroscience, 2021-01, Vol.453, p.280-286

2021

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Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasis

Physiology & behavior, 2012-01, Vol.105 (2), p.234-241

2012

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A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Parkinson's Disease-Associated Mutations in Leucine-Rich Repeat Kinase 2 Augment Kinase Activity

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism

Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

Drosophila model for LRRK2-linked parkinsonism

Synphilin-1 binds ATP and regulates intracellular energy status

Leucine-Rich Repeat Kinase 2 (LRRK2) Interacts with Parkin, and Mutant LRRK2 Induces Neuronal Degeneration

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation

Curcumin Reduced H2O2- and G2385R-LRRK2-Induced Neurodegeneration

Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models

Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts

Transmembrane Protein 230 Mediates a Poly(ADP-ribose) Polymerase-1-Linked Apoptosis

Identification of glyceraldehyde 3-phosphate dehydrogenase sequence and expression profiles in tree shrew (Tupaia belangeri)

CCK Response Deficiency in Synphilin-1 Transgenic Mice

Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin

Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice

Controversy of TMEM230 Associated with Parkinson’s Disease

Roles of dorsomedial hypothalamic cholecystokinin signaling in the controls of meal patterns and glucose homeostasis

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