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TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

PLoS pathogens, 2018-03, Vol.14 (3), p.e1006939

2018

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Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

Cell, 2021-08, Vol.184 (17), p.4579-4592.e24

2021

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The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

Cell stem cell, 2020-04, Vol.26 (4), p.482-502

2020

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Weak links: Advancing target‐based drug discovery by identifying the most vulnerable targets

Annals of the New York Academy of Sciences, 2024-05, Vol.1535 (1), p.10-19

2024

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Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Nature microbiology, 2017-02, Vol.2 (4), p.16274, Article 16274

2017

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High-Flow Nasal Cannula Oxygen in Patients Having Anesthesia for Advanced Esophagogastroduodenoscopy: HIFLOW-ENDO, a Randomized Clinical Trial

Anesthesia and analgesia, 2021-03, Vol.132 (3), p.743-751

2021

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CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

Nature microbiology, 2022-06, Vol.7 (6), p.766-779

2022

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CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A

mBio, 2022-02, Vol.13 (1), p.e0368321-e0368321

2022

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Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (9), p.3055-3060

2007

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Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2022-09, Vol.66 (9), p.e0090422

2022

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A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens

PLoS computational biology, 2024-05, Vol.20 (5), p.e1011408

2024

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Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria

mBio, 2019-06, Vol.10 (3)

2019

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Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios

Gut, 2013-01, Vol.62 (1), p.73-82

2013

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Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes

Science (American Association for the Advancement of Science), 2013-05, Vol.340 (6134), p.871-875

2013

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Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (25), p.6464-6469

2018

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Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

PLoS pathogens, 2019-06, Vol.15 (6), p.e1007846-e1007846

2019

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Nature, 2005-06, Vol.435 (7042), p.646-651

2005

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Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis

Nature (London), 2024-04, Vol.628 (8006), p.186-194

2024

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Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction

PLoS computational biology, 2016-02, Vol.12 (2), p.e1004495-e1004495

2016

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Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria

Cell chemical biology, 2024-04, Vol.31 (4), p.669-682.e7

2024

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DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

Nature genetics, 2015-06, Vol.47 (6), p.677-681

2015

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Iron limitation in M. tuberculosis has broad impact on central carbon metabolism

Communications biology, 2022-07, Vol.5 (1), p.685-685, Article 685

2022

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The Effects of Rest on Concussion Symptom Resolution and Recovery Time: A Meta-analytic Review and Subgroup Analysis of 4329 Patients

The American journal of sports medicine, 2023-12, Vol.51 (14), p.3893-3903

2023

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The Tuberculosis Drug Accelerator at year 10: what have we learned?

The TB Drug Accelerator at Year Ten: What Have We Learned?

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

Weak links: Advancing target‐based drug discovery by identifying the most vulnerable targets

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

High-Flow Nasal Cannula Oxygen in Patients Having Anesthesia for Advanced Esophagogastroduodenoscopy: HIFLOW-ENDO, a Randomized Clinical Trial

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A

Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis

A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria

Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios

Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes

Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response

Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis

Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction

Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria

DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

Iron limitation in M. tuberculosis has broad impact on central carbon metabolism

The Effects of Rest on Concussion Symptom Resolution and Recovery Time: A Meta-analytic Review and Subgroup Analysis of 4329 Patients

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