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The Role of Next-Generation Sequencing in Pharmacogenetics and Pharmacogenomics

Cold Spring Harbor perspectives in medicine, 2019-02, Vol.9 (2), p.a033027

2019

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Genetic Determinants of Response to Warfarin during Initial Anticoagulation

The New England journal of medicine, 2008-03, Vol.358 (10), p.999-1008

2008

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Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters

Drug metabolism and disposition, 2014-08, Vol.42 (8), p.1268

2014

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Targeted next generation sequencing as a tool for precision medicine

BMC medical genomics, 2019-06, Vol.12 (1), p.81-81, Article 81

2019

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Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins

Circulation research, 2010-02, Vol.106 (2), p.297-306

2010

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Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care

Circulation. Cardiovascular genetics, 2013-08, Vol.6 (4), p.400

2013

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DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation

Current oncology (Toronto), 2023-01, Vol.30 (1), p.663-672

2023

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Organic Anion Transporting Polypeptide 2B1 (OATP2B1) Genetic Variants: In Vitro Functional Characterization and Association With Circulating Concentrations of Endogenous Substrates

Frontiers in pharmacology, 2021-09, Vol.12, p.713567-713567

2021

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Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation

PloS one, 2011-11, Vol.6 (11), p.e27808

2011

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Impact of pretreatment dihydropyrimidine dehydrogenase genotype‐guided fluoropyrimidine dosing on chemotherapy associated adverse events

Clinical and translational science, 2021-07, Vol.14 (4), p.1338-1348

2021

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Differences in Warfarin Pharmacodynamics and Predictors of Response Among Three Racial Populations

Clinical pharmacokinetics, 2019-08, Vol.58 (8), p.1077-1089

2019

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Interpatient Variation in Rivaroxaban and Apixaban Plasma Concentrations in Routine Care

Canadian journal of cardiology, 2017-08, Vol.33 (8), p.1036-1043

2017

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Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response

European heart journal, 2012-11, Vol.33 (22), p.2856-2864

2012

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Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy

Blood, 2011-09, Vol.118 (11), p.3163-3171

2011

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Novel variant in glycophorin c gene protects against ribavirin-induced anemia during chronic hepatitis C treatment

Biomedicine & pharmacotherapy, 2021-11, Vol.143, p.112195-112195, Article 112195

2021

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Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects

Clinical pharmacology and therapeutics, 2003-01, Vol.73 (1), p.41-50

2003

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Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity

Pharmacogenetics and genomics, 2011-03, Vol.21 (3), p.103-114

2011

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Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy

Blood, 2009-04, Vol.113 (17), p.3925-3930

2009

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Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

Clinical pharmacology and therapeutics, 2002-01, Vol.71 (1), p.11-20

2002

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Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe

Pharmacogenetics and genomics, 2008-05, Vol.18 (5), p.439-448

2008

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SLC6A3 Polymorphism Predisposes to Dopamine Overdose in Parkinson's Disease

Frontiers in neurology, 2018-08, Vol.9, p.693-693

2018

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Association of Sex With Stroke and Bleeding Risk of Apixaban and Rivaroxaban in Elderly Atrial Fibrillation Patients Using Propensity Score Weights

CJC open (Online), 2022-01, Vol.4 (1), p.56-64

2022

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Solanidine Metabolites as Diet‐Derived Biomarkers of CYP2D6 ‐Mediated Tamoxifen Metabolism in Breast Cancer Patients

Clinical pharmacology and therapeutics, 2024-07

2024

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A novel NUDT15 variant identified in Caucasian TPMT wild type patients with inflammatory bowel disease and azathioprine-related myelotoxicity

Pharmacogenetics and genomics, 2022-01, Vol.32 (1), p.39

2022

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Variant discovery using next-generation sequencing and its future role in pharmacogenetics

Pharmacogenomics, 2020-05, Vol.21 (7), p.471-486

2020

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The Role of Next-Generation Sequencing in Pharmacogenetics and Pharmacogenomics

Genetic Determinants of Response to Warfarin during Initial Anticoagulation

Ontogeny of human hepatic and intestinal transporter gene expression during childhood: age matters

Targeted next generation sequencing as a tool for precision medicine

Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins

Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care

DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation

Organic Anion Transporting Polypeptide 2B1 (OATP2B1) Genetic Variants: In Vitro Functional Characterization and Association With Circulating Concentrations of Endogenous Substrates

Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation

Impact of pretreatment dihydropyrimidine dehydrogenase genotype‐guided fluoropyrimidine dosing on chemotherapy associated adverse events

Differences in Warfarin Pharmacodynamics and Predictors of Response Among Three Racial Populations

Interpatient Variation in Rivaroxaban and Apixaban Plasma Concentrations in Routine Care

Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response

Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy

Novel variant in glycophorin c gene protects against ribavirin-induced anemia during chronic hepatitis C treatment

Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects

Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity

Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe

SLC6A3 Polymorphism Predisposes to Dopamine Overdose in Parkinson's Disease

Association of Sex With Stroke and Bleeding Risk of Apixaban and Rivaroxaban in Elderly Atrial Fibrillation Patients Using Propensity Score Weights

Solanidine Metabolites as Diet‐Derived Biomarkers of CYP2D6 ‐Mediated Tamoxifen Metabolism in Breast Cancer Patients

A novel NUDT15 variant identified in Caucasian TPMT wild type patients with inflammatory bowel disease and azathioprine-related myelotoxicity

Variant discovery using next-generation sequencing and its future role in pharmacogenetics

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