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Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

Pain (Amsterdam), 2008-05, Vol.136 (1), p.202-210

2008

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Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium

American Journal of Physiology: Cell Physiology, 2014-06, Vol.306 (12), p.C1184-C1190

2014

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Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys

The AAPS journal, 2010-12, Vol.12 (4), p.646-657

2010

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Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth

Molecular cancer therapeutics, 2010-08, Vol.9 (8), p.2399-2410

2010

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Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS

Journal of pharmacological and toxicological methods, 2009-05, Vol.59 (3), p.171-180

2009

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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays

Pharmaceutical research, 2007-10, Vol.24 (10), p.1962-1973

2007

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Evaluation of microdosing strategies for studies in preclinical drug development: demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose range

Drug metabolism and disposition, 2004-11, Vol.32 (11), p.1254

2004

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Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-04, Vol.818 (2), p.241-248

2005

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Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline

Journal of medicinal chemistry, 2009-10, Vol.52 (20), p.6189-6192

2009

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Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

Journal of medicinal chemistry, 2008-05, Vol.51 (9), p.2758-2765

2008

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Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI)

Blood cells, molecules, & diseases, 2010-10, Vol.45 (3), p.238-245

2010

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Validation of a method for the determination of AMG 579 in cerebrospinal fluid with a focus on sample collection procedures for clinical trials

Journal of pharmaceutical and biomedical analysis, 2015-04, Vol.108, p.49-55

2015

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Platelets are essential for leukocyte recruitment in allergic inflammation

Journal of allergy and clinical immunology, 2003-07, Vol.112 (1), p.109-118

2003

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Development of a method for the determination of glycine in human cerebrospinal fluid using pre-column derivatization and LC–MS/MS

Journal of pharmaceutical and biomedical analysis, 2011-09, Vol.56 (2), p.315-323

2011

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Bioanalytical Method Validation: Concepts, Expectations and Challenges in Small Molecule and Macromolecule—A Report of PITTCON 2013 Symposium

The AAPS journal, 2014-05, Vol.16 (3), p.586-591

2014

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Direct Quantitative Analysis of a 20 kDa PEGylated Human Calcitonin Gene Peptide Antagonist in Cynomolgus Monkey Serum Using In-Source CID and UPLC-MS/MS

Journal of the American Society for Mass Spectrometry, 2011-09, Vol.22 (9), p.1660-1667

2011

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Targeted Learning: Causal Inference for Observational and Experimental Data

1. Aufl., 2011

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Single- and Multiple-Dose Pharmacokinetics of Etoricoxib, a Selective Inhibitor of Cyclooxygenase-2, in Man

Journal of clinical pharmacology, 2003-03, Vol.43 (3), p.268-276

2003

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GB5121, a Brain-Penetrant, Irreversible BTK Inhibitor, Demonstrates Potent Anti-Tumor Activity in a Novel Mouse Model of Intracranial Lymphoma

Blood, 2022-11, Vol.140 (Supplement 1), p.8878-8879

2022

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Workshop/conference report—Quantitative bioanalytical methods validation and implementation: Best practices for chromatographic and ligand binding assays

The AAPS journal, 2007-02, Vol.9 (1), p.E30-E42

2007

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Safety, Tolerability, and Pharmacokinetic Profile of Single and Multiple Ascending Doses of GB5121, a CNS-Penetrant BTK Inhibitor, in Healthy Subjects

Blood, 2022-11, Vol.140 (Supplement 1), p.11570-11571

2022

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Trial in Progress: A Phase 1b/2 Study of GB5121, a Brain-Penetrant, Potent, Highly Selective, and Irreversible BTK Inhibitor for Relapsed/Refractory Primary/Secondary CNS Lymphoma and Primary Vitreoretinal Lymphoma

Blood, 2022-11, Vol.140 (Supplement 1), p.12068-12069

2022

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Determination of potato carboxypeptidase inhibitor in African Green Monkey plasma using 96-well SPE and LC–MS/MS

Journal of pharmaceutical and biomedical analysis, 2005-07, Vol.38 (4), p.695-702

2005

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Pharmacokinetics of Etoricoxib in Patients with Hepatic Impairment

Journal of clinical pharmacology, 2003-10, Vol.43 (10), p.1136-1148

2003

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Amino acid and peptide analysis using derivatization with p-nitrophenol-2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ether and capillary electrophoresis with electrochemical detection

Journal of pharmaceutical and biomedical analysis, 2003-01, Vol.30 (6), p.1851-1859

2003

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Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium

Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys

Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth

Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS

Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays

Evaluation of microdosing strategies for studies in preclinical drug development: demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose range

Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine

Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline

Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity

Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI)

Validation of a method for the determination of AMG 579 in cerebrospinal fluid with a focus on sample collection procedures for clinical trials

Platelets are essential for leukocyte recruitment in allergic inflammation

Development of a method for the determination of glycine in human cerebrospinal fluid using pre-column derivatization and LC–MS/MS

Bioanalytical Method Validation: Concepts, Expectations and Challenges in Small Molecule and Macromolecule—A Report of PITTCON 2013 Symposium

Direct Quantitative Analysis of a 20 kDa PEGylated Human Calcitonin Gene Peptide Antagonist in Cynomolgus Monkey Serum Using In-Source CID and UPLC-MS/MS

Targeted Learning: Causal Inference for Observational and Experimental Data

Single- and Multiple-Dose Pharmacokinetics of Etoricoxib, a Selective Inhibitor of Cyclooxygenase-2, in Man

GB5121, a Brain-Penetrant, Irreversible BTK Inhibitor, Demonstrates Potent Anti-Tumor Activity in a Novel Mouse Model of Intracranial Lymphoma

Workshop/conference report—Quantitative bioanalytical methods validation and implementation: Best practices for chromatographic and ligand binding assays

Safety, Tolerability, and Pharmacokinetic Profile of Single and Multiple Ascending Doses of GB5121, a CNS-Penetrant BTK Inhibitor, in Healthy Subjects

Trial in Progress: A Phase 1b/2 Study of GB5121, a Brain-Penetrant, Potent, Highly Selective, and Irreversible BTK Inhibitor for Relapsed/Refractory Primary/Secondary CNS Lymphoma and Primary Vitreoretinal Lymphoma

Determination of potato carboxypeptidase inhibitor in African Green Monkey plasma using 96-well SPE and LC–MS/MS

Pharmacokinetics of Etoricoxib in Patients with Hepatic Impairment

Amino acid and peptide analysis using derivatization with p-nitrophenol-2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ether and capillary electrophoresis with electrochemical detection

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