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Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

Journal of Virology, 2010-08, Vol.84 (15), p.7625-7633

2010

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Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Journal of molecular biology, 2004-01, Vol.335 (2), p.547-554

2004

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Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

Protein science, 1998-04, Vol.7 (4), p.837-847

1998

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The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3386-3391

2008

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Only a Small Fraction of Purified Hepatitis C RNA-Dependent RNA Polymerase Is Catalytically Competent: Implications for Viral Replication and in Vitro Assays

Biochemistry (Easton), 2000-07, Vol.39 (28), p.8243-8249

2000

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Hinnuliquinone, a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease

Biochemical and biophysical research communications, 2004-11, Vol.324 (1), p.108-113

2004

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Development of thioquinazolinones, allosteric Chk1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1240-1244

2009

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Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6117-6119

2004

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Human Immunodeficiency Virus Type 1 Protease Inhibitors: Evaluation of Resistance Engendered by Amino Acid Substitutions in the Enzyme's Substrate Binding Site

Biochemistry (Easton), 1994-03, Vol.33 (8), p.2004-2010

1994

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Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Journal of molecular biology, 2010-11, Vol.335 ((2) ; 01, 2004)

2010

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X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform

Journal of molecular biology, 2000-02, Vol.296 (2), p.521-533

2000

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Hinnuliquinone, a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease

Biochemical and biophysical research communications, 2004-11, Vol.324 (1), p.108-113

2004

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Hinnuliquinone, a C 2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease

Biochemical and biophysical research communications, 2004-11, Vol.324 (1), p.108-113

2004

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Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5907-5912

2006

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A general procedure for the purification of human β-secretase expressed in Escherichia coli

Protein expression and purification, 2004-04, Vol.34 (2), p.190-196

2004

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5-Chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase

Journal of medicinal chemistry, 1993-04, Vol.36 (9), p.1291-1294

1993

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Chemical modification and cross-linking of neurophysin tyrosine-49

Biochemistry (Easton), 1987-02, Vol.26 (4), p.995-1003

1987

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Substrate requirements of human rhinovirus 3C protease for peptide cleavage in vitro

The Journal of biological chemistry, 1990-06, Vol.265 (16), p.9062-9065

1990

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Sequence-Specific Interaction of Tat Protein and Tat Peptides with the Transactivation-Responsive Sequence Element of Human Immunodeficiency Virus Type 1 in vitro

Proceedings of the National Academy of Sciences - PNAS, 1990-11, Vol.87 (22), p.8985-8989

1990

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Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors

The Journal of biological chemistry, 1992-09, Vol.267 (25), p.17526-17530

1992

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[1] Purification of viral polymerases: General considerations

Methods in Enzymology, 1996, Vol.275, p.3-16

1996

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Peptide substrate cleavage specificity of the human cytomegalovirus protease

The Journal of biological chemistry, 1994-05, Vol.269 (20), p.14337-14340

1994

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Effects of peptide-binding on the proton n.m.r. spectrum of bovine neurophysin-I

International Journal of Peptide and Protein Research, 1983-02, Vol.21 (2), p.182-189

1983

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An Uniquely Purified HCV NS3 Protease and NS4A21–34 Peptide Form a Highly Active Serine Protease Complex in Peptide Hydrolysis

Protein expression and purification, 1999-08, Vol.16 (3), p.440-447

1999

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Human Immunodeficiency Virus 1 (HIV-1)-Specific Reverse Transcriptase (RT) Inhibitors may Suppress the Replication of Specific Drug-Resistant (E138K)RT HIV-1 Mutants or Select for Highly Resistant (Y181C → C181I)RT HIV-1 Mutants

Proceedings of the National Academy of Sciences - PNAS, 1994-07, Vol.91 (14), p.6599-6603

1994

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Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors

Only a Small Fraction of Purified Hepatitis C RNA-Dependent RNA Polymerase Is Catalytically Competent: Implications for Viral Replication and in Vitro Assays

Hinnuliquinone, a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors

Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases

Human Immunodeficiency Virus Type 1 Protease Inhibitors: Evaluation of Resistance Engendered by Amino Acid Substitutions in the Enzyme's Substrate Binding Site

Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform

Hinnuliquinone, a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease

Hinnuliquinone, a C 2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors

A general procedure for the purification of human β-secretase expressed in Escherichia coli

5-Chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase

Chemical modification and cross-linking of neurophysin tyrosine-49

Substrate requirements of human rhinovirus 3C protease for peptide cleavage in vitro

Sequence-Specific Interaction of Tat Protein and Tat Peptides with the Transactivation-Responsive Sequence Element of Human Immunodeficiency Virus Type 1 in vitro

Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors

[1] Purification of viral polymerases: General considerations

Peptide substrate cleavage specificity of the human cytomegalovirus protease

Effects of peptide-binding on the proton n.m.r. spectrum of bovine neurophysin-I

An Uniquely Purified HCV NS3 Protease and NS4A21–34 Peptide Form a Highly Active Serine Protease Complex in Peptide Hydrolysis

Human Immunodeficiency Virus 1 (HIV-1)-Specific Reverse Transcriptase (RT) Inhibitors may Suppress the Replication of Specific Drug-Resistant (E138K)RT HIV-1 Mutants or Select for Highly Resistant (Y181C → C181I)RT HIV-1 Mutants

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