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Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability

Neoplasia (New York, N.Y.), 2019-04, Vol.21 (4), p.363-375

2019

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PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells

Nature communications, 2018-03, Vol.9 (1), p.1106-17, Article 1106

2018

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Sequential Targeting of PLK1 and PARP1 Reverses the Resistance to PARP Inhibitors and Enhances Platin-Based Chemotherapy in BRCA-Deficient High-Grade Serous Ovarian Cancer with KRAS Amplification

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10892

2022

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Cdk1/Cyclin B1 Controls Fas-Mediated Apoptosis by Regulating Caspase-8 Activity

Molecular and Cellular Biology, 2010-12, Vol.30 (24), p.5726-5740

2010

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The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

Cancers, 2021-07, Vol.13 (15), p.3658

2021

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Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8

Cell research, 2016-08, Vol.26 (8), p.914-934

2016

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Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo

The American journal of pathology, 2011-10, Vol.179 (4), p.2091-2099

2011

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Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 Inhibitors

Cancers, 2023-12, Vol.16 (1), p.107

2023

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Synthetic lethality in CCNE1 -amplified high grade serous ovarian cancer through combined inhibition of Polo-like kinase 1 and microtubule dynamics

Oncotarget, 2018-05, Vol.9 (40), p.25842-25859

2018

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The Prognostic Relevance of the Proliferation Markers Ki-67 and Plk1 in Early-Stage Ovarian Cancer Patients With Serous, Low-Grade Carcinoma Based on mRNA and Protein Expression

Frontiers in oncology, 2020-10, Vol.10, p.558932-558932

2020

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Prognostic Impact of Caspase-8, CDK9 and Phospho-CDK9 (Thr 186) Expression in Patients with Uterine Cervical Cancer Treated with Definitive Chemoradiation and Brachytherapy

Cancers, 2022-11, Vol.14 (22), p.5500

2022

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Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

Oncotarget, 2011-12, Vol.2 (12), p.935-947

2011

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The role of PLK1 in cancer exhibiting chromosomal instability

Molecular & cellular oncology, 2018-11, Vol.5 (6), p.e1485539-e1485539

2018

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Rescue of p53 functions by in vitro‐transcribed mRNA impedes the growth of high‐grade serous ovarian cancer

Cancer communications (London, England), 2024-01, Vol.44 (1), p.101-126

2024

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p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors

Cell cycle (Georgetown, Tex.), 2012-02, Vol.11 (3), p.543-553

2012

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Functional and Spatial Regulation of Mitotic Centromere- Associated Kinesin by Cyclin-Dependent Kinase 1

Molecular and Cellular Biology, 2010-06, Vol.30 (11), p.2594-2607

2010

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The regulation of RNA Polymerase II mediated transcription by Caspase-8 in ovarian cancer

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.e18082-e18082

2020

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Boosting the apoptotic response of high-grade serous ovarian cancers with CCNE1-amplification to paclitaxel by targeting APC/C and the pro-survival protein MCL-1

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.e18065-e18065

2020

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Correction: A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1

Oncogene, 2023-08, Vol.42 (34), p.2590-2590

2023

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The Role of DAPK1 in the Cell Cycle Regulation of Cervical Cancer Cells and in Response to Topotecan

Journal of Cancer, 2022, Vol.13 (3), p.728-743

2022

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A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1

Oncogene, 2022-01, Vol.41 (3), p.372-386

2022

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Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8142-8160

2021

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Correction: The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer

Cellular and molecular life sciences : CMLS, 2023-03, Vol.80 (3), p.64-64, Article 64

2023

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Boosting the apoptotic response of high‐grade serous ovarian cancers with CCNE1 amplification to paclitaxel in vitro by targeting APC/C and the pro‐survival protein MCL‐1

International journal of cancer, 2020-02, Vol.146 (4), p.1086-1098

2020

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The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer

Cellular and molecular life sciences : CMLS, 2022-12, Vol.79 (12), p.597-597, Article 597

2022

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Science & Technology
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Life Sciences & Biomedicine
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Humans
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Polo-Like Kinase 1
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Protein Serine-Threonine Kinases - Metabolism
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Cell Biology
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Cell Cycle Proteins - Metabolism
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Proto-Oncogene Proteins - Metabolism
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Cell Line, Tumor
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Animals
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Apoptosis
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Kinases
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Biochemistry & Molecular Biology
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Cell Cycle
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Chemotherapy
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Female
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Ovarian Cancer
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Apoptosis - Drug Effects
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Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability

PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells

Sequential Targeting of PLK1 and PARP1 Reverses the Resistance to PARP Inhibitors and Enhances Platin-Based Chemotherapy in BRCA-Deficient High-Grade Serous Ovarian Cancer with KRAS Amplification

Cdk1/Cyclin B1 Controls Fas-Mediated Apoptosis by Regulating Caspase-8 Activity

The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8

Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo

Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 Inhibitors

Synthetic lethality in CCNE1 -amplified high grade serous ovarian cancer through combined inhibition of Polo-like kinase 1 and microtubule dynamics

The Prognostic Relevance of the Proliferation Markers Ki-67 and Plk1 in Early-Stage Ovarian Cancer Patients With Serous, Low-Grade Carcinoma Based on mRNA and Protein Expression

Prognostic Impact of Caspase-8, CDK9 and Phospho-CDK9 (Thr 186) Expression in Patients with Uterine Cervical Cancer Treated with Definitive Chemoradiation and Brachytherapy

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

The role of PLK1 in cancer exhibiting chromosomal instability

Rescue of p53 functions by in vitro‐transcribed mRNA impedes the growth of high‐grade serous ovarian cancer

p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors

Functional and Spatial Regulation of Mitotic Centromere- Associated Kinesin by Cyclin-Dependent Kinase 1

The regulation of RNA Polymerase II mediated transcription by Caspase-8 in ovarian cancer

Boosting the apoptotic response of high-grade serous ovarian cancers with CCNE1-amplification to paclitaxel by targeting APC/C and the pro-survival protein MCL-1

Correction: A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1

The Role of DAPK1 in the Cell Cycle Regulation of Cervical Cancer Cells and in Response to Topotecan

A dimerization-dependent mechanism regulates enzymatic activation and nuclear entry of PLK1

Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors

Correction: The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer

Boosting the apoptotic response of high‐grade serous ovarian cancers with CCNE1 amplification to paclitaxel in vitro by targeting APC/C and the pro‐survival protein MCL‐1

The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancer

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