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Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)

Seminars in oncology, 1999-08, Vol.26 (4), p.60-70

1999

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Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms

Oncogene, 2009-03, Vol.28 (10), p.1309-1319

2009

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Untangling the ErbB signalling network

Nature reviews. Molecular cell biology, 2001-02, Vol.2 (2), p.127-137

2001

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Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

The Journal of biological chemistry, 1994-05, Vol.269 (20), p.14661-14665

1994

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Overexpression of HER2/neu in solid tumours: an immunohistochemical survey

Histopathology, 2001-02, Vol.38 (2), p.96-104

2001

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Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Cancer cell, 2004-04, Vol.5 (4), p.317-328

2004

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CD20 : A gene in search of a function

Seminars in oncology, 2000-12, Vol.27 (6), p.17-24

2000

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The erbB3 gene product is a receptor for heregulin

The Journal of biological chemistry, 1994-05, Vol.269 (19), p.14303-14306

1994

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Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab

Cancer Immunology, Immunotherapy, 2006-06, Vol.55 (6), p.717-727

2006

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Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells

Oncogene, 1999-10, Vol.18 (44), p.6050-6062

1999

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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

Cancer cell, 2002-08, Vol.2 (2), p.127-137

2002

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Identification of heregulin, a specific activator of p185erbB2

Science (American Association for the Advancement of Science), 1992-05, Vol.256 (5060), p.1205-1210

1992

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γ-Heregulin : a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175

Oncogene, 1997-09, Vol.15 (12), p.1385-1394

1997

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Growth regulation of human breast and ovarian tumor cells by heregulin : Evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness

Cancer research (Chicago, Ill.), 1996-03, Vol.56 (6), p.1457-1465

1996

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Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin

The Journal of biological chemistry, 1994-02, Vol.269 (8), p.6241-6245

1994

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Identification of Gas6 as a growth factor for human Schwann cells

The Journal of neuroscience, 1996-03, Vol.16 (6), p.2012-2019

1996

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Binding specificities and affinities of egf domains for ErbB receptors

FEBS letters, 1999-03, Vol.447 (2), p.227-231

1999

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Neuregulin-3 (NRG3): A Novel Neural Tissue-Enriched Protein that Binds and Activates ErbB4

Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (18), p.9562-9567

1997

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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

Cancer cell, 2009-05, Vol.15 (5), p.429-440

2009

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Targeting cyclooxygenase 2 and her-2/neu pathways inhibits colorectal carcinoma growth

Gastroenterology (New York, N.Y. 1943), 2001-06, Vol.120 (7), p.1713-1719

2001

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A potential role for activated HER-2 in prostate cancer

Seminars in oncology, 2000-12, Vol.27 (6), p.76-83

2000

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A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and Erbb4

Cancer research (Chicago, Ill.), 2001-06, Vol.61 (11), p.4467-4473

2001

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Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells

Oncogene, 1996-06, Vol.12 (11), p.2473-2477

1996

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Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor

The Journal of biological chemistry, 2002-11, Vol.277 (48), p.46265-46272

2002

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The influence of heregulins on human Schwann cell proliferation

The Journal of neuroscience, 1995-02, Vol.15 (2), p.1329-1340

1995

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Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)

Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms

Untangling the ErbB signalling network

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin

Overexpression of HER2/neu in solid tumours: an immunohistochemical survey

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

CD20 : A gene in search of a function

The erbB3 gene product is a receptor for heregulin

Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab

Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

Identification of heregulin, a specific activator of p185erbB2

γ-Heregulin : a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175

Growth regulation of human breast and ovarian tumor cells by heregulin : Evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness

Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin

Identification of Gas6 as a growth factor for human Schwann cells

Binding specificities and affinities of egf domains for ErbB receptors

Neuregulin-3 (NRG3): A Novel Neural Tissue-Enriched Protein that Binds and Activates ErbB4

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

Targeting cyclooxygenase 2 and her-2/neu pathways inhibits colorectal carcinoma growth

A potential role for activated HER-2 in prostate cancer

A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and Erbb4

Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells

Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor

The influence of heregulins on human Schwann cell proliferation

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