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CFTR function and prospects for therapy

Annual review of biochemistry, 2008-01, Vol.77 (1), p.701-726

Riordan, John R

2008

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Assembly of functional CFTR chloride channels

Annual review of physiology, 2005-01, Vol.67 (1), p.701-718

Riordan, John R

2005

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Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

The FASEB journal, 2012-02, Vol.26 (2), p.533-545

2012

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Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis

Cell, 2006-11, Vol.127 (4), p.803-815

2006

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Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

Proceedings of the National Academy of Sciences - PNAS, 2008-03, Vol.105 (9), p.3256-3261

2008

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Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Nature chemical biology, 2010-01, Vol.6 (1), p.25-33

2010

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Domain-interface dynamics of CFTR revealed by stabilizing nanobodies

Nature communications, 2019-06, Vol.10 (1), p.2636-12, Article 2636

2019

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Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures

American journal of physiology. Lung cellular and molecular physiology, 2010-03, Vol.298 (3), p.L304-L314

2010

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Transmembrane helical interactions in the CFTR channel pore

PLoS computational biology, 2017-06, Vol.13 (6), p.e1005594-e1005594

2017

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Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating

The Journal of biological chemistry, 2008-09, Vol.283 (39), p.26383-26390

2008

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COPII-Dependent Export of Cystic Fibrosis Transmembrane Conductance Regulator from the ER Uses a Di-Acidic Exit Code

The Journal of cell biology, 2004-10, Vol.167 (1), p.65-74

2004

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Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator

The Journal of physiology, 2009-06, Vol.587 (12), p.2875-2886

2009

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Purification and Crystallization of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

The Journal of biological chemistry, 2004-09, Vol.279 (37), p.39051-39057

2004

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Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A

Biochimica et biophysica acta, 2009-06, Vol.1788 (6), p.1341-1349

2009

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Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator

Journal of cell science, 2008-09, Vol.121 (17), p.2814-2823

2008

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The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover

The Journal of biological chemistry, 2002-05, Vol.277 (18), p.15419-15425

2002

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Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein

The FASEB journal, 2013-02, Vol.27 (2), p.536-545

2013

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Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast

Molecular biology of the cell, 2004-09, Vol.15 (9), p.4125-4135

2004

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Non-conventional Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator through the Early Secretory Pathway

The Journal of biological chemistry, 2002-03, Vol.277 (13), p.11401-11409

2002

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Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2)

Biochemical journal, 2008-11, Vol.416 (1), p.129-136

2008

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The PDZ-binding Chloride Channel ClC-3B Localizes to the Golgi and Associates with Cystic Fibrosis Transmembrane Conductance Regulator-interacting PDZ Proteins

The Journal of biological chemistry, 2003-02, Vol.278 (8), p.6440-6449

2003

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Restoration of NBD1 thermal stability is necessary and sufficient to correct ΔF508 CFTR folding and assembly

Journal of molecular biology, 2015-01, Vol.427 (1), p.106-120

2015

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Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel

Biochemistry (Easton), 2018-10, Vol.57 (43), p.6234-6246

2018

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R‑Domain Phosphorylation by Protein Kinase A Stimulates Dissociation of Unhydrolyzed ATP from the First Nucleotide-Binding Site of the Cystic Fibrosis Transmembrane Conductance Regulator

Biochemistry (Easton), 2018-08, Vol.57 (34), p.5073-5075

2018

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The cubicon method for concentrating membrane proteins in the cubic mesophase

Nature protocols, 2017-09, Vol.12 (9), p.1745-1762

2017

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CFTR function and prospects for therapy

Assembly of functional CFTR chloride channels

Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

Domain-interface dynamics of CFTR revealed by stabilizing nanobodies

Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures

Transmembrane helical interactions in the CFTR channel pore

Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel Gating

COPII-Dependent Export of Cystic Fibrosis Transmembrane Conductance Regulator from the ER Uses a Di-Acidic Exit Code

Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator

Purification and Crystallization of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A

Role of N-linked oligosaccharides in the biosynthetic processing of the cystic fibrosis membrane conductance regulator

The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover

Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein

Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast

Non-conventional Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator through the Early Secretory Pathway

Mg2+ -dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2)

The PDZ-binding Chloride Channel ClC-3B Localizes to the Golgi and Associates with Cystic Fibrosis Transmembrane Conductance Regulator-interacting PDZ Proteins

Restoration of NBD1 thermal stability is necessary and sufficient to correct ΔF508 CFTR folding and assembly

Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel

R‑Domain Phosphorylation by Protein Kinase A Stimulates Dissociation of Unhydrolyzed ATP from the First Nucleotide-Binding Site of the Cystic Fibrosis Transmembrane Conductance Regulator

The cubicon method for concentrating membrane proteins in the cubic mesophase

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