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Virtual Twins: Understanding the Data Required for Model‐Informed Precision Dosing

Clinical pharmacology and therapeutics, 2020-04, Vol.107 (4), p.742-745

2020

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Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment

Alimentary pharmacology & therapeutics, 2021-08, Vol.54 (4), p.388-401

2021

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Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading

Journal of clinical pharmacology, 2020-10, Vol.60 (S1 Suppl 1), p.S12-S16

2020

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Physiological‐based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20‐years; in‐depth analysis of applications, organizations, and platforms

Biopharmaceutics & drug disposition, 2021-04, Vol.42 (4), p.107-117

2021

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Linking in vitro–in vivo extrapolations with physiologically based modeling to inform drug and formulation development

Biopharmaceutics & drug disposition, 2023-08, Vol.44 (4), p.289-291

2023

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Scientific considerations to move towards biowaiver for biopharmaceutical classification system class III drugs: How modeling and simulation can help

Biopharmaceutics & drug disposition, 2021-04, Vol.42 (4), p.118-127

2021

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Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence

Clinical pharmacology and therapeutics, 2018-02, Vol.103 (2), p.224-232

Rostami‐Hodjegan, Amin

2018

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Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Clinical pharmacology and therapeutics, 2019-09, Vol.106 (3), p.525-543

2019

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In-depth analysis of patterns in selection of different physiologically-based pharmacokinetic modeling tools: Part II - Assessment of model reusability and comparison between open and non-open source-code software

Biopharmaceutics & drug disposition, 2023-08, Vol.44 (4), p.292-300

2023

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Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

Pediatric anesthesia, 2011-03, Vol.21 (3), p.291-301

2011

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Identification and quantification of blood–brain barrier transporters in isolated rat brain microvessels

Journal of neurochemistry, 2018-09, Vol.146 (6), p.670-685

2018

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In‐depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I – Applications and rationale behind the use of open source‐code software

Biopharmaceutics & drug disposition, 2023-06, Vol.44 (3), p.274-285

2023

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Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

British journal of clinical pharmacology, 2015-01, Vol.79 (1), p.48-55

2015

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Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

British journal of clinical pharmacology, 2014-03, Vol.77 (3), p.554-570

2014

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Does “Birth” as an Event Impact Maturation Trajectory of Renal Clearance via Glomerular Filtration? Reexamining Data in Preterm and Full‐Term Neonates by Avoiding the Creatinine Bias

Journal of clinical pharmacology, 2021-02, Vol.61 (2), p.159-171

2021

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A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

Drug metabolism and pharmacokinetics, 2009-01, Vol.24 (1), p.53-75

2009

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Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate

CPT: pharmacometrics and systems pharmacology, 2021-05, Vol.10 (5), p.420-427

2021

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Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults

Biopharmaceutics & drug disposition, 2015-05, Vol.36 (4), p.245-257

2015

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Seeing what is behind the smokescreen: A systematic review of methodological aspects of smoking interaction studies over the last three decades and implications for future clinical trials

Clinical and translational science, 2023-05, Vol.16 (5), p.742-758

2023

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GASP and FASP are Complementary for LC–MS/MS Proteomic Analysis of Drug‐Metabolizing Enzymes and Transporters in Pig Liver

Proteomics (Weinheim), 2018-12, Vol.18 (24), p.e1800200-n/a

2018

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Is Liquid Biopsy Only Restricted to Diagnostics or Can it Go Beyond the Confines of Genotyping and Phenotyping for Quantitative Pharmacology?

Clinical pharmacology and therapeutics, 2022-12, Vol.112 (6), p.1152-1153

2022

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A proposal for scientific framework enabling specific population drug dosing recommendations

Journal of clinical pharmacology, 2015-10, Vol.55 (10), p.1073-1078

2015

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Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature

Journal of clinical pharmacology, 2013-05, Vol.53 (5), p.559-566

2013

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Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

CPT: pharmacometrics and systems pharmacology, 2021-05, Vol.10 (5), p.467-477

2021

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Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling

CPT: pharmacometrics and systems pharmacology, 2019-02, Vol.8 (2), p.118-126

2019

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Virtual Twins: Understanding the Data Required for Model‐Informed Precision Dosing

Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment

Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading

Physiological‐based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20‐years; in‐depth analysis of applications, organizations, and platforms

Linking in vitro–in vivo extrapolations with physiologically based modeling to inform drug and formulation development

Scientific considerations to move towards biowaiver for biopharmaceutical classification system class III drugs: How modeling and simulation can help

Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence

Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

In-depth analysis of patterns in selection of different physiologically-based pharmacokinetic modeling tools: Part II - Assessment of model reusability and comparison between open and non-open source-code software

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

Identification and quantification of blood–brain barrier transporters in isolated rat brain microvessels

In‐depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I – Applications and rationale behind the use of open source‐code software

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19

Does “Birth” as an Event Impact Maturation Trajectory of Renal Clearance via Glomerular Filtration? Reexamining Data in Preterm and Full‐Term Neonates by Avoiding the Creatinine Bias

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate

Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults

Seeing what is behind the smokescreen: A systematic review of methodological aspects of smoking interaction studies over the last three decades and implications for future clinical trials

GASP and FASP are Complementary for LC–MS/MS Proteomic Analysis of Drug‐Metabolizing Enzymes and Transporters in Pig Liver

Is Liquid Biopsy Only Restricted to Diagnostics or Can it Go Beyond the Confines of Genotyping and Phenotyping for Quantitative Pharmacology?

A proposal for scientific framework enabling specific population drug dosing recommendations

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling

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