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Heme Oxygenase Gene Targeting to Adipocytes Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet

Hypertension (Dallas, Tex. 1979), 2012-08, Vol.60 (2), p.467-475

2012

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Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice

The Journal of pharmacology and experimental therapeutics, 2009-12, Vol.331 (3), p.906-916

2009

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20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo

The Journal of pharmacology and experimental therapeutics, 2014-03, Vol.348 (3), p.442-451

2014

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Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy

Journal of the American Society of Nephrology, 2015-03, Vol.26 (3), p.597-610

2015

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Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes

Journal of lipid research, 2013-03, Vol.54 (3), p.786-793

2013

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CYP4A2-Induced Hypertension Is 20-Hydroxyeicosatetraenoic Acid- and Angiotensin II-Dependent

Hypertension (Dallas, Tex. 1979), 2010-11, Vol.56 (5), p.871-878

2010

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EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels

Prostaglandins & other lipid mediators, 2012-08, Vol.98 (3-4), p.133-142

2012

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Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects

The Journal of pharmacology and experimental therapeutics, 2006-12, Vol.319 (3), p.1144-1152

2006

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Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid

Current opinion in nephrology and hypertension, 2017-03, Vol.26 (2), p.74-82

2017

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Vascular actions of 20-HETE

Prostaglandins & other lipid mediators, 2015-07, Vol.120, p.9-16

2015

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20-HETE and Blood Pressure Regulation: Clinical Implications

Cardiology in review, 2014-01, Vol.22 (1), p.1-12

2014

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EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension

Hypertension (Dallas, Tex. 1979), 2021-04, Vol.77 (4), p.1399-1411

2021

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CYP2J2 Targeting to Endothelial Cells Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet by Reprogramming Adipocyte Phenotype

Hypertension (Dallas, Tex. 1979), 2014-12, Vol.64 (6), p.1352-1361

2014

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Structure‐Function Relationship of the 20‐HETE‐GPR75 pairing: Development and characterization of agonist, partial agonists, and receptor blockers

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells

American journal of physiology. Heart and circulatory physiology, 2019-06, Vol.316 (6), p.H1468-H1479

2019

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Regulation of cyclooxygenase by the heme-heme oxygenase system in microvessel endothelial cells

The Journal of pharmacology and experimental therapeutics, 2002-01, Vol.300 (1), p.188-194

2002

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Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension

Vascular pharmacology, 2023-12, Vol.153, p.107235-107235, Article 107235

2023

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Heme oxygenase‐2 deletion impairs macrophage function: implication in wound healing

The FASEB journal, 2015-01, Vol.29 (1), p.105-115

2015

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Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

GeroScience, 2020-04, Vol.42 (2), p.409-428

2020

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20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition

American journal of physiology. Heart and circulatory physiology, 2016-05, Vol.310 (9), p.H1107-H1117

2016

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Cytochrome P450-Dependent Eicosapentaenoic Acid Metabolites Are Novel BK Channel Activators

Hypertension (Dallas, Tex. 1979), 2002-02, Vol.39 (2, Part 2 Suppl), p.609-613

2002

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Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure

American journal of physiology. Heart and circulatory physiology, 2014-04, Vol.306 (8), p.H1146-H1153

2014

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20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond

Advances in pharmacology (1990), 2023, Vol.97, p.229-255

2023

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Heme Oxygenase Attenuates Angiotensin II-Mediated Increase in Cyclooxygenase-2 Activity in Human Femoral Endothelial Cells

Hypertension (Dallas, Tex. 1979), 2003-03, Vol.41 (3, Part 2 Suppl), p.715-719

2003

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IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging

GeroScience, 2021-04, Vol.43 (2), p.901-911

2021

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Heme Oxygenase Gene Targeting to Adipocytes Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet

Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice

20-HETE regulates the angiogenic functions of human endothelial progenitor cells and contributes to angiogenesis in vivo

Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy

Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes

CYP4A2-Induced Hypertension Is 20-Hydroxyeicosatetraenoic Acid- and Angiotensin II-Dependent

EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects

Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid

Vascular actions of 20-HETE

20-HETE and Blood Pressure Regulation: Clinical Implications

EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension

CYP2J2 Targeting to Endothelial Cells Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet by Reprogramming Adipocyte Phenotype

Structure‐Function Relationship of the 20‐HETE‐GPR75 pairing: Development and characterization of agonist, partial agonists, and receptor blockers

CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells

Regulation of cyclooxygenase by the heme-heme oxygenase system in microvessel endothelial cells

Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension

Heme oxygenase‐2 deletion impairs macrophage function: implication in wound healing

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting cognitive function in mice

20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition

Cytochrome P450-Dependent Eicosapentaenoic Acid Metabolites Are Novel BK Channel Activators

Soluble epoxide hydrolase-dependent regulation of myogenic response and blood pressure

20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond

Heme Oxygenase Attenuates Angiotensin II-Mediated Increase in Cyclooxygenase-2 Activity in Human Femoral Endothelial Cells

IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging

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