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Effects of Raf Dimerization and Its Inhibition on Normal and Disease-Associated Raf Signaling

Molecular cell, 2013-02, Vol.49 (4), p.751-758

2013

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Molecular cell, 2019-12, Vol.76 (6), p.872-884.e5

2019

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Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling

Molecular and Cellular Biology, 2010-02, Vol.30 (3), p.806-819

2010

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Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Molecular cell, 2016-12, Vol.64 (5), p.875-887

2016

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The CNK2 Scaffold Interacts with Vilse and Modulates Rac Cycling during Spine Morphogenesis in Hippocampal Neurons

Current biology, 2014-03, Vol.24 (7), p.786-792

2014

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Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

Developmental cell, 2019-07, Vol.50 (2), p.229-246.e7

2019

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M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell–cell adhesion during collective cell migration

Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (9), p.3536-3545

2019

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RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling

Current biology, 2011-04, Vol.21 (7), p.563-568

2011

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RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation

Molecular cell, 2022-11, Vol.82 (22), p.4262-4276.e5

2022

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Signaling dynamics of the KSR1 scaffold complex

Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (27), p.11022-11027

2009

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TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Cancer discovery, 2021-06, Vol.11 (6), p.1411-1423

2021

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Regulation of Raf-1 by Direct Feedback Phosphorylation

Molecular cell, 2005-01, Vol.17 (2), p.215-224

2005

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Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma

The Journal of biological chemistry, 2016-08, Vol.291 (34), p.17804-17815

2016

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The importance of Raf dimerization in cell signaling

Small GTPases, 2013-07, Vol.4 (3), p.180-185

2013

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KSR2 Is a Calcineurin Substrate that Promotes ERK Cascade Activation in Response to Calcium Signals

Molecular cell, 2009-06, Vol.34 (6), p.652-662

2009

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Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling

Journal of natural products (Washington, D.C.), 2018-07, Vol.81 (7), p.1666-1672

2018

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Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma

Cancer discovery, 2015-05, Vol.5 (5), p.534-549

2015

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Survival of BRCA2-Deficient Cells Is Promoted by GIPC3 , a Novel Genetic Interactor of BRCA2

Genetics (Austin), 2017-12, Vol.207 (4), p.1335-1345

2017

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CCAAT/enhancer binding protein delta (C/EBPδ, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (37), p.16131-16136

2010

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CK2 Is a Component of the KSR1 Scaffold Complex that Contributes to Raf Kinase Activation

Current biology, 2007-01, Vol.17 (2), p.179-184

2007

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Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

Frontiers in chemistry, 2018-09, Vol.6, p.434-434

2018

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Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate

The EMBO journal, 2003-09, Vol.22 (17), p.4431-4442

2003

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TNIK, a novel activator of FAK and YAP signaling, is a therapeutic target in Lung Squamous Cell Carcinoma

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.02752

2021

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Abstract A31: Germline RASopathy mutations provide functional insights into the Raf cysteine-rich domain (CRD)

Molecular cancer research, 2020-05, Vol.18 (5_Supplement), p.A31-A31

2020

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The protein kinase TNIK: a novel druggable target in Lung Squamous Cell Carcinoma with 3q amplification

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Effects of Raf Dimerization and Its Inhibition on Normal and Disease-Associated Raf Signaling

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

The CNK2 Scaffold Interacts with Vilse and Modulates Rac Cycling during Spine Morphogenesis in Hippocampal Neurons

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell–cell adhesion during collective cell migration

RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling

RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation

Signaling dynamics of the KSR1 scaffold complex

TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

Regulation of Raf-1 by Direct Feedback Phosphorylation

Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma

The importance of Raf dimerization in cell signaling

KSR2 Is a Calcineurin Substrate that Promotes ERK Cascade Activation in Response to Calcium Signals

Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling

Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma

Survival of BRCA2-Deficient Cells Is Promoted by GIPC3 , a Novel Genetic Interactor of BRCA2

CCAAT/enhancer binding protein delta (C/EBPδ, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage

CK2 Is a Component of the KSR1 Scaffold Complex that Contributes to Raf Kinase Activation

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate

TNIK, a novel activator of FAK and YAP signaling, is a therapeutic target in Lung Squamous Cell Carcinoma

Abstract A31: Germline RASopathy mutations provide functional insights into the Raf cysteine-rich domain (CRD)

The protein kinase TNIK: a novel druggable target in Lung Squamous Cell Carcinoma with 3q amplification

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