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Palladium-Catalyzed Asymmetric Allylic Alkylation of Ketone Enolates

Chemistry : a European journal, 2005-01, Vol.11 (1), p.174-184

2005

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Antibody–drug conjugates: current status and future directions

Drug discovery today, 2014-07, Vol.19 (7), p.869-881

2014

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Exploiting the Pd- and Ru-Catalyzed Cycloisomerizations: Enantioselective Total Synthesis of (+)-Allocyathin B2

Journal of the American Chemical Society, 2005-07, Vol.127 (29), p.10259-10268

2005

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An Asymmetric Synthesis of Hamigeran B via a Pd Asymmetric Allylic Alkylation for Enantiodiscrimination

Journal of the American Chemical Society, 2004-04, Vol.126 (14), p.4480-4481

2004

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Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3224-3229

2008

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Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3518-3538

2022

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Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties

Journal of medicinal chemistry, 2018-08, Vol.61 (16), p.7168-7188

2018

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Cyclic 1,2-Diketones as Building Blocks for Asymmetric Synthesis of Cycloalkenones

Journal of the American Chemical Society, 2000-04, Vol.122 (15), p.3785-3786

2000

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Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4058-4084

2022

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Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.946-979

2018

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Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (15), p.3937-3942

2006

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Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads

Bioorganic & medicinal chemistry letters, 2017-12, Vol.27 (23), p.5267-5271

2017

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Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings

ACS medicinal chemistry letters, 2021-10, Vol.12 (10), p.1605-1612

2021

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Palladium-Catalyzed Asymmetric Alkylation of Ketone Enolates

Journal of the American Chemical Society, 1999-07, Vol.121 (28), p.6759-6760

1999

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Intramolecular Palladium-Catalyzed Allylic Alkylation: Enantio- and Diastereoselective Synthesis of [2.2.2] Bicycles

Organic letters, 2002-10, Vol.4 (20), p.3427-3430

2002

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Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor

ACS medicinal chemistry letters, 2019-01, Vol.10 (1), p.67-73

2019

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Palladium-Catalyzed Asymmetric Allylic Alkylation of Barbituric Acid Derivatives: Enantioselective Syntheses of Cyclopentobarbital and Pentobarbital

Journal of organic chemistry, 2000-03, Vol.65 (5), p.1569-1573

2000

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Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains

ACS medicinal chemistry letters, 2018-02, Vol.9 (2), p.89-93

2018

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Discovery of N‑Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties

ACS medicinal chemistry letters, 2018-05, Vol.9 (5), p.446-451

2018

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Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists

ACS medicinal chemistry letters, 2018-01, Vol.9 (1), p.17-22

2018

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Palladium-Catalyzed Asymmetric Allylic Alkylation of α-Aryl Ketones

Angewandte Chemie (International ed.), 2002-09, Vol.41 (18), p.3492-3495

2002

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Improved conditions for converting sterically hindered amides to 1,5-disubstituted tetrazoles

Tetrahedron letters, 2010-03, Vol.51 (10), p.1404-1406

2010

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Total Synthesis of (+)-Allocyathin B2

Journal of the American Chemical Society, 2005-03, Vol.127 (9), p.2844-2845

2005

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Palladium-Catalyzed Asymmetric Allylic Alkylation of Ketone Enolates

Antibody–drug conjugates: current status and future directions

Exploiting the Pd- and Ru-Catalyzed Cycloisomerizations: Enantioselective Total Synthesis of (+)-Allocyathin B2

An Asymmetric Synthesis of Hamigeran B via a Pd Asymmetric Allylic Alkylation for Enantiodiscrimination

Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties

Cyclic 1,2-Diketones as Building Blocks for Asymmetric Synthesis of Cycloalkenones

Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles

Discovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Macrocyclic pyrrolobenzodiazepine dimers as antibody-drug conjugate payloads

Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings

Palladium-Catalyzed Asymmetric Alkylation of Ketone Enolates

Intramolecular Palladium-Catalyzed Allylic Alkylation: Enantio- and Diastereoselective Synthesis of [2.2.2] Bicycles

Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor

Palladium-Catalyzed Asymmetric Allylic Alkylation of Barbituric Acid Derivatives: Enantioselective Syntheses of Cyclopentobarbital and Pentobarbital

Synthesis of Novel Tetrahydroisoquinoline CXCR4 Antagonists with Rigidified Side-Chains

Discovery of N‑Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties

Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists

Palladium-Catalyzed Asymmetric Allylic Alkylation of α-Aryl Ketones

Improved conditions for converting sterically hindered amides to 1,5-disubstituted tetrazoles

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

Total Synthesis of (+)-Allocyathin B2

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