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Crystal structures of the DExH‐box RNA helicase DHX9

Acta crystallographica. Section D, Biological crystallography., 2023-11, Vol.79 (11), p.980-991

2023

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Structural Basis for Apelin Control of the Human Apelin Receptor

Structure (London), 2017-06, Vol.25 (6), p.858-866.e4

2017

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The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance

PloS one, 2016-09, Vol.11 (9), p.e0163366-e0163366

2016

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Crystal structures of human procathepsin H

PloS one, 2018-07, Vol.13 (7), p.e0200374-e0200374

2018

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From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Journal of medicinal chemistry, 2011-08, Vol.54 (16), p.5836-5857

2011

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Structural Basis for Polypyrimidine Tract Recognition by the Essential Pre-mRNA Splicing Factor U2AF65

Molecular cell, 2006-07, Vol.23 (1), p.49-59

2006

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Correction: Crystal structures of human procathepsin H

PloS one, 2019-06, Vol.14 (6), p.e0218063-e0218063

2019

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Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D

MedChemComm, 2017-06, Vol.8 (6), p.1196-1206

2017

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Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3732-3749

2016

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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6784-6802

2015

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Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

ACS chemical biology, 2016-10, Vol.11 (10), p.2734-2743

2016

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Correction to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β‑Secretase

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3218-3218

2017

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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9009-9024

2012

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Correction to Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3218-3218

2017

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Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9

SLAS discovery, 2023-12, Vol.28 (8), p.376-384

2023

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The MotA transcription factor from bacteriophage T4 contains a novel DNA‐binding domain: the ‘double wing’ motif

Molecular microbiology, 2002-03, Vol.43 (5), p.1079-1088

2002

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X-Ray Structure of a Rex-Family Repressor/NADH Complex Insights into the Mechanism of Redox Sensing

Chemistry of materials, 2005, Vol.13 (1), p.43-54

2005

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Alternative conformations at the RNA-binding surface of the N-terminal U2AF(65) RNA recognition motif

Journal of molecular biology, 2007-02, Vol.366 (3), p.703-710

2007

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Crystal structures of the DE x H-box RNA helicase DHX9

Acta crystallographica. Section D, Structural biology, 2023-11, Vol.79 (11), p.980-991

2023

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

ACS medicinal chemistry letters, 2012-11, Vol.3 (11), p.886-891

2012

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The Crystal Structure of the UvsW Helicase from Bacteriophage T4

Structure (London), 2004-04, Vol.12 (4), p.583-592

2004

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Abstract A112: Drug discovery efforts on the RNA protein methyltransferase METTL3/METTL14

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.A112-A112

2019

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Fragment-Linking Approach Using [superscript 19]F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of [beta]-Secretase

Journal of medicinal chemistry, 2016-05, Vol.59 ((8) ; 03, 2016)

2016

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Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3732-3749

2016

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Abstract B073: Characterization of selective, allosteric inhibitors of human XRN1

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.B073-B073

2023

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Crystal structures of the DExH‐box RNA helicase DHX9

Structural Basis for Apelin Control of the Human Apelin Receptor

The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance

Crystal structures of human procathepsin H

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Structural Basis for Polypyrimidine Tract Recognition by the Essential Pre-mRNA Splicing Factor U2AF65

Correction: Crystal structures of human procathepsin H

Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D

Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3

Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

Correction to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β‑Secretase

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Correction to Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9

The MotA transcription factor from bacteriophage T4 contains a novel DNA‐binding domain: the ‘double wing’ motif

X-Ray Structure of a Rex-Family Repressor/NADH Complex Insights into the Mechanism of Redox Sensing

Alternative conformations at the RNA-binding surface of the N-terminal U2AF(65) RNA recognition motif

Crystal structures of the DE x H-box RNA helicase DHX9

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

The Crystal Structure of the UvsW Helicase from Bacteriophage T4

Abstract A112: Drug discovery efforts on the RNA protein methyltransferase METTL3/METTL14

Fragment-Linking Approach Using [superscript 19]F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of [beta]-Secretase

Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Abstract B073: Characterization of selective, allosteric inhibitors of human XRN1

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