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Process Development of a Novel Azetidinyl Ketolide Antibiotic

Organic process research & development, 2012-05, Vol.16 (5), p.788-797

2012

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Pharmaceutical impurity identification: A case study using a multidisciplinary approach

Journal of pharmaceutical sciences, 2004-09, Vol.93 (9), p.2296-2309

2004

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Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling

Synthesis (Stuttgart), 2024-02, Vol.56 (4), p.686-692

2024

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A Scaleable Synthesis of 3-Hydroxy-1,5-naphthyridine-4-carbaldehyde

Synlett, 2010-01, Vol.2010 (2), p.250-252

2010

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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Organic process research & development, 2023-05, Vol.27 (5), p.854-865

2023

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Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination

Organic process research & development, 2024-10, Vol.28 (10), p.3801-3807

2024

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Furan-Terminated N-Acyliminium Ion Initiated Cyclizations in Alkaloid Synthesis

Journal of organic chemistry, 1998-10, Vol.63 (20), p.6914-6928

1998

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Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6)

Organic process research & development, 2024-06, Vol.28 (6), p.2247-2259

2024

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Exploratory Process Development of Lorlatinib

Organic process research & development, 2018-09, Vol.22 (9), p.1289-1293

2018

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Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Organic process research & development, 2021-06, Vol.25 (6), p.1440-1453

2021

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Continuous Production of Anhydrous tert-Butyl Hydroperoxide in Nonane Using Membrane Pervaporation and Its Application in Flow Oxidation of a γ‑Butyrolactam

Organic process research & development, 2018-06, Vol.22 (6), p.707-720

2018

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A Reliable Multikilogram-Scale Synthesis of 2-Acetamido-5-Vinylpyridine Using Catalytic BINAP in a Modified Heck Reaction

Organic process research & development, 2002-01, Vol.6 (1), p.67-69

2002

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Discovery of Two Clinical Histamine H 3 Receptor Antagonists: trans - N -Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans -3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]- N -(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7602-7620

2011

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Streamlined Processes for the Synthesis of a Farnesyl Transferase Inhibitor Drug Candidate

Organic process research & development, 2004-07, Vol.8 (4), p.643-650

2004

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Continuous flow aminolysis under high temperature and pressure

Journal of flow chemistry, 2020-03, Vol.10 (1), p.145-156

2020

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Pyrroles as terminators in cationic cyclizations. The preparation of 5,6,7,8-tetrahydroindolizidines and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepines

Journal of organic chemistry, 1987-03, Vol.52 (5), p.819-827

1987

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Novel Synthesis of 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea, an Anti-inflammatory Agent

Synthetic communications, 2003-07, Vol.33 (12), p.2029-2043

2003

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Process Research and Scale-Up for a β-3 Adrenergic Receptor Agonist

Organic process research & development, 2004-07, Vol.8 (4), p.583-586

2004

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ChemInform Abstract: A Reliable Multikilogram-Scale Synthesis of 2-Acetamido-5-vinylpyridine Using Catalytic BINAP in a Modified Heck Reaction

ChemInform, 2002-06, Vol.33 (23), p.no-no

2002

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A significant new product from the addition of dichlorocarbene to tetraphenylcyclone

Tetrahedron letters, 1983, Vol.24 (45), p.4891-4894

1983

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PREPARATION OF 4-CHLORO-2-THIOPHENECARBOXYLIC ACID via SELECTIVE BISULFITE SALT ADDITION PROCEDURE

Organic preparations and procedures international, 1995-04, Vol.27 (2), p.233-236

1995

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PART I. PYRROLES AS TERMINATORS IN CATIONIC CYCLIZATIONS. THE PREPARATION OF 5,6,7,8-TETRAHYDRO - INDOLIZIDINES AND 6,7,8,9-TETRAHYDRO-(5H)-PYRROLO(1,2A)-AZEPINES. PART II. STUDIES DIRECTED TOWARDS THE SYNTHESIS OF SIMPLE INDOLIZIDINE AND QUINOLIZIDINE ALKALOIDS (FURANS)

RAGGON, JEFFREY WILLIAM

1986

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AN EXAMPLE OF A 1,4-CARBENE ADDITION

RAGGON, JEFFREY WILLIAM

1983

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Process Development of a Novel Azetidinyl Ketolide Antibiotic

Pharmaceutical impurity identification: A case study using a multidisciplinary approach

Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling

A Scaleable Synthesis of 3-Hydroxy-1,5-naphthyridine-4-carbaldehyde

Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination

Furan-Terminated N-Acyliminium Ion Initiated Cyclizations in Alkaloid Synthesis

Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6)

Exploratory Process Development of Lorlatinib

Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Continuous Production of Anhydrous tert-Butyl Hydroperoxide in Nonane Using Membrane Pervaporation and Its Application in Flow Oxidation of a γ‑Butyrolactam

A Reliable Multikilogram-Scale Synthesis of 2-Acetamido-5-Vinylpyridine Using Catalytic BINAP in a Modified Heck Reaction

Discovery of Two Clinical Histamine H 3 Receptor Antagonists: trans - N -Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans -3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]- N -(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Streamlined Processes for the Synthesis of a Farnesyl Transferase Inhibitor Drug Candidate

Continuous flow aminolysis under high temperature and pressure

Pyrroles as terminators in cationic cyclizations. The preparation of 5,6,7,8-tetrahydroindolizidines and 6,7,8,9-tetrahydro-5H-pyrrolo[1,2-a]azepines

Novel Synthesis of 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea, an Anti-inflammatory Agent

Process Research and Scale-Up for a β-3 Adrenergic Receptor Agonist

Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

Discovery of Two Clinical Histamine H3 Receptor Antagonists: trans-N-Ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-Fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764)

ChemInform Abstract: A Reliable Multikilogram-Scale Synthesis of 2-Acetamido-5-vinylpyridine Using Catalytic BINAP in a Modified Heck Reaction

A significant new product from the addition of dichlorocarbene to tetraphenylcyclone

PREPARATION OF 4-CHLORO-2-THIOPHENECARBOXYLIC ACID via SELECTIVE BISULFITE SALT ADDITION PROCEDURE

PART I. PYRROLES AS TERMINATORS IN CATIONIC CYCLIZATIONS. THE PREPARATION OF 5,6,7,8-TETRAHYDRO - INDOLIZIDINES AND 6,7,8,9-TETRAHYDRO-(5H)-PYRROLO(1,2A)-AZEPINES. PART II. STUDIES DIRECTED TOWARDS THE SYNTHESIS OF SIMPLE INDOLIZIDINE AND QUINOLIZIDINE ALKALOIDS (FURANS)

AN EXAMPLE OF A 1,4-CARBENE ADDITION

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