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TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

PLoS pathogens, 2018-03, Vol.14 (3), p.e1006939

2018

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Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Nature microbiology, 2017-02, Vol.2 (4), p.16274, Article 16274

2017

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Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis

Frontiers in cellular and infection microbiology, 2022-10, Vol.12, p.997283-997283

2022

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CRISPY-BRED and CRISPY-BRIP: efficient bacteriophage engineering

Scientific reports, 2021-03, Vol.11 (1), p.6796-6796, Article 6796

2021

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CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

Nature microbiology, 2022-06, Vol.7 (6), p.766-779

2022

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Precise genome modification in the crop species Zea mays using zinc-finger nucleases

Nature, 2009-05, Vol.459 (7245), p.437-441

2009

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CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A

mBio, 2022-02, Vol.13 (1), p.e0368321-e0368321

2022

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Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria

mBio, 2019-06, Vol.10 (3)

2019

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Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (9), p.3055-3060

2007

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Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes

Science (American Association for the Advancement of Science), 2013-05, Vol.340 (6134), p.871-875

2013

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Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

PLoS pathogens, 2019-06, Vol.15 (6), p.e1007846-e1007846

2019

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Iron limitation in M. tuberculosis has broad impact on central carbon metabolism

Communications biology, 2022-07, Vol.5 (1), p.685-685, Article 685

2022

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Weak links: Advancing target‐based drug discovery by identifying the most vulnerable targets

Annals of the New York Academy of Sciences, 2024-05, Vol.1535 (1), p.10-19

2024

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Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

Cell, 2021-08, Vol.184 (17), p.4579-4592.e24

2021

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Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome

Nature (London), 2024-03, Vol.627 (8003), p.424-430

2024

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Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2022-09, Vol.66 (9), p.e0090422

2022

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Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit

Genes & development, 2011-09, Vol.25 (18), p.1943-1954

2011

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Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (25), p.6464-6469

2018

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The FEAR network

Current biology, 2009-12, Vol.19 (23), p.R1063-R1068

2009

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Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria

Cell chemical biology, 2024-04, Vol.31 (4), p.669-682.e7

2024

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Nature, 2005-06, Vol.435 (7042), p.646-651

2005

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Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis

Nature (London), 2024-04, Vol.628 (8006), p.186-194

2024

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DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

Nature genetics, 2015-06, Vol.47 (6), p.677-681

2015

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Targeted transgene integration in plant cells using designed zinc finger nucleases

Plant molecular biology, 2009-04, Vol.69 (6), p.699-709

2009

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TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis

CRISPY-BRED and CRISPY-BRIP: efficient bacteriophage engineering

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

CRISPR Interference Reveals That All- Trans -Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria

Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes

Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

Iron limitation in M. tuberculosis has broad impact on central carbon metabolism

Weak links: Advancing target‐based drug discovery by identifying the most vulnerable targets

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

Incomplete transcripts dominate the Mycobacterium tuberculosis transcriptome

Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis

Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit

Small RNA profiling in Mycobacterium tuberculosis identifies MrsI as necessary for an anticipatory iron sparing response

The FEAR network

Beyond antibiotic resistance: The whiB7 transcription factor coordinates an adaptive response to alanine starvation in mycobacteria

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

Targeted transgene integration in plant cells using designed zinc finger nucleases

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