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Therapeutic targeting of the angiopoietin-TIE pathway

Nature reviews. Drug discovery, 2017-09, Vol.16 (9), p.635-661

2017

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VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

Trends in molecular medicine, 2011-07, Vol.17 (7), p.347-362

2011

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Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

The Journal of clinical investigation, 2016-09, Vol.126 (9), p.3511-3525

2016

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Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Nature communications, 2015-01, Vol.6 (1), p.5962-5962, Article 5962

2015

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The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

The Journal of clinical investigation, 2014-09, Vol.124 (9), p.3975-3986

2014

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Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

The Journal of clinical investigation, 2022-08, Vol.132 (15), p.1-17

2022

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The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

Development (Cambridge), 2014-12, Vol.141 (23), p.4500-4512

2014

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Signaling and Functions of Angiopoietin-1 in Vascular Protection

Circulation research, 2006-04, Vol.98 (8), p.1014-1023

2006

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The possible dual role of Ang-2 in the prognosis of pancreatic cancer

Scientific reports, 2023-10, Vol.13 (1), p.18725-18725, Article 18725

2023

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Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell-Cell Junctions and Lung Metastasis

JNCI : Journal of the National Cancer Institute, 2012-03, Vol.104 (6), p.461-475

2012

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The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction

The Journal of biological chemistry, 2002-12, Vol.277 (49), p.47954-47963

2002

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VEGF-C and aortic cardiomyocytes guide coronary artery stem development

The Journal of clinical investigation, 2014-11, Vol.124 (11), p.4899-4914

2014

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KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies

PLoS pathogens, 2023-01, Vol.19 (1), p.e1010753-e1010753

2023

Volltextzugriff (PDF)

Angiopoietin signaling in the vasculature

Experimental cell research, 2013-05, Vol.319 (9), p.1271-1280

2013

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Critical requirement of VEGF-C in transition to fetal erythropoiesis

Blood, 2016-08, Vol.128 (5), p.710-720

2016

Volltextzugriff (PDF)

Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain

Molecular biology of the cell, 2003-04, Vol.14 (4), p.1448-1459

2003

Volltextzugriff (PDF)

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma

PloS one, 2016-04, Vol.11 (4), p.e0153745-e0153745

2016

Volltextzugriff (PDF)

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

The Journal of clinical investigation, 2014-02, Vol.124 (2), p.824-834

2014

Volltextzugriff (PDF)

Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report

Arteriosclerosis, thrombosis, and vascular biology, 2010-02, Vol.30 (2), p.207

2010

Volltextzugriff (PDF)

Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain

Molecular and Cellular Biology, 2000-05, Vol.20 (10), p.3387-3395

2000

Volltextzugriff (PDF)

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

Clinical science (1979), 2017-01, Vol.131 (1), p.87

2017

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Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1

Molecular and Cellular Biology, 2002-05, Vol.22 (10), p.3316-3326

2002

Volltextzugriff (PDF)

The yin, the yang, and the angiopoietin-1

The Journal of clinical investigation, 2011-06, Vol.121 (6), p.2157-2159

2011

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Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity

Blood, 2010-01, Vol.115 (4), p.906-909

2010

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Therapeutic targeting of the angiopoietin-TIE pathway

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

Signaling and Functions of Angiopoietin-1 in Vascular Protection

The possible dual role of Ang-2 in the prognosis of pancreatic cancer

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell-Cell Junctions and Lung Metastasis

The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction

VEGF-C and aortic cardiomyocytes guide coronary artery stem development

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation

KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies

Angiopoietin signaling in the vasculature

Critical requirement of VEGF-C in transition to fetal erythropoiesis

Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report

Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1

The yin, the yang, and the angiopoietin-1

Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity

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