UB Paderborn / Katalog / Suche / in CDI

1 – 20 von 20

Sortiert nach

GDC-0449—A potent inhibitor of the hedgehog pathway

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5576-5581

2009

Volltextzugriff (PDF)

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479

Bioorganic & medicinal chemistry letters, 2014-10, Vol.24 (19), p.4714-4723

2014

Volltextzugriff (PDF)

A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (18), p.5097-5104

2013

Volltextzugriff (PDF)

Potent, Selective, and Orally Bioavailable Inhibitors of Mammalian Target of Rapamycin (mTOR) Kinase Based on a Quaternary Substituted Dihydrofuropyrimidine

Journal of medicinal chemistry, 2011-05, Vol.54 (9), p.3426-3435

2011

Volltextzugriff (PDF)

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6748-6753

2010

Volltextzugriff (PDF)

Accelerated inverse electron demand Diels-Alder reactions of 1-oxa-1,3-butadienes: [4 + 2] cycloaddition reactions of .beta.,.gamma.-unsaturated .alpha.-keto esters

Journal of organic chemistry, 1988-07, Vol.53 (14), p.3373-3377

1988

Volltextzugriff (PDF)

From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold

Journal of the American Chemical Society, 1994-06, Vol.116 (12), p.5077-5083

1994

Volltextzugriff (PDF)

Divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder reaction of 1-oxa-1,3-butadienes

Journal of organic chemistry, 1988-11, Vol.53 (24), p.5793-5796

1988

Volltextzugriff (PDF)

From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1H-1,4-benzodiazepine-2,5-dione Nucleus

Journal of medicinal chemistry, 1997-02, Vol.40 (5), p.717-729

1997

Volltextzugriff (PDF)

Mono-N-alkylation of anthranilamides via quinazolinones. An efficient synthesis of G5598, a benzodiazepine dione gpIIbIIIa antagonist

Tetrahedron letters, 1994-04, Vol.35 (14), p.2113-2116

1994

Volltextzugriff (PDF)

Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (2), p.771-771

2010

Volltextzugriff (PDF)

Stability of alkoxycarbonylamidine prodrugs

Pharmaceutical research, 1998-03, Vol.15 (3), p.434-441

1998

Volltextzugriff (PDF)

Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists

Bioorganic & medicinal chemistry, 1998-12, Vol.6 (12), p.2345-2381

1998

Volltextzugriff (PDF)

From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1 H -1,4-benzodiazepine-2,5-dione Nucleus

Journal of medicinal chemistry, 1997-02, Vol.40 (5), p.717-729

1997

Volltextzugriff (PDF)

Stereoselectivity in electrophile-mediated intramolecular cyclizations of hept-2-enitols

Journal of organic chemistry, 1989-01, Vol.54 (2), p.346-359

1989

Volltextzugriff (PDF)

Stereoselectivity in the electrophile-mediated cyclization of 2,3,5-tri- O-benzyl-1,2-dideoxy- d- arabino-hex-1-enitol. A stereocontrolled synthesis of 1-amino-2,5-anhydro-3,4,6-tri- O-benzyl-1-deoxy- d-glucitol

Carbohydrate research, 1987-12, Vol.171 (1), p.1-11

1987

Volltextzugriff (PDF)

Epimerization at C-2 during the Wittig reaction of 2,3,5-tri- O-benzyl- d-ribose and methylidenetriphenylphosphorane

Carbohydrate research, 1986-10, Vol.154 (1), p.270-274

1986

Volltextzugriff (PDF)

Electrophile-mediated cyclizations of 6- O-benzyl-1,2-di- deoxy-3,4- O-isopropylidene- d- ribo-hex-1-enitol to derivatives of 2,5-anhydro-6- O-benzyl-3,4- O-isopropylidene- d- altro-hexitol

Carbohydrate research, 1985-01, Vol.137, p.89-97

1985

Volltextzugriff (PDF)

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Cancer research (Chicago, Ill.), 2011-01, Vol.71 (2), p.435-444

2011

Volltextzugriff (PDF)

A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

The Journal of biological chemistry, 2005-03, Vol.280 (10), p.9160-9169

2005

Volltextzugriff (PDF)

1 – 20 von 20

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(20)
Mit Volltextzugriff
(20)

Publikationsform

Artikel
(20)

Sprache

Englisch
(20)
Japanisch
(4)

Erscheinungsjahr

n.n

Thema

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

GDC-0449—A potent inhibitor of the hedgehog pathway

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479

A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors

Potent, Selective, and Orally Bioavailable Inhibitors of Mammalian Target of Rapamycin (mTOR) Kinase Based on a Quaternary Substituted Dihydrofuropyrimidine

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Accelerated inverse electron demand Diels-Alder reactions of 1-oxa-1,3-butadienes: [4 + 2] cycloaddition reactions of .beta.,.gamma.-unsaturated .alpha.-keto esters

From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold

Divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder reaction of 1-oxa-1,3-butadienes

From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1H-1,4-benzodiazepine-2,5-dione Nucleus

Mono-N-alkylation of anthranilamides via quinazolinones. An efficient synthesis of G5598, a benzodiazepine dione gpIIbIIIa antagonist

Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]

Stability of alkoxycarbonylamidine prodrugs

Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists

From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1 H -1,4-benzodiazepine-2,5-dione Nucleus

Stereoselectivity in electrophile-mediated intramolecular cyclizations of hept-2-enitols

Stereoselectivity in the electrophile-mediated cyclization of 2,3,5-tri- O-benzyl-1,2-dideoxy- d- arabino-hex-1-enitol. A stereocontrolled synthesis of 1-amino-2,5-anhydro-3,4,6-tri- O-benzyl-1-deoxy- d-glucitol

Epimerization at C-2 during the Wittig reaction of 2,3,5-tri- O-benzyl- d-ribose and methylidenetriphenylphosphorane

Electrophile-mediated cyclizations of 6- O-benzyl-1,2-di- deoxy-3,4- O-isopropylidene- d- ribo-hex-1-enitol to derivatives of 2,5-anhydro-6- O-benzyl-3,4- O-isopropylidene- d- altro-hexitol

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

Suchergebnisse filtern