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Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA

Bioorganic & medicinal chemistry, 1994-08, Vol.2 (8), p.807-825

1994

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Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA—II. Modification of pyrrolidine ring at P1′ proline

Bioorganic & medicinal chemistry, 1996-08, Vol.4 (8), p.1365-1377

1996

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内部収益率(internal rate of return:IRR)

ファルマシア, 2013, Vol.49(10), pp.970_4-970_4

2013

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日本の医薬品産業の発展に向けて: 創薬ベンチャーを活用した新薬創出

ファルマシア, 2013/10/01, Vol.49(10), pp.965-969

2013

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In Vitro and Ex Vivo Anti-human Immunodeficiency Virus (HIV) Activities of a New Water-Soluble HIV Protease Inhibitor, R-87366, Containing (2S, 3S)-3-Amino-2-hydroxy-4-phenylbutanoic Acid

Biological and Pharmaceutical Bulletin, 1997/02/15, Vol.20(2), pp.175-180

1997

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Synthesis and biological activity of novel α-substituted β-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents

Bioorganic & medicinal chemistry, 2004-05, Vol.12 (9), p.2419-2439

2004

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Net Present Value-Based Analyses of Products in Development by Pharmaceutical and Biotech Firms: NPV-Based Analyses of Biopharmaceutical Products

2018 Portland International Conference on Management of Engineering and Technology (PICMET), 2018, p.1-10

2018

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Studies of HIV-1 protease inhibitors. I: Incorporation of a reduced peptide, simple aminoalcohol, and statine analog at the scissile site of substrate sequences

Chemical & pharmaceutical bulletin, 1993, Vol.41 (8), p.1369-1377

1993

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Studies of HIV-1 protease inhibitors. II: Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences

Chemical & pharmaceutical bulletin, 1993, Vol.41 (8), p.1378-1386

1993

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Studies of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitors. III. Structure-Activity Relationship of HIV-1 Protease Inhibitors Containing Cyclohexylalanylalanine Hydroxyethylene Dipeptide lsostere

Chemical & pharmaceutical bulletin, 1994, Vol.42 (3), p.534-540

1994

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Studies on Peptides. CLII. Hard Acid Deprotecting Procedure for Peptide Synthesis

Chemical and Pharmaceutical Bulletin, 1987/08/25, Vol.35(8), pp.3447-3452

1987

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Design and synthesis of a cocaine-diamide hapten for vaccine development

Tetrahedron letters, 1996-07, Vol.37 (31), p.5479-5482

1996

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The current status and value creation of unlisted Biotech Drug Discovery/Development Firms (Biotech DDFs) in Japan: A holistic approach

Proceedings of PICMET '14 Conference: Portland International Center for Management of Engineering and Technology; Infrastructure and Service Integration, 2014, p.3612-3620

2014

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Asymmetric synthesis of 2-substitued-3-aminocarbonyl propionic acid

Chemical & pharmaceutical bulletin, 1989, Vol.37 (8), p.2200-2203

1989

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Studies on Peptides. CXXXIX. : Solution Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Human Glucose-Dependent Insulinotropic Polypeptide (GIP)

Chemical and Pharmaceutical Bulletin, 1986/06/25, Vol.34(6), pp.2397-2410

1986

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SYNTHESIS OF A 42 RESIDUE PEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF HUMAN GIP

Chemical and Pharmaceutical Bulletin, 1985/08/25, Vol.33(8), pp.3578-3581

1985

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Studies on Peptides. CXXXIII. : Synthesis and Biological Activity of Galanin, a Novel Porcine Intestinal Polypeptide

Chemical and Pharmaceutical Bulletin, 1986/02/25, Vol.34(2), pp.528-539

1986

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A new synthetic route for the γ-lactone precursors of hydroxyethylene dipeptide isosteres

Tetrahedron letters, 1993-09, Vol.34 (37), p.5939-5942

1993

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Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity

Bioorganic & medicinal chemistry letters, 1996-05, Vol.6 (9), p.1055-1060

1996

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Studies on Peptides. CXLI. : Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Porcine GIP (Glucose-Dependent Insulinotropic Polypeptide)

Chemical and Pharmaceutical Bulletin, 1986/08/25, Vol.34(8), pp.3447-3453

1986

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Studies on Peptides. CXXXI. Synthesis of Adrenorphin and Enkephalin Analogs

Chemical and Pharmaceutical Bulletin, 1985/10/25, Vol.33(10), pp.4326-4332

1985

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Studies of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitors. III. Structure-Activity Relationship of HIV-1 Protease Inhibitors Containing Cyclohexylalanylalanine Hydroxyethylene Dipeptide Isostere

Chemical and Pharmaceutical Bulletin, 1994/03/15, Vol.42(3), pp.534-540

1994

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Asymmetric Synthesis of 2-Substituted-3-aminocarbonyl Propionic Acid

Chemical and Pharmaceutical Bulletin, 1989/08/25, Vol.37(8), pp.2200-2203

1989

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Syntheses and biological activities of renin inhibitors containing statine analogues

Chemical & pharmaceutical bulletin, 1990, Vol.38 (1), p.103-109

1990

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Studies of HIV-1 Protease Inhibitors. I.Incorporation of a Reduced Peptide, Simple Aminoalcohol, and Statine Analog at the Scissile Site Substrate Sequences

Chemical and Pharmaceutical Bulletin, 1993/08/15, Vol.41(8), pp.1369-1377

1993

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Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA

Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA—II. Modification of pyrrolidine ring at P1′ proline

内部収益率(internal rate of return:IRR)

日本の医薬品産業の発展に向けて: 創薬ベンチャーを活用した新薬創出

In Vitro and Ex Vivo Anti-human Immunodeficiency Virus (HIV) Activities of a New Water-Soluble HIV Protease Inhibitor, R-87366, Containing (2S, 3S)-3-Amino-2-hydroxy-4-phenylbutanoic Acid

Synthesis and biological activity of novel α-substituted β-phenylpropionic acids having pyridin-2-ylphenyl moiety as antihyperglycemic agents

Net Present Value-Based Analyses of Products in Development by Pharmaceutical and Biotech Firms: NPV-Based Analyses of Biopharmaceutical Products

Studies of HIV-1 protease inhibitors. I: Incorporation of a reduced peptide, simple aminoalcohol, and statine analog at the scissile site of substrate sequences

Studies of HIV-1 protease inhibitors. II: Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences

Studies of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitors. III. Structure-Activity Relationship of HIV-1 Protease Inhibitors Containing Cyclohexylalanylalanine Hydroxyethylene Dipeptide lsostere

Studies on Peptides. CLII. Hard Acid Deprotecting Procedure for Peptide Synthesis

Design and synthesis of a cocaine-diamide hapten for vaccine development

The current status and value creation of unlisted Biotech Drug Discovery/Development Firms (Biotech DDFs) in Japan: A holistic approach

Asymmetric synthesis of 2-substitued-3-aminocarbonyl propionic acid

Studies on Peptides. CXXXIX. : Solution Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Human Glucose-Dependent Insulinotropic Polypeptide (GIP)

SYNTHESIS OF A 42 RESIDUE PEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF HUMAN GIP

Studies on Peptides. CXXXIII. : Synthesis and Biological Activity of Galanin, a Novel Porcine Intestinal Polypeptide

A new synthetic route for the γ-lactone precursors of hydroxyethylene dipeptide isosteres

Synthesis of a nucleoside hapten with a [P(O)-O-N] linkage to elicit catalytic antibodies with phosphodiesterase activity

Studies on Peptides. CXLI. : Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Porcine GIP (Glucose-Dependent Insulinotropic Polypeptide)

Studies on Peptides. CXXXI. Synthesis of Adrenorphin and Enkephalin Analogs

Studies of Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitors. III. Structure-Activity Relationship of HIV-1 Protease Inhibitors Containing Cyclohexylalanylalanine Hydroxyethylene Dipeptide Isostere

Asymmetric Synthesis of 2-Substituted-3-aminocarbonyl Propionic Acid

Syntheses and biological activities of renin inhibitors containing statine analogues

Studies of HIV-1 Protease Inhibitors. I.Incorporation of a Reduced Peptide, Simple Aminoalcohol, and Statine Analog at the Scissile Site Substrate Sequences

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