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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

Nature reviews. Drug discovery, 2007-02, Vol.6 (2), p.140-148

2007

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A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

Clinical pharmacokinetics, 2014-07, Vol.53 (7), p.625-636

2014

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Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

Clinical pharmacokinetics, 2006-01, Vol.45 (9), p.931-956

2006

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A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

Clinical pharmacokinetics, 2010-03, Vol.49 (3), p.189-206

2010

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Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults

Biopharmaceutics & drug disposition, 2015-05, Vol.36 (4), p.245-257

2015

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In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism

Drug metabolism and disposition, 2015-11, Vol.43 (11), p.1806-1814

2015

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Personalized Drug Dosage – Closing the Loop

Pharmaceutical research, 2017-08, Vol.34 (8), p.1539-1543

Tucker, Geoffrey T

2017

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Assessment of algorithms for predicting drug–drug interactions via inhibition mechanisms: comparison of dynamic and static models

British journal of clinical pharmacology, 2011-01, Vol.71 (1), p.72-87

2011

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Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling

Clinical pharmacokinetics, 2013-12, Vol.52 (12), p.1085-1100

2013

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Erratum to: A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

Clinical pharmacokinetics, 2015-06, Vol.54 (6), p.671-671

2015

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Was 4β‐hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?

British journal of clinical pharmacology, 2018-07, Vol.84 (7), p.1620-1621

2018

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Letter to the editor about reporting drug concentrations and pharmacokinetics in regional anesthesia and pain medicine

Regional anesthesia and pain medicine, 2024-02, Vol.49 (2), p.151

2024

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When Regional Anesthesia Met Pharmacokinetics

Anesthesiology (Philadelphia), 2022-04, Vol.136 (4), p.588-593

2022

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Metformin disposition—A 40‐year‐old mystery

British journal of clinical pharmacology, 2020-08, Vol.86 (8), p.1452-1453

2020

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Comment on: “The pharmacokinetics of metformin in patients receiving intermittent haemodialysis” by Sinnappah et al

British journal of clinical pharmacology, 2021-08, Vol.87 (8), p.3370-3371

2021

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Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia

Biochemical pharmacology, 2017-04, Vol.129, p.85-95

2017

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Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA

Journal of psychopharmacology (Oxford), 2006-11, Vol.20 (6), p.842-849

2006

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The British Journal of Clinical Pharmacology: The first 50 years

British journal of clinical pharmacology, 2024-01, Vol.90 (1), p.4-11

2024

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Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation

British journal of clinical pharmacology, 2018-03, Vol.84 (3), p.462-476

2018

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A series acceleration algorithm for the gamma-Pareto (type I) convolution and related functions of interest for pharmacokinetics

Journal of pharmacokinetics and pharmacodynamics, 2022-04, Vol.49 (2), p.191-208

2022

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Physiologically based pharmacokinetic-pharmacodynamic modeling to the rescue: understanding how resuscitation from local anesthetic overdose with lipid emulsions works

Anesthesiology (Philadelphia), 2014-04, Vol.120 (4), p.795-796

Tucker, Geoffrey T

2014

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Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

European journal of pharmaceutical sciences, 2010-03, Vol.39 (5), p.298-309

2010

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Prediction of intestinal first-pass drug metabolism

Current drug metabolism, 2007-10, Vol.8 (7), p.676

2007

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Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions

Current drug metabolism, 2008-06, Vol.9 (5), p.384

2008

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Research priorities in pharmacokinetics

British journal of clinical pharmacology, 2012-06, Vol.73 (6), p.924-926

Tucker, Geoffrey T

2012

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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults

In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism

Personalized Drug Dosage – Closing the Loop

Assessment of algorithms for predicting drug–drug interactions via inhibition mechanisms: comparison of dynamic and static models

Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling

Erratum to: A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

Was 4β‐hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?

Letter to the editor about reporting drug concentrations and pharmacokinetics in regional anesthesia and pain medicine

When Regional Anesthesia Met Pharmacokinetics

Metformin disposition—A 40‐year‐old mystery

Comment on: “The pharmacokinetics of metformin in patients receiving intermittent haemodialysis” by Sinnappah et al

Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA

The British Journal of Clinical Pharmacology: The first 50 years

Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation

A series acceleration algorithm for the gamma-Pareto (type I) convolution and related functions of interest for pharmacokinetics

Physiologically based pharmacokinetic-pharmacodynamic modeling to the rescue: understanding how resuscitation from local anesthetic overdose with lipid emulsions works

Physiologically based mechanistic modelling to predict complex drug–drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut—The effect of diltiazem on the time-course of exposure to triazolam

Prediction of intestinal first-pass drug metabolism

Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions

Research priorities in pharmacokinetics

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