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Pharmacokinetic characteristics of fentanyl iontophoretic trandermal system over a range of applied current

Expert opinion on drug metabolism & toxicology, 2015-04, Vol.11 (4), p.481-489

2015

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SAT-233 Clinical pharmacokinetics of INI-822, a small molecule inhibitor of HSD17B13

Journal of hepatology, 2024-06, Vol.80, p.S616-S616

2024

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Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching

Drug metabolism and disposition, 2005-12, Vol.33 (12), p.1837

2005

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Detection and Characterization of DNA Adducts of 3-Methylindole

Chemical research in toxicology, 2001-08, Vol.14 (8), p.1014-1024

2001

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Identification of 17-α-Ethynylestradiol-Modified Active Site Peptides and Glutathione Conjugates Formed during Metabolism and Inactivation of P450s 2B1 and 2B6

Chemical research in toxicology, 2006-02, Vol.19 (2), p.279-287

2006

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The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5544-5547

2010

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Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

Cancer chemotherapy and pharmacology, 2022-06, Vol.89 (6), p.737-750

2022

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Mechanism-Based Inactivation of Cytochrome P450 2B1 by 7-Ethynylcoumarin: Verification of Apo-P450 Adduction by Electrospray Ion Trap Mass Spectrometry

Chemical research in toxicology, 2000-04, Vol.13 (4), p.262-270

2000

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Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3379-3403

2013

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Orientation of Caffeine within the Active Site of Human Cytochrome P450 1A2 Based on NMR Longitudinal (T1) Relaxation Measurements

Archives of biochemistry and biophysics, 2000-12, Vol.384 (1), p.47-58

2000

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Subnanomolar quantification of caffeine's in vitro metabolites by stable isotope dilution gas chromatography–mass spectrometry

Journal of chromatography. B, Biomedical sciences and applications, 1998-04, Vol.708 (1), p.75-85

1998

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8‑Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.10112-10129

2014

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Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (14), p.3713-3718

2006

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Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing

Drug metabolism and disposition, 2013-07, Vol.41 (7), p.1319-1328

2013

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Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Ab1-40 and Ab1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

Archives of Pharmacal Research, 2014, 37(5), , pp.636-644

2014

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Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human $A{\beta}1$-40 and $A{\beta}1$-42 peptides in transgenic mouse plasma using

Archives of pharmacal research, 2014, Vol.37 (5), p.636-644

2014

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Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

Archives of pharmacal research, 2014-05, Vol.37 (5), p.636-644

2014

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Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp

European journal of drug metabolism and pharmacokinetics, 2015-06, Vol.40 (2), p.171-185

2015

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Abstract B267: AR-mTOR-1: A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.B267-B267

2009

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Abstract 4484: AR-mTOR-26 - A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4484-4484

2010

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Identification of 17- α-Ethynylestradiol Modified Active Site Peptides and Glutathione Conjugates Formed During Metabolism and Inactivation of P450s 2B1 and 2B61

Chemical research in toxicology, 2006-02, Vol.19 (2), p.279-287

2006

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Pharmacokinetics and Toxicokinetics

A Comprehensive Guide to Toxicology in Preclinical Drug Development, 2012

Faqi DVM, DABT, ATS, Ali S

2012

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Pharmacokinetic characteristics of fentanyl iontophoretic trandermal system over a range of applied current

SAT-233 Clinical pharmacokinetics of INI-822, a small molecule inhibitor of HSD17B13

Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching

Detection and Characterization of DNA Adducts of 3-Methylindole

Identification of 17-α-Ethynylestradiol-Modified Active Site Peptides and Glutathione Conjugates Formed during Metabolism and Inactivation of P450s 2B1 and 2B6

The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core

Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

Mechanism-Based Inactivation of Cytochrome P450 2B1 by 7-Ethynylcoumarin: Verification of Apo-P450 Adduction by Electrospray Ion Trap Mass Spectrometry

Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species

Orientation of Caffeine within the Active Site of Human Cytochrome P450 1A2 Based on NMR Longitudinal (T1) Relaxation Measurements

Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System

Subnanomolar quantification of caffeine's in vitro metabolites by stable isotope dilution gas chromatography–mass spectrometry

8‑Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing

Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation

Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Ab1-40 and Ab1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

Qualification and application of a liquid chromatography-tandem mass spectrometric method for the determination of human $A{\beta}1$-40 and $A{\beta}1$-42 peptides in transgenic mouse plasma using

Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors

Dose-dependent exposure and metabolism of GNE-892, a β-secretase inhibitor, in monkeys: contributions by P450, AO, and P-gp

Abstract B267: AR-mTOR-1: A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy

Abstract 4484: AR-mTOR-26 - A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy

Identification of 17- α-Ethynylestradiol Modified Active Site Peptides and Glutathione Conjugates Formed During Metabolism and Inactivation of P450s 2B1 and 2B61

Pharmacokinetics and Toxicokinetics

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