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NOX toolbox: validating the role of NADPH oxidases in physiology and disease

Cellular and molecular life sciences : CMLS, 2012-07, Vol.69 (14), p.2327-2343

2012

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NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

Circulation (New York, N.Y.), 2013-05, Vol.127 (18), p.1888-1902

2013

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Network medicine for disease module identification and drug repurposing with the NeDRex platform

Nature communications, 2021-11, Vol.12 (1), p.6848-6848, Article 6848

2021

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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

Nature reviews. Drug discovery, 2006-09, Vol.5 (9), p.755-768

2006

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Molecular networks in Network Medicine: Development and applications

Wiley interdisciplinary reviews. Mechanisms of disease, 2020-11, Vol.12 (6), p.e1489-n/a

2020

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Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

Diabetologia, 2016-02, Vol.59 (2), p.379-389

2016

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NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype

PLoS biology, 2020-11, Vol.18 (11), p.e3000885

2020

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Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis

Scientific reports, 2022-07, Vol.12 (1), p.11570-11570, Article 11570

2022

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Un-biased housekeeping gene panel selection for high-validity gene expression analysis

Scientific reports, 2022-07, Vol.12 (1), p.12324-12324, Article 12324

2022

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The oxidative stress theory of disease: levels of evidence and epistemological aspects

British journal of pharmacology, 2017-06, Vol.174 (12), p.1784-1796

2017

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Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology

Pharmaceuticals (Basel, Switzerland), 2018-06, Vol.11 (3), p.61

2018

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From single drug targets to synergistic network pharmacology in ischemic stroke

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (14), p.7129-7136

2019

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Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease

Scientific reports, 2020-06, Vol.10 (1), p.10012, Article 10012

2020

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Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Diabetologia, 2017-05, Vol.60 (5), p.927-937

2017

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Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Journal of the American Society of Nephrology, 2014-06, Vol.25 (6), p.1237-1254

2014

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On the Clinical Pharmacology of Reactive Oxygen Species

Pharmacological reviews, 2020-10, Vol.72 (4), p.801-828

2020

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NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (46), p.12315-12320

2017

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E. coli gene regulatory networks are inconsistent with gene expression data

Nucleic acids research, 2019-01, Vol.47 (1), p.85-92

2019

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Reactive Oxygen Species: Network Pharmacology and Therapeutic Applications

1st Edition 2021, 2021

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Translating the oxidative stress hypothesis into the clinic: NOX versus NOS

Journal of molecular medicine (Berlin, Germany), 2009-11, Vol.87 (11), p.1071-1076

2009

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Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells

PloS one, 2011-08, Vol.6 (8), p.e23596-e23596

2011

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The End of Medicine As We Know It - and Why Your Health Has a Future

Schmidt, Harald H. H. W

1, 2022

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Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition

Hypertension (Dallas, Tex. 1979), 2010-09, Vol.56 (3), p.490-497

2010

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Network pharmacology: curing causal mechanisms instead of treating symptoms

Trends in pharmacological sciences (Regular ed.), 2022-02, Vol.43 (2), p.136-150

2022

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NOX toolbox: validating the role of NADPH oxidases in physiology and disease

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

Network medicine for disease module identification and drug repurposing with the NeDRex platform

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

Molecular networks in Network Medicine: Development and applications

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype

Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis

Un-biased housekeeping gene panel selection for high-validity gene expression analysis

The oxidative stress theory of disease: levels of evidence and epistemological aspects

Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology

From single drug targets to synergistic network pharmacology in ischemic stroke

Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease

Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

On the Clinical Pharmacology of Reactive Oxygen Species

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage

E. coli gene regulatory networks are inconsistent with gene expression data

Reactive Oxygen Species: Network Pharmacology and Therapeutic Applications

Translating the oxidative stress hypothesis into the clinic: NOX versus NOS

Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells

The End of Medicine As We Know It - and Why Your Health Has a Future

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration

Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX1/2 Is Reversed by NADPH Oxidase Inhibition

Network pharmacology: curing causal mechanisms instead of treating symptoms

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