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Updating and further expanding GSK's solvent sustainability guide

Green chemistry : an international journal and green chemistry resource : GC, 2016-01, Vol.18 (13), p.3879-3890

2016

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Development of GSK's reagent guides ― embedding sustainability into reagent selection

Green chemistry : an international journal and green chemistry resource : GC, 2013-01, Vol.15 (6), p.1542-1549

2013

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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.360-364

2009

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Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines

Journal of organic chemistry, 2008-12, Vol.73 (23), p.9511-9514

2008

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Development of GSK's acid and base selection guides

Green chemistry : an international journal and green chemistry resource : GC, 2015-02, Vol.17 (2), p.945-949

2015

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Preparation of 5-Substituted 3-Aminofuran-2-carboxylate Esters

Organic letters, 2000-07, Vol.2 (14), p.2061-2063

2000

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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.469-473

2009

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Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.373-377

2009

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Discovery of a new class of p38 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (18), p.2047-2050

2000

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Updating and further expanding GSK's solvent sustainability guideElectronic supplementary information (ESI) available. See DOI: 10.1039/c6gc00611f

2016-06

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p38 Kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (1), p.9-12

2001

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Development of GSK's acid and base selection guidesElectronic supplementary information (ESI) available. See DOI: 10.1039/c4gc01481b

2015-02

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4965-4968

2006

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.3053-3057

2005

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Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1 H -pyrrolo[2,3- d ]pyrimidines

Journal of organic chemistry, 2008-12, Vol.73 (23), p.9511-9514

2008

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Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.373-377

2009

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Optimization of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.360-364

2009

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Discovery of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.469-473

2009

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Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor

Bioorganic & medicinal chemistry letters, 2002-06, Vol.12 (12), p.1559-1562

2002

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4965

2006

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 2. SAR

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (12), p.3053-3057

2005

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Vinylboranes as trans-dihydroxyethylene equivalents for diels-alder reactions

Tetrahedron letters, 1994, Vol.35 (4), p.509-512

1994

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Optimization of 4,6-bis-anilmo-1H-pyrrolo[2,3-d]pyrimidme IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (2), p.360-364

2009

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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

ChemMedChem, 2016-07, Vol.11 (14), p.1517-1530

2016

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of 17β-hydroxysteroid dehydrogenase II. Part 1: Synthetic approach

Tetrahedron letters, 2005-02, Vol.46 (9), p.1525-1528

2005

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Updating and further expanding GSK's solvent sustainability guide

Development of GSK's reagent guides ― embedding sustainability into reagent selection

Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines

Development of GSK's acid and base selection guides

Preparation of 5-Substituted 3-Aminofuran-2-carboxylate Esters

Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase

Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway

Discovery of a new class of p38 kinase inhibitors

Updating and further expanding GSK's solvent sustainability guideElectronic supplementary information (ESI) available. See DOI: 10.1039/c6gc00611f

p38 Kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas

Development of GSK's acid and base selection guidesElectronic supplementary information (ESI) available. See DOI: 10.1039/c4gc01481b

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR

Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1 H -pyrrolo[2,3- d ]pyrimidines

Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway

Optimization of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Discovery of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase

Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate

4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 2. SAR

Vinylboranes as trans-dihydroxyethylene equivalents for diels-alder reactions

Optimization of 4,6-bis-anilmo-1H-pyrrolo[2,3-d]pyrimidme IGF-1R tyrosine kinase inhibitors towards JNK selectivity

Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

4,5-Disubstituted cis-pyrrolidinones as inhibitors of 17β-hydroxysteroid dehydrogenase II. Part 1: Synthetic approach

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