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Targeting protein prenylation for cancer therapy

Nature reviews. Cancer, 2011-11, Vol.11 (11), p.775

2011

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Targeting protein tyrosine phosphatases for anticancer drug discovery

Current pharmaceutical design, 2010-06, Vol.16 (16), p.1843

2010

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GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

Nature communications, 2018-12, Vol.9 (1), p.5154-9, Article 5154

2018

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A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

Cancer research (Chicago, Ill.), 2013-03, Vol.73 (6), p.1922-1933

2013

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Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer

Clinical cancer research, 2021-07, Vol.27 (14), p.4012-4024

2021

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Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb-Raf-1 Interaction as a Novel Target for Metastatic Disease

Cancer research (Chicago, Ill.), 2012-01, Vol.72 (2), p.516-526

2012

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RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

Cancer research (Chicago, Ill.), 2012-10, Vol.72 (19), p.5025-5034

2012

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Development of o‑Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7392-7416

2012

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Searching for the elusive targets of farnesyltransferase inhibitors

Nature reviews. Cancer, 2003-12, Vol.3 (12), p.945-951

2003

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Oxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors

Journal of medicinal chemistry, 2013-05, Vol.56 (10), p.3783-3805

2013

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Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

Cancer research (Chicago, Ill.), 2003-03, Vol.63 (6), p.1270-1279

2003

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Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

Clinical cancer research, 2011-05, Vol.17 (9), p.2852-2862

2011

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Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis

Molecular and Cellular Biology, 2005-11, Vol.25 (21), p.9369-9382

2005

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Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1978-1998

2012

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Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth

Molecular and Cellular Biology, 2007-11, Vol.27 (22), p.8003-8014

2007

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Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Bioorganic & medicinal chemistry, 2010-08, Vol.18 (15), p.5576-5592

2010

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Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Journal of medicinal chemistry, 2008-08, Vol.51 (16), p.4948-4956

2008

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Discovery of PI-1840, a Novel Noncovalent and Rapidly Reversible Proteasome Inhibitor with Anti-tumor Activity

The Journal of biological chemistry, 2014-04, Vol.289 (17), p.11906-11915

2014

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Lysophosphatidic acid acyltransferase beta regulates mTOR signaling

PloS one, 2013-10, Vol.8 (10), p.e78632-e78632

2013

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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

Oncogene, 2000-12, Vol.19 (56), p.6584-6593

2000

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Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth

Cell cycle (Georgetown, Tex.), 2012-09, Vol.11 (17), p.3250-3259

2012

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Depletion of K-Ras promotes proteasome degradation of survivin

Cell cycle (Georgetown, Tex.), 2013-02, Vol.12 (3), p.522-532

2013

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Potent, Plasmodium-Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites: Structure−Activity Relationships of Ethylenediamine-Analogue Scaffolds and Homology Model Validation

Journal of medicinal chemistry, 2008-09, Vol.51 (17), p.5176-5197

2008

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Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT

Investigational new drugs, 2011-12, Vol.29 (6), p.1381-1389

2011

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Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

Cell cycle (Georgetown, Tex.), 2009-06, Vol.8 (12), p.1940-1951

2009

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Targeting protein prenylation for cancer therapy

Targeting protein tyrosine phosphatases for anticancer drug discovery

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation

Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer

Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb-Raf-1 Interaction as a Novel Target for Metastatic Disease

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

Development of o‑Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors

Searching for the elusive targets of farnesyltransferase inhibitors

Oxadiazole-isopropylamides as Potent and Noncovalent Proteasome Inhibitors

Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice

Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis

Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors

Geranylgeranyltransferase I Inhibitors Target RalB To Inhibit Anchorage-Dependent Growth and Induce Apoptosis and RalA To Inhibit Anchorage-Independent Growth

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

Discovery of PI-1840, a Novel Noncovalent and Rapidly Reversible Proteasome Inhibitor with Anti-tumor Activity

Lysophosphatidic acid acyltransferase beta regulates mTOR signaling

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth

Depletion of K-Ras promotes proteasome degradation of survivin

Potent, Plasmodium-Selective Farnesyltransferase Inhibitors That Arrest the Growth of Malaria Parasites: Structure−Activity Relationships of Ethylenediamine-Analogue Scaffolds and Homology Model Validation

Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT

Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells

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