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Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins

Molecules (Basel, Switzerland), 2019-11, Vol.24 (23), p.4357

Schöneich, Christian

2019

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Thiyl radicals and induction of protein degradation

Free radical research, 2016-02, Vol.50 (2), p.143-149

Schöneich, Christian

2016

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Oxidation and Inactivation of SERCA by Selective Reaction of Cysteine Residues with Amino Acid Peroxides

Chemical research in toxicology, 2007-10, Vol.20 (10), p.1462-1469

2007

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Visible Light Induces Site-Specific Oxidative Heavy Chain Fragmentation of a Monoclonal Antibody (IgG1) Mediated by an Iron(III)-Containing Histidine Buffer

Molecular pharmaceutics, 2023-01, Vol.20 (1), p.650-662

2023

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Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

Pharmaceutical research, 2014-03, Vol.31 (3), p.541-553

2014

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Chemical degradation of proteins in the solid state with a focus on photochemical reactions

Advanced drug delivery reviews, 2015-10, Vol.93, p.2-13

2015

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Tyrosine modifications in aging

Antioxidants & redox signaling, 2012-12, Vol.17 (11), p.1571-1579

2012

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Cysteine residues as catalysts for covalent peptide and protein modification: a role for thiyl radicals?

Biochemical Society transactions, 2011-10, Vol.39 (5), p.1254-1259

Schöneich, Christian

2011

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Low-Temperature NMR Characterization of Reaction of Sodium Pyruvate with Hydrogen Peroxide

The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory, 2015-02, Vol.119 (6), p.966-977

2015

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Azocompounds as generators of defined radical species: Contributions and challenges for free radical research

Free radical biology & medicine, 2020-11, Vol.160, p.78-91

2020

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Protein modification in aging: An update

Experimental gerontology, 2006-09, Vol.41 (9), p.807-812

Schöneich, Christian

2006

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Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways

Free radical biology & medicine, 2015-03, Vol.80, p.145-147

2015

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Protein thiyl radical reactions and product formation: a kinetic simulation

Free radical biology & medicine, 2015-03, Vol.80, p.158-163

2015

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Do Not Drop: Mechanical Shock in Vials Causes Cavitation, Protein Aggregation, and Particle Formation

Journal of pharmaceutical sciences, 2015-02, Vol.104 (2), p.602-611

2015

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Proteomic approaches to analyze protein tyrosine nitration

Antioxidants & redox signaling, 2013-10, Vol.19 (11), p.1247-1256

2013

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Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry

mAbs, 2024-12, Vol.16 (1), p.2395503

2024

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Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes

Apoptosis (London), 2014, Vol.19 (1), p.42-57

2014

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Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release

Journal of pharmaceutical sciences, 2012-03, Vol.101 (3), p.946-954

2012

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Effect of Conformation on the Photodegradation of Trp- And Cystine-Containing Cyclic Peptides: Octreotide and Somatostatin

Molecular pharmaceutics, 2014-10, Vol.11 (10), p.3537-3546

2014

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Mechanisms of Protein Damage Induced by Cysteine Thiyl Radical Formation

Chemical research in toxicology, 2008-06, Vol.21 (6), p.1175-1179

Schoeneich, Christian

2008

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Sequence-Specific Formation of d‑Amino Acids in a Monoclonal Antibody during Light Exposure

Molecular pharmaceutics, 2014-11, Vol.11 (11), p.4291-4297

2014

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Chemical Modifications in Aggregates of Recombinant Human Insulin Induced by Metal-Catalyzed Oxidation: Covalent Cross-Linking via Michael Addition to Tyrosine Oxidation Products

Pharmaceutical research, 2012-08, Vol.29 (8), p.2276-2293

2012

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Reversible Hydrogen Transfer Reactions in Thiyl Radicals From Cysteine and Related Molecules: Absolute Kinetics and Equilibrium Constants Determined by Pulse Radiolysis

The journal of physical chemistry. B, 2012-05, Vol.116 (18), p.5329-5341

2012

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SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

The Journal of clinical investigation, 2008-02, Vol.118 (2), p.659-670

2008

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Reversible Hydrogen Transfer Reactions of Cysteine Thiyl Radicals in Peptides: the Conversion of Cysteine into Dehydroalanine and Alanine, and of Alanine into Dehydroalanine

The journal of physical chemistry. B, 2011-10, Vol.115 (42), p.12287-12305

2011

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Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins

Thiyl radicals and induction of protein degradation

Oxidation and Inactivation of SERCA by Selective Reaction of Cysteine Residues with Amino Acid Peroxides

Visible Light Induces Site-Specific Oxidative Heavy Chain Fragmentation of a Monoclonal Antibody (IgG1) Mediated by an Iron(III)-Containing Histidine Buffer

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

Chemical degradation of proteins in the solid state with a focus on photochemical reactions

Tyrosine modifications in aging

Cysteine residues as catalysts for covalent peptide and protein modification: a role for thiyl radicals?

Low-Temperature NMR Characterization of Reaction of Sodium Pyruvate with Hydrogen Peroxide

Azocompounds as generators of defined radical species: Contributions and challenges for free radical research

Protein modification in aging: An update

Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways

Protein thiyl radical reactions and product formation: a kinetic simulation

Do Not Drop: Mechanical Shock in Vials Causes Cavitation, Protein Aggregation, and Particle Formation

Proteomic approaches to analyze protein tyrosine nitration

Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry

Apoptosis in differentiating C2C12 muscle cells selectively targets Bcl-2-deficient myotubes

Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release

Effect of Conformation on the Photodegradation of Trp- And Cystine-Containing Cyclic Peptides: Octreotide and Somatostatin

Mechanisms of Protein Damage Induced by Cysteine Thiyl Radical Formation

Sequence-Specific Formation of d‑Amino Acids in a Monoclonal Antibody during Light Exposure

Chemical Modifications in Aggregates of Recombinant Human Insulin Induced by Metal-Catalyzed Oxidation: Covalent Cross-Linking via Michael Addition to Tyrosine Oxidation Products

Reversible Hydrogen Transfer Reactions in Thiyl Radicals From Cysteine and Related Molecules: Absolute Kinetics and Equilibrium Constants Determined by Pulse Radiolysis

SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

Reversible Hydrogen Transfer Reactions of Cysteine Thiyl Radicals in Peptides: the Conversion of Cysteine into Dehydroalanine and Alanine, and of Alanine into Dehydroalanine

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