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Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms

Neuropharmacology, 2017-12, Vol.127, p.173-184

2017

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Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli

PloS one, 2013-05, Vol.8 (5), p.e63865-e63865

2013

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Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1

Neuropharmacology, 2017-12, Vol.127, p.185-195

2017

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Inhibition of voltage‐gated Na+ currents in sensory neurones by the sea anemone toxin APETx2

British journal of pharmacology, 2012-04, Vol.165 (7), p.2167-2177

2012

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Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Nature genetics, 2015-01, Vol.47 (1), p.73-77

2015

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Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

Frontiers in cellular neuroscience, 2021-09, Vol.15, p.738043-738043

2021

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The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant

PloS one, 2017-03, Vol.12 (3), p.e0173551

2017

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Spider-venom peptides as therapeutics

Toxins, 2010-12, Vol.2 (12), p.2851-2871

2010

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A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons

The EMBO journal, 2004-04, Vol.23 (7), p.1516-1525

2004

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Pharmacology and biochemistry of spider venoms

Toxicon, 2002-03, Vol.40 (3), p.225-254

2002

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Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future

Advances in pharmacology (1990), 2017, Vol.79, p.35-66

Rash, Lachlan D

2017

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A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid‐sensitive channel in sensory neurons

The EMBO journal, 2004-04, Vol.23 (7), p.1516-1525

2004

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NaV1.7 as a pain target – From gene to pharmacology

Pharmacology & therapeutics (Oxford), 2017-04, Vol.172, p.73-100

2017

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The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

The Journal of physiology, 2006-01, Vol.570 (2), p.339-354

2006

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D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels

Toxins, 2019-04, Vol.11 (4), p.197

2019

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Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (8)

2021

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The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution

Toxins, 2019-11, Vol.11 (11), p.666

2019

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The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity

Scientific reports, 2017-04, Vol.7 (1), p.974-15, Article 974

2017

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The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

Toxins, 2017-10, Vol.9 (11), p.346

2017

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Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Toxins, 2015-06, Vol.7 (7), p.2494-2513

2015

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Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Proceedings of the National Academy of Sciences - PNAS, 2017-04, Vol.114 (14), p.3750-3755

2017

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Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3

Marine drugs, 2012-07, Vol.10 (7), p.1605-1618

2012

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Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

Marine drugs, 2012-07, Vol.10 (7), p.1511-1527

2012

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Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans

Cellular and molecular life sciences : CMLS, 2018-12, Vol.75 (23), p.4465-4478

2018

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The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation

Biochemical pharmacology, 2024-10, Vol.228, p.116175, Article 116175

2024

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Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli

Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1

Inhibition of voltage‐gated Na+ currents in sensory neurones by the sea anemone toxin APETx2

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant

Spider-venom peptides as therapeutics

A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons

Pharmacology and biochemistry of spider venoms

Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future

A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid‐sensitive channel in sensory neurons

NaV1.7 as a pain target – From gene to pharmacology

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels

Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead

The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans

The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation

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