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Emerging therapeutic interventions against noise-induced hearing loss

Expert opinion on investigational drugs, 2017-01, Vol.26 (1), p.85-96

2017

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Noise‐induced cochlear F‐actin depolymerization is mediated via ROCK2/p‐ERM signaling

Journal of neurochemistry, 2015-06, Vol.133 (5), p.617-628

2015

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An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity

ChemMedChem, 2021-01, Vol.16 (2), p.335-339

2021

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Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (27), p.10984-10989

2012

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Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea

PloS one, 2013-04, Vol.8 (4), p.e61999

2013

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Inhibition of Histone Methyltransferase G9a Attenuates Noise-Induced Cochlear Synaptopathy and Hearing Loss

Journal of the Association for Research in Otolaryngology, 2019-06, Vol.20 (3), p.217-232

2019

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Prevention of noise-induced hearing loss by calpain inhibitor MDL-28170 is associated with upregulation of PI3K/Akt survival signaling pathway

Frontiers in cellular neuroscience, 2023-07, Vol.17, p.1199656

2023

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Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss

Journal of the Association for Research in Otolaryngology, 2016-08, Vol.17 (4), p.289-302

2016

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CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress

Biomedicine & pharmacotherapy, 2023-10, Vol.166, p.115399-115399, Article 115399

2023

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Aminoglycoside‐induced histone deacetylation and hair cell death in the mouse cochlea

Journal of neurochemistry, 2009-03, Vol.108 (5), p.1226-1236

2009

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Traumatic noise activates Rho-family GTPases through transient cellular energy depletion

The Journal of neuroscience, 2012-09, Vol.32 (36), p.12421-12430

2012

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Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses

Frontiers in molecular neuroscience, 2019-01, Vol.11, p.469-469

2019

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Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo

Journal of neurochemistry, 2006-10, Vol.99 (1), p.269-276

2006

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Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity

Frontiers in cellular neuroscience, 2017-10, Vol.11, p.315-315

2017

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Aspirin to Prevent Gentamicin-Induced Hearing Loss

The New England journal of medicine, 2006-04, Vol.354 (17), p.1856-1857

2006

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Increased Sensitivity to Noise-Induced Hearing Loss by Blockade of Endogenous PI3K/Akt Signaling

Journal of the Association for Research in Otolaryngology, 2015-06, Vol.16 (3), p.347-356

2015

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NF-κB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity

Journal of neuroscience research, 2005-03, Vol.79 (5), p.644-651

2005

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Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss

Frontiers in cell and developmental biology, 2021-03, Vol.9, p.648461-648461

2021

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Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals

Hearing research, 2001-05, Vol.155 (1), p.1-8

2001

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Autophagy attenuates noise-induced hearing loss by reducing oxidative stress

Antioxidants & redox signaling, 2015-05, Vol.22 (15), p.1308

2015

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Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ

Cellular and molecular life sciences : CMLS, 2022-05, Vol.79 (5), p.249-249, Article 249

2022

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Age-related auditory pathology in the CBA/J mouse

Hearing research, 2008-09, Vol.243 (1), p.87-94

2008

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Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK

The Journal of neuroscience, 2016-07, Vol.36 (28), p.7497-7510

2016

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Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics

Journal of neuroscience research, 2006-06, Vol.83 (8), p.1544-1551

2006

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Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant

Hearing research, 2000-04, Vol.142 (1), p.34-40

2000

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Emerging therapeutic interventions against noise-induced hearing loss

Noise‐induced cochlear F‐actin depolymerization is mediated via ROCK2/p‐ERM signaling

An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea

Inhibition of Histone Methyltransferase G9a Attenuates Noise-Induced Cochlear Synaptopathy and Hearing Loss

Prevention of noise-induced hearing loss by calpain inhibitor MDL-28170 is associated with upregulation of PI3K/Akt survival signaling pathway

Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss

CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress

Aminoglycoside‐induced histone deacetylation and hair cell death in the mouse cochlea

Traumatic noise activates Rho-family GTPases through transient cellular energy depletion

Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses

Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo

Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity

Aspirin to Prevent Gentamicin-Induced Hearing Loss

Increased Sensitivity to Noise-Induced Hearing Loss by Blockade of Endogenous PI3K/Akt Signaling

NF-κB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity

Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss

Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals

Autophagy attenuates noise-induced hearing loss by reducing oxidative stress

Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ

Age-related auditory pathology in the CBA/J mouse

Noise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK

Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics

Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant

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