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BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models

Molecular cancer therapeutics, 2013-11, Vol.12 (11), p.2319-2330

2013

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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

ChemMedChem, 2016-07, Vol.11 (14), p.1517-1530

2016

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

Cancer research (Chicago, Ill.), 2004-10, Vol.64 (19), p.7099-7109

2004

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Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

Cancer research (Chicago, Ill.), 2005-05, Vol.65 (9), p.3781-3787

2005

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Syk tyrosine kinase required for mouse viability and B-cell development

Nature (London), 1995-11, Vol.378 (6554), p.303-306

1995

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Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics

Molecular cancer therapeutics, 2006-06, Vol.5 (6), p.1571-1576

2006

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Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development

Cancer research (Chicago, Ill.), 2002-05, Vol.62 (9), p.2516-2521

2002

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The Src family of tyrosine protein kinases in hemopoietic signal transduction

The FASEB journal, 1992-12, Vol.6 (15), p.3403-3409

1992

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Temporal Differences in the Activation of Three Classes of Non- Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen Receptor Surface Engagement

Proceedings of the National Academy of Sciences - PNAS, 1994-09, Vol.91 (20), p.9524-9528

1994

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Syk tyrosine kinase required for mouse viability and B-cell development

Nature (London), 1995-11, Vol.378 (6554), p.303-303

1995

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Abstract 4125: Identification of candidate predictive biomarkers for the cdc7 kinase inhibitor BMS-863233/XL413

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.4125-4125

2011

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Abstract 4476: BAY 80-6946, a highly selective and potent pan class I PI3K inhibitor induces tumor apoptosis in vitro and tumor regression in vivo in a sub-set of tumor models

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4476-4476

2010

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Physical and Functional Interactions between Lyn and p34 Kinases in Irradiated Human B-cell Precursors

The Journal of biological chemistry, 1996-03, Vol.271 (11), p.6389-6397

1996

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Reconstitution of the B Cell Antigen Receptor Signaling Components in COS Cells ()

The Journal of biological chemistry, 1995-11, Vol.270 (45), p.27072-27078

1995

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Abstract C18: Assessment of Gli1 expression during skin regeneration in mouse models and normal healthy volunteers

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.C18-C18

2009

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Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

The Journal of biological chemistry, 1995-05, Vol.270 (19), p.11590-11594

1995

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Murine pregnancy decidua produces a unique immunosuppressive molecule related to transforming growth factor beta-2

The Journal of immunology (1950), 1990-04, Vol.144 (8), p.3008-3014

1990

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The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

The EMBO journal, 1996-11, Vol.15 (22), p.6251-6261

1996

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Disruption of Epithelial γ δ T Cell Repertoires by Mutation of the Syk Tyrosine Kinase

Proceedings of the National Academy of Sciences - PNAS, 1996-09, Vol.93 (18), p.9704-9709

1996

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Abstract B192: Preclinical characterization of BMS-833923 (XL139), a hedgehog (HH) pathway inhibitor in early clinical development

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.B192-B192

2009

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Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.24442-24448

1993

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Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement

The Journal of biological chemistry, 1994-09, Vol.269 (38), p.23642-23647

1994

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Molecular Cloning of Rodent p72

The Journal of biological chemistry, 1995-05, Vol.270 (21), p.12659

1995

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Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell FcRI Engagement

The Journal of biological chemistry, 1995-10, Vol.270 (40), p.23362

1995

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Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell Fc∊RI Engagement (∗)

The Journal of biological chemistry, 1995-10, Vol.270 (40), p.23362-23365

1995

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BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models

Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

Syk tyrosine kinase required for mouse viability and B-cell development

Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics

Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development

The Src family of tyrosine protein kinases in hemopoietic signal transduction

Temporal Differences in the Activation of Three Classes of Non- Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen Receptor Surface Engagement

Syk tyrosine kinase required for mouse viability and B-cell development

Abstract 4125: Identification of candidate predictive biomarkers for the cdc7 kinase inhibitor BMS-863233/XL413

Abstract 4476: BAY 80-6946, a highly selective and potent pan class I PI3K inhibitor induces tumor apoptosis in vitro and tumor regression in vivo in a sub-set of tumor models

Physical and Functional Interactions between Lyn and p34 Kinases in Irradiated Human B-cell Precursors

Reconstitution of the B Cell Antigen Receptor Signaling Components in COS Cells ()

Abstract C18: Assessment of Gli1 expression during skin regeneration in mouse models and normal healthy volunteers

Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

Murine pregnancy decidua produces a unique immunosuppressive molecule related to transforming growth factor beta-2

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

Disruption of Epithelial γ δ T Cell Repertoires by Mutation of the Syk Tyrosine Kinase

Abstract B192: Preclinical characterization of BMS-833923 (XL139), a hedgehog (HH) pathway inhibitor in early clinical development

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement

Molecular Cloning of Rodent p72

Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell FcRI Engagement

Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell Fc∊RI Engagement (∗)

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