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Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic

Naunyn-Schmiedeberg's archives of pharmacology, 2016-10, Vol.389 (10), p.1133-1137

2016

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A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Journal of biomolecular screening, 2016-01, Vol.21 (1), p.1-11

2016

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A history of the role of the hERG channel in cardiac risk assessment

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.13-22

2013

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Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K+ Channel. A Model for Bad Behavior

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2017-2022

2003

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Pentamidine-induced long QT syndrome and block of hERG trafficking

The Journal of pharmacology and experimental therapeutics, 2005-01, Vol.312 (1), p.316-323

2005

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A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

European journal of pharmacology, 2002-08, Vol.450 (1), p.37-41

2002

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Interactions of a Series of Fluoroquinolone Antibacterial Drugs with the Human Cardiac K+ Channel HERG

Molecular pharmacology, 2001-01, Vol.59 (1), p.122-126

2001

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Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel

Molecular pharmacology, 2005-03, Vol.67 (3), p.827-836

2005

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Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (10), p.1829-1835

2003

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Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs

Anesthesiology (Philadelphia), 2006-05, Vol.104 (5), p.1015-1022

2006

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ILSI-HESI cardiovascular safety subcommittee initiative: Evaluation of three non-clinical models of QT prolongation

Journal of pharmacological and toxicological methods, 2006-09, Vol.54 (2), p.116-129

2006

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A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG

FEBS letters, 1997-11, Vol.417 (1), p.28-32

1997

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Voltage-Gated Ion Channels as Drug Targets

1. Aufl., 2006

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On Becoming a Pharmacologist: Channeling David Triggle

Biochemical pharmacology, 2015-11, Vol.98 (2), p.292-298

2015

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The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG

The Journal of pharmacology and experimental therapeutics, 1998-08, Vol.286 (2), p.788

1998

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Cardiac ion channel effects of tolterodine

The Journal of pharmacology and experimental therapeutics, 2004-03, Vol.308 (3), p.935-940

2004

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Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG

The Journal of pharmacology and experimental therapeutics, 2001-10, Vol.299 (1), p.290

2001

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High affinity blockade of the HERG cardiac K + channel by the neuroleptic pimozide

European journal of pharmacology, 2000-03, Vol.392 (3), p.137-140

2000

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Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.446-451

2018

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A Festschrift in honor of David J. Triggle

Biochemical pharmacology, 2015-11, Vol.98 (2), p.267-268

2015

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L-type Ca2+ channel responses to bay k 8644 in stem cell-derived cardiomyocytes are unusually dependent on holding potential and charge carrier

Assay and drug development technologies, 2014-08, Vol.12 (6), p.352

2014

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Observations on conducting whole‐cell patch clamping of the hERG cardiac K+ channel in pure human serum

Journal of applied toxicology, 2017-04, Vol.37 (4), p.445-453

2017

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Observations on conducting whole-cell patch clamping of the hERG cardiac K super(+) channel in pure human serum

Journal of applied toxicology, 2017-04, Vol.37 (4), p.445-453

2017

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Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes

The Journal of pharmacology and experimental therapeutics, 2012-05, Vol.341 (2), p.510

2012

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In vitro electrocardiographic and cardiac ion channel effects of (-)-epigallocatechin-3-gallate, the main catechin of green tea

The Journal of pharmacology and experimental therapeutics, 2010-08, Vol.334 (2), p.619-626

2010

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Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

A history of the role of the hERG channel in cardiac risk assessment

Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K+ Channel. A Model for Bad Behavior

Pentamidine-induced long QT syndrome and block of hERG trafficking

A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

Interactions of a Series of Fluoroquinolone Antibacterial Drugs with the Human Cardiac K+ Channel HERG

Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs

ILSI-HESI cardiovascular safety subcommittee initiative: Evaluation of three non-clinical models of QT prolongation

A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG

Voltage-Gated Ion Channels as Drug Targets

On Becoming a Pharmacologist: Channeling David Triggle

The antipsychotic agent sertindole is a high affinity antagonist of the human cardiac potassium channel HERG

Cardiac ion channel effects of tolterodine

Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG

High affinity blockade of the HERG cardiac K + channel by the neuroleptic pimozide

Molecular determinants of loperamide and N-desmethyl loperamide binding in the hERG cardiac K+ channel

A Festschrift in honor of David J. Triggle

L-type Ca2+ channel responses to bay k 8644 in stem cell-derived cardiomyocytes are unusually dependent on holding potential and charge carrier

Observations on conducting whole‐cell patch clamping of the hERG cardiac K+ channel in pure human serum

Observations on conducting whole-cell patch clamping of the hERG cardiac K super(+) channel in pure human serum

Ca²⁺ channel activators reveal differential L-type Ca²⁺ channel pharmacology between native and stem cell-derived cardiomyocytes

In vitro electrocardiographic and cardiac ion channel effects of (-)-epigallocatechin-3-gallate, the main catechin of green tea

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