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RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (49), p.19754-19759

2013

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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Molecular cell, 2019-02, Vol.73 (3), p.621-638.e17

2019

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Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1642-1647

2016

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High-throughput production of human proteins for crystallization: The SGC experience

Journal of structural biology, 2010-10, Vol.172 (1), p.3-13

2010

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Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex

Nucleic acids research, 2019-02, Vol.47 (3), p.1225

2019

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Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Structure (London), 2013-06, Vol.21 (6), p.986-996

2013

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Redox Regulation of Cdc25C

The Journal of biological chemistry, 2002-06, Vol.277 (23), p.20535-20540

2002

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Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Nucleic acids research, 2015-05, Vol.43 (10), p.5221

2015

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Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.6998-7011

2017

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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Nature, 2007-07, Vol.448 (7149), p.87-91

2007

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Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Scientific reports, 2017-08, Vol.7 (1), p.7501-12, Article 7501

2017

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Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4

Journal of molecular biology, 2010-08, Vol.401 (3), p.389-402

2010

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Assessing histone demethylase inhibitors in cells: lessons learned

Epigenetics & chromatin, 2017-03, Vol.10 (1), Article 9

2017

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Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

Nature communications, 2014-11, Vol.5 (1), p.5556-5556, Article 5556

2014

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Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

Nucleic acids research, 2017-04, Vol.45 (7), p.4231

2017

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Type II Inhibitors Targeting CDK2

ACS chemical biology, 2015-09, Vol.10 (9), p.2116-2125

2015

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In Vivo Biotinylation of Antigens in E. coli

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1586, p.337

2017

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Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin

Cell reports (Cambridge), 2016-12, Vol.17 (10), p.2724-2737

2016

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8‑Substituted Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1388-1409

2016

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Pilot scale production and isolation of recombinant NAD+- and NADP+-specific formate dehydrogenases

Biotechnology and bioengineering, 1999-07, Vol.64 (2), p.187-193

1999

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Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

Journal of medicinal chemistry, 2017-01, Vol.60 (2), p.668-680

2017

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A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

Chemistry & biology, 2013-01, Vol.20 (1), p.55-62

2013

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Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation

ACS chemical biology, 2017-10, Vol.12 (10), p.2619-2630

2017

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Frapid: achieving full automation of FRAP for chemical probe validation

Biomedical optics express, 2016-02, Vol.7 (2), p.422-441

2016

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RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

High-throughput production of human proteins for crystallization: The SGC experience

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex

Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition

Redox Regulation of Cdc25C

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4

Assessing histone demethylase inhibitors in cells: lessons learned

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5

Type II Inhibitors Targeting CDK2

In Vivo Biotinylation of Antigens in E. coli

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein‑1 by the Use of Virtual Screening and Hydration Analysis

8‑Substituted Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Pilot scale production and isolation of recombinant NAD+- and NADP+-specific formate dehydrogenases

Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies

A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation

Frapid: achieving full automation of FRAP for chemical probe validation

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