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502 Preclinical Pharmacokinetics and Efficacy Assessment of a Potent and Selective MEK Inhibitor, GDC-0623

European journal of cancer (1990), 2012-11, Vol.48, p.155-155

2012

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Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

Xenobiotica, 2009-11, Vol.39 (11), p.850-861

2009

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From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1H-1,4-benzodiazepine-2,5-dione Nucleus

Journal of medicinal chemistry, 1997-02, Vol.40 (5), p.717-729

1997

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Abstract 466: A potential pro-oncogenic role of SERPINB4 in melanoma

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.466-466

2023

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Stability of alkoxycarbonylamidine prodrugs

Pharmaceutical research, 1998-03, Vol.15 (3), p.434-441

1998

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Stereoselectivity in electrophile-mediated intramolecular cyclizations of hept-2-enitols

Journal of organic chemistry, 1989-01, Vol.54 (2), p.346-359

1989

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A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

The Journal of biological chemistry, 2005-03, Vol.280 (10), p.9160-9169

2005

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Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists

Bioorganic & medicinal chemistry, 1998-12, Vol.6 (12), p.2345-2381

1998

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Mono-N-alkylation of anthranilamides via quinazolinones. An efficient synthesis of G5598, a benzodiazepine dione gpIIbIIIa antagonist

Tetrahedron letters, 1994-04, Vol.35 (14), p.2113-2116

1994

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Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro- N -(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

Xenobiotica, 2009-09, p.90908054849067-12

2009

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Stereoselectivity in the electrophile-mediated cyclization of 2,3,5-tri- O-benzyl-1,2-dideoxy- d- arabino-hex-1-enitol. A stereocontrolled synthesis of 1-amino-2,5-anhydro-3,4,6-tri- O-benzyl-1-deoxy- d-glucitol

Carbohydrate research, 1987-12, Vol.171 (1), p.1-11

1987

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Epimerization at C-2 during the Wittig reaction of 2,3,5-tri- O-benzyl- d-ribose and methylidenetriphenylphosphorane

Carbohydrate research, 1986-10, Vol.154 (1), p.270-274

1986

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Electrophile-mediated cyclizations in carbohydrate chemistry: synthesis of highly functionalized ribofuranose and ribopyranose compounds

Tetrahedron letters, 1985, Vol.26 (16), p.1943-1946

1985

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Pharmacokinetics, pharmacodynamics and tolerability of a potent, non-peptidic, GP IIb/IIIa receptor antagonist following multiple oral administrations of a prodrug form

Thrombosis and haemostasis, 1998-01, Vol.79 (1), p.169-176

1998

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Divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder reaction of 1-oxa-1,3-butadienes

Journal of organic chemistry, 1988-11, Vol.53 (24), p.5793-5796

1988

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Accelerated inverse electron demand Diels-Alder reactions of 1-oxa-1,3-butadienes: [4+2] cycloaddition reactions of β, α-unsaturated α-keto esters

Journal of organic chemistry, 1988, Vol.53 (14), p.3373-3377

1988

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Electrophile-mediated cyclizations in carbohydrate chemistry: synthesis of highly functionalized ribofuranose and ribopyranose compounds

Tetrahedron letters, 1985, Vol.26 (16), p.194-1946

1985

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Electrophile-mediated cyclizations of 6-O-benzyl-1,2-dideoxy-3,4-O-isopropylidene-D-ribo-hex-1-enitol to derivatives of 2,5-anhydro-6-O-benzyl-3,4-O-isopropylidene-D-altro-hexitol

Carbohydrate research, 1985, Vol.137, p.89-97

1985

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ChemInform Abstract: Stereoselectivity in the Electrophile‐Mediated Cyclization of 2,3,5‐Tri‐O‐benzyl‐1,2‐dideoxy‐D‐arabino‐hex‐1‐enitol. A Stereocontrolled Synthesis of 1‐Amino‐2,5‐anhydro‐3,4,6‐tri‐O‐benzyl‐1‐deoxy‐D‐glucitol

ChemInform, 1988-07, Vol.19 (28), p.no-no

1988

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ChemInform Abstract: Epimerization at C‐2 During the Wittig Reaction of 2,3,5‐Tri‐O‐benzyl‐ D‐ribose and Methylidenetriphenylphosphorane

ChemInform, 1987-05, Vol.18 (18), p.no-no

1987

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ChemInform Abstract: ELECTROPHILE‐MEDIATED CYCLIZATIONS OF 6‐O‐BENZYL‐1,2‐DIDEOXY‐3,4‐O‐ISOPROPYLIDENE‐D‐RIBO‐HEX‐1‐ENITOL TO DERIVATIVES OF 2,5‐ANHYDRO‐6‐O‐BENZYL‐3,4‐O‐ISOPROPYLIDENE‐D‐ALTRO‐HEXITOL

Chemischer Informationsdienst, 1985-09, Vol.16 (35)

1985

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ChemInform Abstract: ELECTROPHILE‐MEDIATED CYCLIZATIONS IN CARBOHYDRATE CHEMISTRY: SYNTHESIS OF HIGHLY FUNCTIONALIZED RIBOFURANOSE AND RIBOPYRANOSE COMPOUNDS

Chemischer Informationsdienst, 1985-08, Vol.16 (32)

1985

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ChemInform Abstract: A Divergent de Novo Synthesis of Carbohydrates Based on an Accelerated Inverse Electron Demand Diels‐Alder Reaction of 1‐Oxa‐1,3‐butadienes

ChemInform, 1989-05, Vol.20 (20), p.no-no

1989

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ChemInform Abstract: Accelerated Inverse Electron Demand Diels‐Alder Reactions of 1‐Oxa‐1,3‐butadienes: (4 + 2)Cycloaddition Reactions of β,γ‐Unsaturated α‐Keto Esters

ChemInform, 1988-12, Vol.19 (51), p.no-no

1988

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Transition-metal profiles in open and closed kraft fiber lines

Tappi journal, 1993, Vol.76 (10), p.148-159

1993

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502 Preclinical Pharmacokinetics and Efficacy Assessment of a Potent and Selective MEK Inhibitor, GDC-0623

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1H-1,4-benzodiazepine-2,5-dione Nucleus

Abstract 466: A potential pro-oncogenic role of SERPINB4 in melanoma

Stability of alkoxycarbonylamidine prodrugs

Stereoselectivity in electrophile-mediated intramolecular cyclizations of hept-2-enitols

A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo

Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists

Mono-N-alkylation of anthranilamides via quinazolinones. An efficient synthesis of G5598, a benzodiazepine dione gpIIbIIIa antagonist

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro- N -(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

Stereoselectivity in the electrophile-mediated cyclization of 2,3,5-tri- O-benzyl-1,2-dideoxy- d- arabino-hex-1-enitol. A stereocontrolled synthesis of 1-amino-2,5-anhydro-3,4,6-tri- O-benzyl-1-deoxy- d-glucitol

Epimerization at C-2 during the Wittig reaction of 2,3,5-tri- O-benzyl- d-ribose and methylidenetriphenylphosphorane

Electrophile-mediated cyclizations in carbohydrate chemistry: synthesis of highly functionalized ribofuranose and ribopyranose compounds

Pharmacokinetics, pharmacodynamics and tolerability of a potent, non-peptidic, GP IIb/IIIa receptor antagonist following multiple oral administrations of a prodrug form

Divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder reaction of 1-oxa-1,3-butadienes

Accelerated inverse electron demand Diels-Alder reactions of 1-oxa-1,3-butadienes: [4+2] cycloaddition reactions of β, α-unsaturated α-keto esters

Electrophile-mediated cyclizations in carbohydrate chemistry: synthesis of highly functionalized ribofuranose and ribopyranose compounds

Electrophile-mediated cyclizations of 6-O-benzyl-1,2-dideoxy-3,4-O-isopropylidene-D-ribo-hex-1-enitol to derivatives of 2,5-anhydro-6-O-benzyl-3,4-O-isopropylidene-D-altro-hexitol

ChemInform Abstract: Stereoselectivity in the Electrophile‐Mediated Cyclization of 2,3,5‐Tri‐O‐benzyl‐1,2‐dideoxy‐D‐arabino‐hex‐1‐enitol. A Stereocontrolled Synthesis of 1‐Amino‐2,5‐anhydro‐3,4,6‐tri‐O‐benzyl‐1‐deoxy‐D‐glucitol

ChemInform Abstract: Epimerization at C‐2 During the Wittig Reaction of 2,3,5‐Tri‐O‐benzyl‐ D‐ribose and Methylidenetriphenylphosphorane

ChemInform Abstract: ELECTROPHILE‐MEDIATED CYCLIZATIONS OF 6‐O‐BENZYL‐1,2‐DIDEOXY‐3,4‐O‐ISOPROPYLIDENE‐D‐RIBO‐HEX‐1‐ENITOL TO DERIVATIVES OF 2,5‐ANHYDRO‐6‐O‐BENZYL‐3,4‐O‐ISOPROPYLIDENE‐D‐ALTRO‐HEXITOL

ChemInform Abstract: ELECTROPHILE‐MEDIATED CYCLIZATIONS IN CARBOHYDRATE CHEMISTRY: SYNTHESIS OF HIGHLY FUNCTIONALIZED RIBOFURANOSE AND RIBOPYRANOSE COMPOUNDS

ChemInform Abstract: A Divergent de Novo Synthesis of Carbohydrates Based on an Accelerated Inverse Electron Demand Diels‐Alder Reaction of 1‐Oxa‐1,3‐butadienes

ChemInform Abstract: Accelerated Inverse Electron Demand Diels‐Alder Reactions of 1‐Oxa‐1,3‐butadienes: (4 + 2)Cycloaddition Reactions of β,γ‐Unsaturated α‐Keto Esters

Transition-metal profiles in open and closed kraft fiber lines

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