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Accurate Prediction of the Relative Potencies of Members of a Series of Kinase Inhibitors Using Molecular Docking and MM-GBSA Scoring

Journal of medicinal chemistry, 2006-08, Vol.49 (16), p.4805-4808

2006

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Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.9897-9919

2013

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AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells

Clinical cancer research, 2020-02, Vol.26 (4), p.922-934

2020

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Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas

Blood, 2021-05, Vol.137 (21), p.2947-2957

2021

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Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (4), p.1690-1694

2012

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Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (7), p.1820-1824

2014

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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Clinical cancer research, 2020-12, Vol.26 (24), p.6535-6549

2020

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Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action

Clinical cancer research, 2017-12, Vol.23 (24), p.7608-7620

2017

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Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1‑Phosphate Receptor 1 Antagonists with in Vivo Activity

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.7057-7075

2015

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Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (10), p.2041-2045

2015

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Lead Hopping Using SVM and 3D Pharmacophore Fingerprints

Journal of chemical information and modeling, 2005-07, Vol.45 (4), p.1122-1133

2005

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Equation-of-motion coupled-cluster methods for ionized states with an approximate treatment of triple excitations

The Journal of chemical physics, 2005-04, Vol.122 (15), p.154107-154107

2005

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Structure and Energetics of Isomers of the Interstellar Molecule C5H

Journal of the American Chemical Society, 1999-03, Vol.121 (9), p.1902-1911

1999

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Abstract 2459: Discovery of small molecule TAK1 inhibitors with antiproliferative activity in cell lines derived from hematological malignancies

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.2459-2459

2013

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Abstract 3362: Miniaturized PBPK model improves pharmacodynamic characterization and physiological interpretability for compounds with profound hysteresis in tumor

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3362-3362

2013

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Abstract 2916: Discovery of pyrazolimidazopyridine compounds as potent in vitro and in vivo anaplastic lymphoma kinase inhibitors

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.2916-2916

2012

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Computational Evidence for a Metastable Polar Isomer of Beryllium Borohydride

Journal of the American Chemical Society, 1997-08, Vol.119 (31), p.7390-7391

1997

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Abstract 2461: Design and synthesis of AZD3463, a novel orally bioavailable dual ALK and IGF1R inhibitor, inhibits growth of crizotinib resistance cell lines with multiple mechanisms of acquired resistance

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.2461-2461

2013

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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x L , Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Clinical cancer research, 2020-12, Vol.26 (24), p.6535

2020

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Abstract B100: Structure-based design of AZ7732 a novel in vivo active beta-alanine-derived pan-IAP inhibitor

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B100-B100

2013

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Abstract 3910: Lead optimization of a series of 5-aminopyrazol-imidazopyridine compounds as potent anaplastic lymphoma kinase inhibitors active against clinically relevant ALK mutations

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.3910-3910

2012

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Application of an equation-of-motion coupled cluster method including higher-order corrections to potential energy surfaces of radicals

The Journal of chemical physics, 1999-11, Vol.111 (18), p.8275-8285

1999

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Structure and Energetics of Isomers of the Interstellar Molecule C 5 H

Journal of the American Chemical Society, 1999-03, Vol.121 (9), p.1902-1911

1999

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Lead Hopping Using SVM and 3D Pharmacophore Fingerprints

ChemInform, 2005-09, Vol.36 (39), p.no-no

2005

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Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

Science translational medicine, 2012-02, Vol.4 (120), p.120ra17

2012

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Accurate Prediction of the Relative Potencies of Members of a Series of Kinase Inhibitors Using Molecular Docking and MM-GBSA Scoring

Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells

Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas

Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action

Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1‑Phosphate Receptor 1 Antagonists with in Vivo Activity

Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists

Lead Hopping Using SVM and 3D Pharmacophore Fingerprints

Equation-of-motion coupled-cluster methods for ionized states with an approximate treatment of triple excitations

Structure and Energetics of Isomers of the Interstellar Molecule C5H

Abstract 2459: Discovery of small molecule TAK1 inhibitors with antiproliferative activity in cell lines derived from hematological malignancies

Abstract 3362: Miniaturized PBPK model improves pharmacodynamic characterization and physiological interpretability for compounds with profound hysteresis in tumor

Abstract 2916: Discovery of pyrazolimidazopyridine compounds as potent in vitro and in vivo anaplastic lymphoma kinase inhibitors

Computational Evidence for a Metastable Polar Isomer of Beryllium Borohydride

Abstract 2461: Design and synthesis of AZD3463, a novel orally bioavailable dual ALK and IGF1R inhibitor, inhibits growth of crizotinib resistance cell lines with multiple mechanisms of acquired resistance

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x L , Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Abstract B100: Structure-based design of AZ7732 a novel in vivo active beta-alanine-derived pan-IAP inhibitor

Abstract 3910: Lead optimization of a series of 5-aminopyrazol-imidazopyridine compounds as potent anaplastic lymphoma kinase inhibitors active against clinically relevant ALK mutations

Application of an equation-of-motion coupled cluster method including higher-order corrections to potential energy surfaces of radicals

Structure and Energetics of Isomers of the Interstellar Molecule C 5 H

Lead Hopping Using SVM and 3D Pharmacophore Fingerprints

Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

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