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Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain

Acta neuropathologica, 2021-06, Vol.141 (6), p.823-839

2021

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Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

Nature reviews. Drug discovery, 2012-04, Vol.11 (4), p.292-310

2012

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Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules

European journal of medicinal chemistry, 2022-10, Vol.240, p.114578-114578, Article 114578

2022

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Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

Nature (London), 2000-02, Vol.403 (6772), p.916-921

2000

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Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Nature (London), 1997-08, Vol.388 (6642), p.586-589

1997

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Brain Renin-Angiotensin System Blockade by Systemically Active Aminopeptidase A Inhibitors: A Potential Treatment of Salt-Dependent Hypertension

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (20), p.7775-7780

2004

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Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice

British journal of pharmacology, 2003-11, Vol.140 (5), p.831-838

2003

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Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor–Blocked Rats

Hypertension (Dallas, Tex. 1979), 2007-03, Vol.49 (3, Part 2 Suppl), p.625-630

2007

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Destabilization of the HIV-1 Complementary Sequence of TAR by the Nucleocapsid Protein Through Activation of Conformational Fluctuations

Journal of molecular biology, 2003-02, Vol.326 (3), p.691-700

2003

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HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence

Journal of molecular biology, 2002-03, Vol.317 (3), p.385-399

2002

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The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain

Biochemical journal, 2005-04, Vol.387 (Pt 2), p.333-341

2005

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The Annealing Mechanism of HIV-1 Reverse Transcription Primer onto the Viral Genome

The Journal of biological chemistry, 2004-01, Vol.279 (5), p.3588-3595

2004

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Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

The FASEB journal, 2012-12, Vol.26 (12), p.5161-5171

2012

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Mechanisms That Prevent Template Inactivation by HIV-1 Reverse Transcriptase RNase H Cleavages

The Journal of biological chemistry, 2007-04, Vol.282 (17), p.12598-12609

2007

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Insights into the Multiple Roles of Pausing in HIV-1 Reverse Transcriptase-promoted Strand Transfers

The Journal of biological chemistry, 2007-03, Vol.282 (9), p.6222-6231

2007

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Detection and Quantification of Botulinum Neurotoxin Type A by a Novel Rapid In Vitro Fluorimetric Assay

Applied and Environmental Microbiology, 2009-07, Vol.75 (13), p.4382-4390

2009

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Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug

Clinical pharmacokinetics, 2014-04, Vol.53 (4), p.385-395

2014

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Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 2012-08, Vol.60 (2), p.411-418

2012

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Apparent Defects in Processive DNA Synthesis, Strand Transfer, and Primer Elongation of Met-184 Mutants of HIV-1 Reverse Transcriptase Derive Solely from a dNTP Utilization Defect

The Journal of biological chemistry, 2008-04, Vol.283 (14), p.9196-9205

2008

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New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5748-5763

2014

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Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins

Delta Opioid Receptor Pharmacology and Therapeutic Applications, 2018, Vol.247, p.53-70

2018

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Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain

European journal of pharmacology, 2016-10, Vol.788, p.176-182

2016

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Template Dimerization Promotes an Acceptor Invasion-Induced Transfer Mechanism during Human Immunodeficiency Virus Type 1 Minus-Strand Synthesis

Journal of Virology, 2003-04, Vol.77 (8), p.4710-4721

2003

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Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum

The Journal of neuroscience, 2014-01, Vol.34 (3), p.1057-1066

2014

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Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain

Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules

Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Brain Renin-Angiotensin System Blockade by Systemically Active Aminopeptidase A Inhibitors: A Potential Treatment of Salt-Dependent Hypertension

Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice

Intrarenal Aminopeptidase N Inhibition Augments Natriuretic Responses to Angiotensin III in Angiotensin Type 1 Receptor–Blocked Rats

Destabilization of the HIV-1 Complementary Sequence of TAR by the Nucleocapsid Protein Through Activation of Conformational Fluctuations

HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence

The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain

The Annealing Mechanism of HIV-1 Reverse Transcription Primer onto the Viral Genome

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

Mechanisms That Prevent Template Inactivation by HIV-1 Reverse Transcriptase RNase H Cleavages

Insights into the Multiple Roles of Pausing in HIV-1 Reverse Transcriptase-promoted Strand Transfers

Detection and Quantification of Botulinum Neurotoxin Type A by a Novel Rapid In Vitro Fluorimetric Assay

Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug

Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

Apparent Defects in Processive DNA Synthesis, Strand Transfer, and Primer Elongation of Met-184 Mutants of HIV-1 Reverse Transcriptase Derive Solely from a dNTP Utilization Defect

New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment

Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins

Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain

Template Dimerization Promotes an Acceptor Invasion-Induced Transfer Mechanism during Human Immunodeficiency Virus Type 1 Minus-Strand Synthesis

Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum

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