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Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels

Annual review of pharmacology and toxicology, 2020-01, Vol.60 (1), p.219-240

2020

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Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1- d ]oxazol-2-amine (SKA-121)

Molecular pharmacology, 2017-10, Vol.92 (4), p.469-480

2017

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The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca2+-activated K+ channel KCNN4

American Journal of Physiology: Cell Physiology, 2022-09, Vol.323 (3), p.C694-C705

2022

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Enhancing Docking Accuracy with PECAN2, a 3D Atomic Neural Network Trained without Co-Complex Crystal Structures

Machine learning and knowledge extraction, 2024-03, Vol.6 (1), p.642-657

2024

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The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators

Frontiers in pharmacology, 2019-09, Vol.10, p.972-972

2019

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Mapping the binding site of NS309, a superagonistic positive gating modulator for the calcium-activated potassium channel KCa3.1

Biophysical journal, 2022-02, Vol.121 (3), p.246a-246a

2022

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Exploring the binding site and mechanism of action of NS309, a superagonistic positive gating modulator for the calcium-activated potassium channel KCa3.1

Biophysical journal, 2024-02, Vol.123 (3), p.261a-262a

2024

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Pose classification using three-dimensional atomic structure-based neural networks applied to ion channel-ligand docking

Biophysical journal, 2023-02, Vol.122 (3), p.143a-143a

2023

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Mechanism of Gating of the Intermediate-Conductance Calcium-Activated Potassium Channel (KCa3.1)

Biophysical journal, 2018-02, Vol.114 (3), p.308a-309a

2018

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Pose Classification Using Three-Dimensional Atomic Structure-Based Neural Networks Applied to Ion Channel–Ligand Docking

Journal of chemical information and modeling, 2022-05, Vol.62 (10), p.2301-2315

2022

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Structural Modeling of Full-Length KCa Channels using Rosetta

Biophysical journal, 2018-02, Vol.114 (3), p.307a-307a

2018

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Riluzole and novel naphthalenyl substituted aminothiazole derivatives prevent acute neural excitotoxic injury in a rat model of temporal lobe epilepsy

Neuropharmacology, 2023-02, Vol.224, p.109349-109349, Article 109349

2023

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The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca 2+ -activated K + channel KCNN4

American Journal of Physiology: Cell Physiology, 2022-09, Vol.323 (3), p.C694-C705

2022

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A new kCa3.1 channel activator SKA-346 boosts T-cell antitumor response in the immune suppressive microenvironment

Biophysical journal, 2022-02, Vol.121 (3), p.176a-176a

2022

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Augmenting the activity of calcium-activated potassium channel KCa3.1 revitalizes T-cell function in the immunosuppressive tumor microenvironment

Biophysical journal, 2023-02, Vol.122 (3), p.256a-256a

2023

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Structural Determinants for Selectivity of the Positive KCa Channel Gating Modulator, SKA-121

Biophysical journal, 2016-02, Vol.110 (3), p.114a-114a

2016

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Structure Assisted Design of Small Molecule KCa Channel Modulators

The FASEB journal, 2018-04, Vol.32 (S1), p.556.1-556.1

2018

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2.45 e-RMS Low-Random-Noise, 598.5 mW Low-Power, and 1.2 kfps High-Speed 2-Mp Global Shutter CMOS Image Sensor With Pixel-Level ADC and Memory

IEEE journal of solid-state circuits, 2022-04, Vol.57 (4), p.1125-1137

2022

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Rational Design of KCa Channel Activators

Shim, Heesung

2019

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Rational Design of KCa2 Channel Activators

Biophysical journal, 2017-02, Vol.112 (3), p.412a-413a

2017

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Rational Design of K Ca 2 Channel Activators

Biophysical journal, 2017-02, Vol.112 (3), p.412-413a

2017

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The Trials and Tribulations of Structure Assisted Design of K Ca Channel Activators

Frontiers in pharmacology, 2019-09, Vol.10, p.972

2019

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Are there superagonists for calcium-activated potassium channels?

Channels (Austin, Tex.), 2017-11, Vol.11 (6), p.504-506

2017

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Activation of Potassium Channel as a New Strategy to Boost Antitumour Immune Response

Biophysical journal, 2019-02, Vol.116 (3), p.249a-249a

2019

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Extracellular K + Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment

Bioelectricity, 2019-09, Vol.1 (3), p.169-179

2019

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Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels

Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1- d ]oxazol-2-amine (SKA-121)

The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca2+-activated K+ channel KCNN4

Enhancing Docking Accuracy with PECAN2, a 3D Atomic Neural Network Trained without Co-Complex Crystal Structures

The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators

Mapping the binding site of NS309, a superagonistic positive gating modulator for the calcium-activated potassium channel KCa3.1

Exploring the binding site and mechanism of action of NS309, a superagonistic positive gating modulator for the calcium-activated potassium channel KCa3.1

Pose classification using three-dimensional atomic structure-based neural networks applied to ion channel-ligand docking

Mechanism of Gating of the Intermediate-Conductance Calcium-Activated Potassium Channel (KCa3.1)

Pose Classification Using Three-Dimensional Atomic Structure-Based Neural Networks Applied to Ion Channel–Ligand Docking

Structural Modeling of Full-Length KCa Channels using Rosetta

Riluzole and novel naphthalenyl substituted aminothiazole derivatives prevent acute neural excitotoxic injury in a rat model of temporal lobe epilepsy

The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca 2+ -activated K + channel KCNN4

A new kCa3.1 channel activator SKA-346 boosts T-cell antitumor response in the immune suppressive microenvironment

Augmenting the activity of calcium-activated potassium channel KCa3.1 revitalizes T-cell function in the immunosuppressive tumor microenvironment

Structural Determinants for Selectivity of the Positive KCa Channel Gating Modulator, SKA-121

Structure Assisted Design of Small Molecule KCa Channel Modulators

2.45 e-RMS Low-Random-Noise, 598.5 mW Low-Power, and 1.2 kfps High-Speed 2-Mp Global Shutter CMOS Image Sensor With Pixel-Level ADC and Memory

Rational Design of KCa Channel Activators

Rational Design of KCa2 Channel Activators

Rational Design of K Ca 2 Channel Activators

The Trials and Tribulations of Structure Assisted Design of K Ca Channel Activators

Are there superagonists for calcium-activated potassium channels?

Activation of Potassium Channel as a New Strategy to Boost Antitumour Immune Response

Extracellular K + Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment

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