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Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

The New England journal of medicine, 2018-05, Vol.378 (18), p.1691-1703

2018

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Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

The New England journal of medicine, 2019-04, Vol.380 (15), p.1408-1420

2019

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A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images

European journal of nuclear medicine and molecular imaging, 2021-07, Vol.48 (7), p.2183-2199

2021

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Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (37), p.15950-15955

2009

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Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles

Molecular imaging and biology, 2020-02, Vol.22 (1), p.173-180

2020

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A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240

EJNMMI research, 2021-05, Vol.11 (1), p.49-13, Article 49

2021

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Evaluation of 18F-flutemetamol amyloid PET image analysis parameters on the effect of verubecestat on brain amlyoid load in Alzheimer’s disease

Molecular imaging and biology, 2022-12, Vol.24 (6), p.862-873

2022

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Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors

Current topics in medicinal chemistry, 2010-02, Vol.10 (2), p.170-186

2010

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.199-206

2005

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N-Desmethylclozapine, an Allosteric Agonist at Muscarinic 1 Receptor, Potentiates N-Methyl-D-Aspartate Receptor Activity

Proceedings of the National Academy of Sciences - PNAS, 2003-11, Vol.100 (23), p.13674-13679

2003

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Glycine transporter 1 inhibitors and modulation of NMDA receptor-mediated excitatory neurotransmission

Current drug targets, 2007-05, Vol.8 (5), p.643-649

2007

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Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia

Current topics in medicinal chemistry, 2006-04, Vol.6 (8), p.771-785

2006

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A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Molecular pharmacology, 2003-09, Vol.64 (3), p.731-740

2003

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Non-invasive bioluminescence imaging of β-cell function in obese-hyperglycemic [ob/ob] mice

PloS one, 2014-09, Vol.9 (9), p.e106693-e106693

2014

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

The Journal of pharmacology and experimental therapeutics, 2004-05, Vol.309 (2), p.568-577

2004

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Ex Vivo Imaging of Pancreatic Beta Cells using a Radiolabeled GLP-1 Receptor Agonist

Molecular imaging and biology, 2012-02, Vol.14 (1), p.79-87

2012

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Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT)

Molecular imaging and biology, 2010-10, Vol.12 (5), p.488-499

2010

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The synthesis and preclinical evaluation in rhesus monkey of [18F]MK-6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

Synapse (New York, N.Y.), 2011-04, Vol.65 (4), p.261-270

2011

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A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo

American journal of physiology. Renal physiology, 2012-08, Vol.303 (4), p.F593-F603

2012

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A Quantitative Volumetric Micro-Computed Tomography Method to Analyze Lung Tumors in Genetically Engineered Mouse Models

Neoplasia (New York, N.Y.), 2009-01, Vol.11 (1), p.39-47

2009

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The therapeutic potential of glycine transporter-1 inhibitors

Expert opinion on investigational drugs, 2004-05, Vol.13 (5), p.515-521

2004

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In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease

Brain (London, England : 1878), 2013-07, Vol.136 (Pt 7), p.2228-2238

2013

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Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease

Journal of cerebral blood flow and metabolism, 2020-11, Vol.40 (11), p.2179-2187

2020

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Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1488-1491

2009

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A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies

Nuclear medicine and biology, 2008-04, Vol.35 (3), p.315-325

2008

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Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [18F]flutemetamol amyloid PET images

Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation

Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles

A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240

Evaluation of 18F-flutemetamol amyloid PET image analysis parameters on the effect of verubecestat on brain amlyoid load in Alzheimer’s disease

Recent progress in the discovery of non-sarcosine based GlyT1 inhibitors

A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

N-Desmethylclozapine, an Allosteric Agonist at Muscarinic 1 Receptor, Potentiates N-Methyl-D-Aspartate Receptor Activity

Glycine transporter 1 inhibitors and modulation of NMDA receptor-mediated excitatory neurotransmission

Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia

A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Non-invasive bioluminescence imaging of β-cell function in obese-hyperglycemic [ob/ob] mice

A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain

Ex Vivo Imaging of Pancreatic Beta Cells using a Radiolabeled GLP-1 Receptor Agonist

Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT)

The synthesis and preclinical evaluation in rhesus monkey of [18F]MK-6577 and [11C]CMPyPB glycine transporter 1 positron emission tomography radiotracers

A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo

A Quantitative Volumetric Micro-Computed Tomography Method to Analyze Lung Tumors in Genetically Engineered Mouse Models

The therapeutic potential of glycine transporter-1 inhibitors

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease

Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease

Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors

A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies

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