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Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

Journal of clinical pharmacology, 2010-04, Vol.50 (4), p.401-414

2010

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Echocardiographic examination in rats and mice

Methods in molecular biology (Clifton, N.J.), 2009-01, Vol.573, p.139

2009

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Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

Journal of translational medicine, 2014-12, Vol.12 (1), p.340-340, Article 340

2014

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Structure–Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors

Journal of medicinal chemistry, 2015-06, Vol.58 (11), p.4749-4770

2015

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Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation

European journal of pharmaceutical sciences, 2019-02, Vol.128, p.103-111

2019

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Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7099-7107

2017

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Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8466-8481

2017

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Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β 2 -Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies

The Journal of pharmacology and experimental therapeutics, 2019-05, Vol.369 (2), p.188-199

2019

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Discovery of N‑[5-(6-Chloro-3-cyano-1-methyl‑1H‑indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects

Journal of medicinal chemistry, 2015-12, Vol.58 (23), p.9382-9394

2015

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Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

The Journal of pharmacology and experimental therapeutics, 2017-02, Vol.360 (2), p.356-367

2017

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Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors

ACS medicinal chemistry letters, 2020-02, Vol.11 (2), p.188-194

2020

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Chronic measurement of left ventricular pressure in freely moving rats

Journal of applied physiology (1985), 2013-12, Vol.115 (11), p.1672-1682

2013

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The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2207-2217

2013

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trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (8), p.1787-1791

2015

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A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3 –P1 Pharmacophore

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2196-2206

2013

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Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1203-1207

2013

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Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

The Journal of biological chemistry, 1997-08, Vol.272 (32), p.19943-19950

1997

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Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors

ACS medicinal chemistry letters, 2014-07, Vol.5 (7), p.787-792

2014

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The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4324-4327

2010

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Pharmacodynamic and Pharmacokinetic Characterization of the Aldosterone Synthase Inhibitor FAD286 in Two Rodent Models of Hyperaldosteronism: Comparison with the 11β-Hydroxylase Inhibitor Metyrapone

The Journal of pharmacology and experimental therapeutics, 2010-07, Vol.334 (1), p.232-243

2010

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Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization

The Journal of thoracic and cardiovascular surgery, 2000-08, Vol.120 (2), p.350-358

2000

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A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P 3 – P 1 Pharmacophore

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2196-2206

2013

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Chronic recordings of cardiac contractility in conscious rats via telemetry

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Comparison of Hirudin and Heparin as Adjuncts to Streptokinase Thrombolysis in a Canine Model of Coronary Thrombosis

Circulation research, 1993-05, Vol.72 (5), p.1091-1102

1993

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Differential Responsiveness of Conduit and Resistance Coronary Arteries to Endothelin A and B Receptor Stimulation in Anesthetized Dogs

Journal of cardiovascular pharmacology, 1993, Vol.22 Suppl 8 (Supplement 8), p.S243-S247

1993

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Pharmacokinetics and Pharmacodynamics of LCZ696, a Novel Dual-Acting Angiotensin Receptor-Neprilysin Inhibitor (ARNi)

Echocardiographic examination in rats and mice

Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects

Structure–Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors

Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation

Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models

Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma

Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β 2 -Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies

Discovery of N‑[5-(6-Chloro-3-cyano-1-methyl‑1H‑indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects

Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors

Chronic measurement of left ventricular pressure in freely moving rats

The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches

trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker

A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3 –P1 Pharmacophore

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-β-hydroxylase

Pharmacodynamic and Pharmacokinetic Characterization of the Aldosterone Synthase Inhibitor FAD286 in Two Rodent Models of Hyperaldosteronism: Comparison with the 11β-Hydroxylase Inhibitor Metyrapone

Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization

A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P 3 – P 1 Pharmacophore

Chronic recordings of cardiac contractility in conscious rats via telemetry

Comparison of Hirudin and Heparin as Adjuncts to Streptokinase Thrombolysis in a Canine Model of Coronary Thrombosis

Differential Responsiveness of Conduit and Resistance Coronary Arteries to Endothelin A and B Receptor Stimulation in Anesthetized Dogs

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