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2-Oxoglutarate-Dependent Oxygenases

Annual review of biochemistry, 2018-06, Vol.87 (1), p.585-620

2018

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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

Trends in biochemical sciences (Amsterdam. Regular ed.), 2011, Vol.36 (1), p.7-18

2011

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Expanding chemical biology of 2-oxoglutarate oxygenases

Nature chemical biology, 2008-03, Vol.4 (3), p.152-156

2008

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Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

Nature communications, 2016-06, Vol.7 (1), p.11974-11974, Article 11974

2016

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Mechanisms of human histone and nucleic acid demethylases

Current opinion in chemical biology, 2012-12, Vol.16 (5-6), p.525-534

2012

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Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Nature (London), 2022-11, Vol.611 (7937), p.721-726

2022

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Recent Progress in Histone Demethylase Inhibitors

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1308-1329

2016

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Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model

Scientific reports, 2020-01, Vol.10 (1), p.1597, Article 1597

2020

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Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Chemical science (Cambridge), 2017, Vol.8 (11), p.7651-7668

2017

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Pharmacological targeting of the HIF hydroxylases – A new field in medicine development

Molecular aspects of medicine, 2016-02, Vol.47-48, p.54-75

2016

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Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Nature communications, 2016-08, Vol.7 (1), p.12406-12406, Article 12406

2016

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The oxygenase Jmjd6--a case study in conflicting assignments

Biochemical journal, 2015-06, Vol.468 (2), p.191-202

2015

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Structure–function relationships of human JmjC oxygenases—demethylases versus hydroxylases

Current opinion in structural biology, 2016-12, Vol.41, p.62-72

2016

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Elimination of Rhodnius prolixus in Central America

Parasites & vectors, 2012-02, Vol.5 (1), p.45-45, Article 45

2012

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MeDBA: the Metalloenzyme Data Bank and Analysis platform

Nucleic acids research, 2023-01, Vol.51 (D1), p.D593-D602

2023

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Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

Current opinion in structural biology, 2012-12, Vol.22 (6), p.691-700

2012

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Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Nucleic acids research, 2022-02, Vol.50 (3), p.1484-1500

2022

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

EMBO reports, 2011-05, Vol.12 (5), p.463-469

2011

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Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Nature communications, 2017-04, Vol.8 (1), p.14773-10, Article 14773

2017

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Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

The Journal of biological chemistry, 2016-09, Vol.291 (39), p.20661-20673

2016

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Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

Journal of the American Chemical Society, 2014-07, Vol.136 (26), p.9308-9319

2014

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Inhibition of 2-oxoglutarate dependent oxygenases

Chemical Society reviews, 2011-01, Vol.40 (8), p.4364-4397

2011

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DNA Modification under Mild Conditions by Suzuki-Miyaura Cross-Coupling for the Generation of Functional Probes

Angewandte Chemie (International ed.), 2013-09, Vol.52 (40), p.10553-10558

International ed. in English, 2013

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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Nature communications, 2016-08, Vol.7 (1), p.12673-12673, Article 12673

2016

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Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation

ACS catalysis, 2020-01, Vol.10 (2), p.1195-1209

2020

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2-Oxoglutarate-Dependent Oxygenases

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

Expanding chemical biology of 2-oxoglutarate oxygenases

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

Mechanisms of human histone and nucleic acid demethylases

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Recent Progress in Histone Demethylase Inhibitors

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Pharmacological targeting of the HIF hydroxylases – A new field in medicine development

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

The oxygenase Jmjd6--a case study in conflicting assignments

Structure–function relationships of human JmjC oxygenases—demethylases versus hydroxylases

Elimination of Rhodnius prolixus in Central America

MeDBA: the Metalloenzyme Data Bank and Analysis platform

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

Inhibition of 2-oxoglutarate dependent oxygenases

DNA Modification under Mild Conditions by Suzuki-Miyaura Cross-Coupling for the Generation of Functional Probes

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation

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