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The biology of p38 kinase: a central role in inflammation

Current topics in medicinal chemistry, 2005-09, Vol.5 (10), p.921

Schieven, Gary L

2005

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Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (15), p.2587-2590

2003

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5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6261-6270

2005

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The Discovery of Orally Active Triaminotriazine Aniline Amides as Inhibitors of p38 MAP Kinase

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6283-6291

2004

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Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (13), p.2145-2149

2003

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Inhibition of Tyrosine Phosphorylation Prevents T-Cell Receptor-Mediated Signal Transduction

Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (19), p.7722-7726

1990

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Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF- Kappa B

The Journal of biological chemistry, 1997-04, Vol.272 (17), p.11541-11549

1997

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Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck)

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4007-4010

2003

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Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation

Biochemistry (Easton), 1997-12, Vol.36 (50), p.15975-15982

1997

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Phosphorylation of the Linker for Activation of T-Cells by Itk Promotes Recruitment of Vav

Biochemistry (Easton), 2002-08, Vol.41 (34), p.10732-10740

2002

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Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.24442-24448

1993

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Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor

Biochemical journal, 1995-10, Vol.311 ( Pt 2) (2), p.471-478

1995

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p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals

The Journal of biological chemistry, 1993-08, Vol.268 (22), p.16688-16692

1993

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Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (24), p.6061-6066

2004

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Hypochlorous Acid Activates Tyrosine Phosphorylation Signal Pathways Leading to Calcium Signaling and TNF α Production

Antioxidants & redox signaling, 2002-06, Vol.4 (3), p.501-507

2002

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Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets

FEBS letters, 1994-10, Vol.353 (2), p.212-216

1994

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Impact of Oxidative Stress on Signal Transduction Control by Phosphotyrosine Phosphatases

Environmental health perspectives, 1998-10, Vol.106, p.1179

1998

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Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck)

Bioorganic & medicinal chemistry letters, 2002-05, Vol.12 (10), p.1361-1364

2002

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Cloning and Expression of the Tumor-Associated Antigen L6

Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (8), p.3503-3507

1992

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Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction

The Journal of immunology (1950), 1994-12, Vol.153 (11), p.4880

1994

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Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20

The Journal of biological chemistry, 1995-09, Vol.270 (38), p.22632-22638

1995

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Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny

The Journal of biological chemistry, 1991-09, Vol.266 (26), p.17478-17485

1991

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The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release

The Journal of immunology (1950), 1991-01, Vol.146 (2), p.715

1991

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Synthesis and SAR of novel imidazoquinoxaline-Based Lck inhibitors: improvement of cell potency

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3153-3156

2002

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The biology of p38 kinase: a central role in inflammation

Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors

5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase

The Discovery of Orally Active Triaminotriazine Aniline Amides as Inhibitors of p38 MAP Kinase

Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117

Inhibition of Tyrosine Phosphorylation Prevents T-Cell Receptor-Mediated Signal Transduction

Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF- Kappa B

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck)

Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation

Phosphorylation of the Linker for Activation of T-Cells by Itk Promotes Recruitment of Vav

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor

p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals

Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors

Hypochlorous Acid Activates Tyrosine Phosphorylation Signal Pathways Leading to Calcium Signaling and TNF α Production

Collagen stimulates tyrosine phosphorylation of phospholipase C-gamma 2 but not phospholipase C-gamma 1 in human platelets

Impact of Oxidative Stress on Signal Transduction Control by Phosphotyrosine Phosphatases

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck)

Cloning and Expression of the Tumor-Associated Antigen L6

Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction

Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny

The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release

Synthesis and SAR of novel imidazoquinoxaline-Based Lck inhibitors: improvement of cell potency

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