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Human Organoids for Predictive Toxicology Research and Drug Development

Frontiers in genetics, 2021-11, Vol.12, p.767621-767621

2021

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Physiological platelet aggregation assay to mitigate drug-induced thrombocytopenia using a microphysiological system

Scientific reports, 2024-06, Vol.14 (1), p.14109-11, Article 14109

2024

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Comparative analysis of neurofilament light chain levels in the serum and cerebrospinal fluid in rats subjected to partial sciatic nerve ligation

Journal of Toxicologic Pathology, 2022, pp.2022-0110

2023

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Polygenic architecture informs potential vulnerability to drug-induced liver injury

Nature medicine, 2020-10, Vol.26 (10), p.1541-1548

2020

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Blood Neurofilament Light Chain as a Potential Biomarker for Central and Peripheral Nervous Toxicity in Rats

Toxicological sciences, 2021-12, Vol.185 (1), p.10-18

2021

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Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

Toxicology in vitro, 2021-08, Vol.74, p.105159, Article 105159

2021

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Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway

BMC pharmacology & toxicology, 2021-10, Vol.22 (1), p.55-10, Article 55

2021

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Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes

Toxicology and applied pharmacology, 2019-11, Vol.383, p.114761, Article 114761

2019

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Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson’s disease monkey model

Journal of Toxicologic Pathology, 2023, Vol.36(4), pp.199-204

2023

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High-Throughput Screening to Evaluate Inhibition of Bile Acid Transporters Using Human Hepatocytes Isolated From Chimeric Mice

Toxicological sciences, 2020-02, Vol.173 (2), p.347-361

2020

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Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

Stem cell reports, 2017-02, Vol.8 (2), p.226-234

2017

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Determination of appropriate stage of human-induced pluripotent stem cell-derived cardiomyocytes for drug screening and pharmacological evaluation in vitro

Journal of biomolecular screening, 2012-10, Vol.17 (9), p.1192-1203

2012

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A novel purification method of murine embryonic stem cell- and human-induced pluripotent stem cell-derived cardiomyocytes by simple manual dissociation

Journal of biomolecular screening, 2012-06, Vol.17 (5), p.683-691

2012

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Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats

Transgenic research, 2012-08, Vol.21 (4), p.743-755

2012

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Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells

Toxicology letters, 2024-05, Vol.396, p.11-18

2024

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High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived Organoids

Gastroenterology (New York, N.Y. 1943), 2021-02, Vol.160 (3), p.831-846.e10

2021

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Reverse engineering liver buds through self-driven condensation and organization towards medical application

Developmental biology, 2016-12, Vol.420 (2), p.221-229

2016

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Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

Cell metabolism, 2019-08, Vol.30 (2), p.374-384.e6

2019

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Noninvasive system using human iPSC-derived cardiomyocytes to assess drug-induced inotropic changes

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Plasma neurofilament light chain as a potential biomarker of neurodegeneration in murine brain

Toxicology research (Cambridge), 2023-10, Vol.12 (5), p.751-755

2023

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Drug screening against complement disorders using human stem cell-derived endothelium and liver organoids

Journal of hepatology, 2020-08, Vol.73, p.S568-S569

2020

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FRI344 - Drug screening against complement disorders using human stem cell-derived endothelium and liver organoids

Journal of hepatology, 2020-08, Vol.73, p.S568-S569

2020

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The mechanism of thrombocytopenia caused by cholesterol-conjugated antisense oligonucleotides

Toxicology in vitro, 2023-06, Vol.89, p.105569-105569, Article 105569

2023

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Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson’s disease monkey model

Journal of Toxicologic Pathology, 2023, pp.2023-0010

2023

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High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids

Gastroenterology (New York, N.Y. 1943), 2020-10, Vol.160 (3), p.831-846.e10

2020

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Human Organoids for Predictive Toxicology Research and Drug Development

Physiological platelet aggregation assay to mitigate drug-induced thrombocytopenia using a microphysiological system

Comparative analysis of neurofilament light chain levels in the serum and cerebrospinal fluid in rats subjected to partial sciatic nerve ligation

Polygenic architecture informs potential vulnerability to drug-induced liver injury

Blood Neurofilament Light Chain as a Potential Biomarker for Central and Peripheral Nervous Toxicity in Rats

Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

Spontaneous recovery from sunitinib-induced disruption of sarcomere in human iPSC-cardiomyocytes and possible involvement of the Hippo pathway

Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes

Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson’s disease monkey model

High-Throughput Screening to Evaluate Inhibition of Bile Acid Transporters Using Human Hepatocytes Isolated From Chimeric Mice

Recapitulation of Clinical Individual Susceptibility to Drug-Induced QT Prolongation in Healthy Subjects Using iPSC-Derived Cardiomyocytes

Determination of appropriate stage of human-induced pluripotent stem cell-derived cardiomyocytes for drug screening and pharmacological evaluation in vitro

A novel purification method of murine embryonic stem cell- and human-induced pluripotent stem cell-derived cardiomyocytes by simple manual dissociation

Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats

Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells

High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived Organoids

Reverse engineering liver buds through self-driven condensation and organization towards medical application

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

Noninvasive system using human iPSC-derived cardiomyocytes to assess drug-induced inotropic changes

Plasma neurofilament light chain as a potential biomarker of neurodegeneration in murine brain

Drug screening against complement disorders using human stem cell-derived endothelium and liver organoids

FRI344 - Drug screening against complement disorders using human stem cell-derived endothelium and liver organoids

The mechanism of thrombocytopenia caused by cholesterol-conjugated antisense oligonucleotides

Identifying the dataset to define the optimal timing of histopathological examination for central nervous system toxicity in MPTP-induced Parkinson’s disease monkey model

High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids

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