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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Leukemia, 2012-11, Vol.26 (11), p.2326-2335

2012

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Apremilast, a cAMP phosphodiesterase‐4 inhibitor, demonstrates anti‐inflammatory activity in vitro and in a model of psoriasis

British journal of pharmacology, 2010-02, Vol.159 (4), p.842-855

2010

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Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

Cellular signalling, 2014-09, Vol.26 (9), p.2016-2029

2014

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THU0245 Phosphodiesterase 4 Expression in Rheumatoid Arthritis Synovium and Effects of Apremilast on Synovial Fibroblasts

Annals of the rheumatic diseases, 2013-06, Vol.72 (Suppl 3), p.A248-A248

2013

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6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase Inhibitor

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4196-4198

1998

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Potent inhibitors of the MAP kinase p38

Bioorganic & medicinal chemistry letters, 1998-12, Vol.8 (23), p.3335-3340

1998

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RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

The Journal of pharmacology and experimental therapeutics, 1999-11, Vol.291 (2), p.680

1999

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Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

The Journal of experimental medicine, 1998-06, Vol.187 (12), p.2073-2079

1998

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p38 alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells

The Journal of immunology (1950), 1999-06, Vol.162 (12), p.7110-7119

1999

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Mechanisms Underlying the Clinical Effects of Apremilast for Psoriasis

Journal of drugs in dermatology, 2018-08, Vol.17 (8), p.835

2018

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The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results from a Phase III, Randomized, Placebo-Controlled Trial (PALACE 1)

Journal of Immunology Research, 2015-01, Vol.2015 (2015), p.1-10

2015

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T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes

The Journal of immunology (1950), 1999-01, Vol.162 (2), p.659-668

1999

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Evidence for dimers of MHC class II molecules in B lymphocytes and their role in low affinity T cell responses

Immunity (Cambridge, Mass.), 1994-11, Vol.1 (8), p.699-707

1994

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SAT0028 Aiolos overexpression in systemic lupus erythematosus b-cell subtypes and baff induced memory b-cell differentiation are reduced by cc-220 modulation of cereblon activity

Annals of the rheumatic diseases, 2017-06, Vol.76 (Suppl 2), p.778

2017

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SAT0035 Inhibition of protein kinase c theta by the selective inhibitor cc-90005 induces t cell anergy

Annals of the rheumatic diseases, 2017-06, Vol.76 (Suppl 2), p.780

2017

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HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes

The Journal of immunology (1950), 1996-12, Vol.157 (12), p.5487-5495

1996

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The Assembly and Stability of MHC Class II-({alpha}{beta})2 Superdimers

The Journal of immunology (1950), 1998-09, Vol.161 (5), p.2307-2316

1998

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Kinetics of small molecule inhibitor binding to p38 kinase

European journal of biochemistry, 2001-11, Vol.268 (22), p.5747-5754

2001

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Heat shock enhances antigen processing and accelerates the formation of compact class II alpha beta dimers

The Journal of immunology (1950), 1994-02, Vol.152 (4), p.1546-1556

1994

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The structure of MHC class II: a role for dimer of dimers

Seminars in immunology, 1995-12, Vol.7 (6), p.389-398

1995

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SAT0255 A randomized, placebo-controlled, double-blind, ascending-dose, safety study of CC-220 in subjects with systemic lupus erythematosus

Annals of the rheumatic diseases, 2017-06, Vol.76 (Suppl 2), p.870

2017

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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Leukemia, 2012-11, Vol.26 (11), p.2445-2445

2012

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Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1222-1232

2003

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Erratum: Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Leukemia, 2012-11, Vol.26 (11), p.2445-2445

2012

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The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity

Cancer research (Chicago, Ill.), 2006-01, Vol.66 (2), p.951-959

2006

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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Apremilast, a cAMP phosphodiesterase‐4 inhibitor, demonstrates anti‐inflammatory activity in vitro and in a model of psoriasis

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

THU0245 Phosphodiesterase 4 Expression in Rheumatoid Arthritis Synovium and Effects of Apremilast on Synovial Fibroblasts

6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2,3-b]pyridine (RWJ 68354): A Potent and Selective p38 Kinase Inhibitor

Potent inhibitors of the MAP kinase p38

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

p38 alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells

Mechanisms Underlying the Clinical Effects of Apremilast for Psoriasis

The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results from a Phase III, Randomized, Placebo-Controlled Trial (PALACE 1)

T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes

Evidence for dimers of MHC class II molecules in B lymphocytes and their role in low affinity T cell responses

SAT0028 Aiolos overexpression in systemic lupus erythematosus b-cell subtypes and baff induced memory b-cell differentiation are reduced by cc-220 modulation of cereblon activity

SAT0035 Inhibition of protein kinase c theta by the selective inhibitor cc-90005 induces t cell anergy

HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes

The Assembly and Stability of MHC Class II-({alpha}{beta})2 Superdimers

Kinetics of small molecule inhibitor binding to p38 kinase

Heat shock enhances antigen processing and accelerates the formation of compact class II alpha beta dimers

The structure of MHC class II: a role for dimer of dimers

SAT0255 A randomized, placebo-controlled, double-blind, ascending-dose, safety study of CC-220 in subjects with systemic lupus erythematosus

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

Erratum: Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity

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