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Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1352

2003

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Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.17

2010

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Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1300

2003

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Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

Drug metabolism and disposition, 2001-01, Vol.29 (1), p.70

2001

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Pyrene·Pyrene Complexes at the Active Site of Cytochrome P450 3A4: Evidence for a Multiple Substrate Binding Site

Journal of the American Chemical Society, 2002-10, Vol.124 (40), p.11866-11867

2002

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Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes

Drug metabolism and disposition, 2004-05, Vol.32 (5), p.473

2004

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Covalent Alteration of the CYP3A4 Active Site: Evidence for Multiple Substrate Binding Domains

Archives of biochemistry and biophysics, 2001-07, Vol.391 (1), p.49-55

2001

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Heterotropic modulation of sulfotransferase 2A1 activity by celecoxib: product ratio switching of ethynylestradiol sulfation

Drug metabolism and disposition, 2004-11, Vol.32 (11), p.1260

2004

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Mechanism-Based Inactivation of Cytochrome P450 2B1 by 7-Ethynylcoumarin: Verification of Apo-P450 Adduction by Electrospray Ion Trap Mass Spectrometry

Chemical research in toxicology, 2000-04, Vol.13 (4), p.262-270

2000

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Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity

Archives of biochemistry and biophysics, 2005-06, Vol.438 (1), p.21-28

2005

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Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol

Drug metabolism and disposition, 2004-11, Vol.32 (11), p.1299

2004

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Catalytic turnover of pyrene by CYP3A4: Evidence that cytochrome b 5 directly induces positive cooperativity

Archives of biochemistry and biophysics, 2005-06, Vol.438 (1), p.21-28

2005

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Topological alteration of the CYP3A4 active site by the divalent cation Mg(2+)

Drug metabolism and disposition, 2000-10, Vol.28 (10), p.1198

2000

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Abstract B254: Extended target-coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.B254-B254

2009

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Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site

Journal of the American Chemical Society, 2002-10, Vol.124 (40), p.11866-11867

2002

Volltextzugriff (PDF)

Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

Advances in experimental medicine and biology, 2001, Vol.500, p.347

2001

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CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

Nature neuroscience, 2022-11, Vol.25 (11), p.1528

2022

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Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Nature communications, 2022-11, Vol.13 (1), p.6581-6581, Article 6581

2022

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Association of insurance status and ethnicity with cancer stage at diagnosis for 12 cancer sites: a retrospective analysis

The lancet oncology, 2008-03, Vol.9 (3), p.222-231

2008

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Large perturbations of the carbon cycle during recovery from the end-Permian extinction

Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5683), p.506-509

2004

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Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies

JAMA pediatrics, 2020-07, Vol.174 (7), p.e200593

2020

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A CHO stable pool production platform for rapid clinical development of trimeric SARS‐CoV‐2 spike subunit vaccine antigens

Biotechnology and bioengineering, 2023-07, Vol.120 (7), p.1746-1761

2023

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Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel

The New England journal of medicine, 2021-12, Vol.385 (25), p.e90-e90

2021

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Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor

Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans

Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro

Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

Pyrene·Pyrene Complexes at the Active Site of Cytochrome P450 3A4: Evidence for a Multiple Substrate Binding Site

Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation

Cytochrome P450 2C8 (CYP2C8)-mediated hydroxylation of an endothelin ETA receptor antagonist in human liver microsomes

Covalent Alteration of the CYP3A4 Active Site: Evidence for Multiple Substrate Binding Domains

Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors

Heterotropic modulation of sulfotransferase 2A1 activity by celecoxib: product ratio switching of ethynylestradiol sulfation

Mechanism-Based Inactivation of Cytochrome P450 2B1 by 7-Ethynylcoumarin: Verification of Apo-P450 Adduction by Electrospray Ion Trap Mass Spectrometry

Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity

Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol

Catalytic turnover of pyrene by CYP3A4: Evidence that cytochrome b 5 directly induces positive cooperativity

Topological alteration of the CYP3A4 active site by the divalent cation Mg(2+)

Abstract B254: Extended target-coverage by selective Chk1 inhibitors enhances pharmacodynamic inhibition of Chk1 signaling and antitumor activity in vivo

Pyrene.pyrene complexes at the active site of cytochrome P450 3A4: evidence for a multiple substrate binding site

Triazolam substrate inhibition: evidence of competition for heme-bound reactive oxygen within the CYP3A4 active site

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Association of insurance status and ethnicity with cancer stage at diagnosis for 12 cancer sites: a retrospective analysis

Large perturbations of the carbon cycle during recovery from the end-Permian extinction

Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies

A CHO stable pool production platform for rapid clinical development of trimeric SARS‐CoV‐2 spike subunit vaccine antigens

Effectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel

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