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Small molecules and their impact in drug discovery: A perspective on the occasion of the 125th anniversary of the Bayer Chemical Research Laboratory

Drug discovery today, 2022-06, Vol.27 (6), p.1560-1574

2022

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Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease

American journal of physiology. Renal physiology, 2021-01, Vol.320 (1), p.F61-F73

2021

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Cardiac output improvement by pecavaptan: a novel dual‐acting vasopressin V1a/V2 receptor antagonist in experimental heart failure

European journal of heart failure, 2021-05, Vol.23 (5), p.743-750

2021

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Pharmacological Inhibition of Vanin 1 Is Not Protective in Models of Acute and Chronic Kidney Disease: PO2372

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.721-721

2020

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Stereoselective Mukaiyama-Michael/Michael/Aldol Domino Cyclization as the Key Step in the Synthesis of Pentasubstituted Arenes: An Efficient Access to Highly Active Inhibitors of Cholesteryl Ester Transfer Protein (CETP)

Angewandte Chemie (International ed.), 1999-11, Vol.38 (22), p.3373-3375

1999

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Vascular Protection and Decongestion Without Renin-Angiotensin-Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist

Journal of cardiovascular pharmacology, 2019-07, Vol.74 (1), p.44-52

2019

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Synthesis of Optically Active 4-Substituted 2-Aminobutyrolactones and Homoserines by Combined Aldol/Photocyclization Reactions of Chromium Aminocarbene Complexes

Journal of the American Chemical Society, 1994-11, Vol.116 (22), p.9927-9934

1994

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Cholesteryl ester transfer protein and its inhibition

Cellular and molecular life sciences : CMLS, 2010-09, Vol.67 (18), p.3139-3149

2010

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Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

Drug discovery today, 2006-02, Vol.11 (3-4), p.175-180

2006

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Novel tetrahydrochinoline derived CETP inhibitors

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1740-1743

2010

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In Silico ADMET Traffic Lights as a Tool for the Prioritization of HTS Hits

ChemMedChem, 2006-11, Vol.1 (11), p.1229-1236

2006

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A useful application of benzyl trichloroacetimidate for the benzylation of alcohols

Tetrahedron, 1993, Vol.49 (8), p.1619-1624

1993

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Chromanol derivatives—A novel class of CETP inhibitors

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.488-491

2011

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Prediction of a potentially effective dose in humans for BAY 60–5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically‐based pharmacokinetic modelling

British journal of clinical pharmacology, 2012-02, Vol.73 (2), p.219-231

2012

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Fluorine-Substitution in Cholesteryl Ester Transfer Protein Inhibitors (CETPInhibitors) – Biology, Chemistry, SAR, and Properties

Chimia, 2004-03, Vol.58 (3), p.123

2004

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Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60–5521, a potent inhibitor of cholesteryl ester transfer protein

British journal of clinical pharmacology, 2012-02, Vol.73 (2), p.210-218

2012

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Differentiation of arginine vasopressin antagonistic effects by selective V2 versus dual V2/V1a receptor blockade in a preclinical heart failure model

American journal of therapeutics, 2011-01, Vol.18 (1), p.31-37

2011

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Stable Polymer-Bound Iodine Azide

Angewandte Chemie (International ed.), 1999-09, Vol.38 (17), p.2594-2596

1999

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Dibenzodioxocinones—A new class of CETP inhibitors

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3611-3614

2005

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Novel heterocyclic thyromimetics. Part 2

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3992-3996

2007

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Novel heterocyclic thyromimetics

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (7), p.1835-1840

2005

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Stabiles festphasengebundenes Iodazid

Angewandte Chemie, 1999-09, Vol.111 (17), p.2720-2722

1999

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Stereoselektive Mukaiyama-Michael/Michael/Aldol-Dominocyclisierung als Schlüsselschritt der Synthese pentasubstituierter Arene - ein effizienter Zugang zu hochwirksamen Inhibitoren des Cholesterinester-Transferproteins (CETP)

Angewandte Chemie, 1999-11, Vol.111 (22), p.3574-3576

1999

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Stabiles festphasengebundenes Iodazid

Angewandte Chemie, 1999-09, Vol.111 (17), p.2720-2722

1999

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Stereoselektive Mukaiyama‐Michael/Michael/Aldol‐Dominocyclisierung als Schlüsselschritt der Synthese pentasubstituierter Arene – ein effizienter Zugang zu hochwirksamen Inhibitoren des Cholesterinester‐Transferproteins (CETP)

Angewandte Chemie, 1999-11, Vol.111 (22), p.3574-3576

1999

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Small molecules and their impact in drug discovery: A perspective on the occasion of the 125th anniversary of the Bayer Chemical Research Laboratory

Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease

Cardiac output improvement by pecavaptan: a novel dual‐acting vasopressin V1a/V2 receptor antagonist in experimental heart failure

Pharmacological Inhibition of Vanin 1 Is Not Protective in Models of Acute and Chronic Kidney Disease: PO2372

Stereoselective Mukaiyama-Michael/Michael/Aldol Domino Cyclization as the Key Step in the Synthesis of Pentasubstituted Arenes: An Efficient Access to Highly Active Inhibitors of Cholesteryl Ester Transfer Protein (CETP)

Vascular Protection and Decongestion Without Renin-Angiotensin-Aldosterone System Stimulation Mediated by a Novel Dual-Acting Vasopressin V1a/V2 Receptor Antagonist

Synthesis of Optically Active 4-Substituted 2-Aminobutyrolactones and Homoserines by Combined Aldol/Photocyclization Reactions of Chromium Aminocarbene Complexes

Cholesteryl ester transfer protein and its inhibition

Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

Novel tetrahydrochinoline derived CETP inhibitors

In Silico ADMET Traffic Lights as a Tool for the Prioritization of HTS Hits

A useful application of benzyl trichloroacetimidate for the benzylation of alcohols

Chromanol derivatives—A novel class of CETP inhibitors

Prediction of a potentially effective dose in humans for BAY 60–5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically‐based pharmacokinetic modelling

Fluorine-Substitution in Cholesteryl Ester Transfer Protein Inhibitors (CETPInhibitors) – Biology, Chemistry, SAR, and Properties

Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60–5521, a potent inhibitor of cholesteryl ester transfer protein

Differentiation of arginine vasopressin antagonistic effects by selective V2 versus dual V2/V1a receptor blockade in a preclinical heart failure model

Stable Polymer-Bound Iodine Azide

Dibenzodioxocinones—A new class of CETP inhibitors

Novel heterocyclic thyromimetics. Part 2

Novel heterocyclic thyromimetics

Stabiles festphasengebundenes Iodazid

Stereoselektive Mukaiyama-Michael/Michael/Aldol-Dominocyclisierung als Schlüsselschritt der Synthese pentasubstituierter Arene - ein effizienter Zugang zu hochwirksamen Inhibitoren des Cholesterinester-Transferproteins (CETP)

Stabiles festphasengebundenes Iodazid

Stereoselektive Mukaiyama‐Michael/Michael/Aldol‐Dominocyclisierung als Schlüsselschritt der Synthese pentasubstituierter Arene – ein effizienter Zugang zu hochwirksamen Inhibitoren des Cholesterinester‐Transferproteins (CETP)

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