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Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models

Annual review of medicine, 2017-01, Vol.68, p.51

2017

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The role of LTBPs in TGF beta signaling

Developmental dynamics, 2022-01, Vol.251 (1), p.95-104

2022

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The Multiple Functions of Fibrillin-1 Microfibrils in Organismal Physiology

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1892

2022

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Biogenesis and function of fibrillin assemblies

Cell and tissue research, 2010-01, Vol.339 (1), p.71-82

2010

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Tendon Functional Extracellular Matrix

Journal of orthopaedic research, 2015-06, Vol.33 (6), p.793-799

2015

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Marfan syndrome: from molecular pathogenesis to clinical treatment

Current opinion in genetics & development, 2007-06, Vol.17 (3), p.252-258

2007

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Cell Type-Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease-Brief Report

Arteriosclerosis, thrombosis, and vascular biology, 2018-03, Vol.38 (3), p.588

2018

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Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Science (American Association for the Advancement of Science), 2006-04, Vol.312 (5770), p.117-121

2006

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Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events

Journal of cellular physiology, 2007-11, Vol.213 (2), p.326-330

2007

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Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (45), p.14012-14017

2015

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Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection

JCI insight, 2018-03, Vol.3 (5)

2018

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Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses

Journal of comparative neurology (1911), 2010-01, Vol.518 (2), p.229-253

2010

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Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome

Annals of biomedical engineering, 2016-10, Vol.44 (10), p.2994-3006

2016

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Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice

PLoS genetics, 2015-06, Vol.11 (6), p.e1005340-e1005340

2015

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p38 MAPK Is an Early Determinant of Promiscuous Smad2/3 Signaling in the Aortas of Fibrillin-1 (Fbn1)-null Mice

The Journal of biological chemistry, 2009-02, Vol.284 (9), p.5630-5636

2009

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Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues

PLoS genetics, 2014-01, Vol.10 (1), p.e1004121-e1004121

2014

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Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells

JCI insight, 2023-05, Vol.8 (10)

2023

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Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome

Journal of vascular surgery, 2008, Vol.47 (1), p.166-172

2008

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Fibrillins 1 and 2 Perform Partially Overlapping Functions during Aortic Development

The Journal of biological chemistry, 2006-03, Vol.281 (12), p.8016-8023

2006

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Recent progress towards a molecular understanding of Marfan syndrome

American journal of medical genetics. Part C, Seminars in medical genetics, 2005-11, Vol.139C (1), p.4-9

2005

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Report of the National Heart, Lung, and Blood Institute and National Marfan Foundation Working Group on Research in Marfan Syndrome and Related Disorders

Circulation, 2008-08, Vol.118 (7), p.785-791

2008

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Synergistic Cooperation between Sp1 and Smad3/Smad4 Mediates Transforming Growth Factor β1 Stimulation of α2(I)-Collagen (COL1A2) Transcription

The Journal of biological chemistry, 2000-12, Vol.275 (50), p.39237-39245

2000

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Discrete contributions of elastic fiber components to arterial development and mechanical compliance

Arteriosclerosis, thrombosis, and vascular biology, 2009-12, Vol.29 (12), p.2083

2009

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Fibrillin assemblies: extracellular determinants of tissue formation and fibrosis

Fibrogenesis & tissue repair, 2010-12, Vol.3 (1), p.24-24, Article 24

2010

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Transcriptional regulation of the human α2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases

Matrix biology, 2006-08, Vol.25 (6), p.365-372

2006

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Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models

The role of LTBPs in TGF beta signaling

The Multiple Functions of Fibrillin-1 Microfibrils in Organismal Physiology

Biogenesis and function of fibrillin assemblies

Tendon Functional Extracellular Matrix

Marfan syndrome: from molecular pathogenesis to clinical treatment

Cell Type-Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease-Brief Report

Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events

Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome

Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection

Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses

Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome

Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice

p38 MAPK Is an Early Determinant of Promiscuous Smad2/3 Signaling in the Aortas of Fibrillin-1 (Fbn1)-null Mice

Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues

Dissecting aortic aneurysm in Marfan syndrome is associated with losartan-sensitive transcriptomic modulation of aortic cells

Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome

Fibrillins 1 and 2 Perform Partially Overlapping Functions during Aortic Development

Recent progress towards a molecular understanding of Marfan syndrome

Report of the National Heart, Lung, and Blood Institute and National Marfan Foundation Working Group on Research in Marfan Syndrome and Related Disorders

Synergistic Cooperation between Sp1 and Smad3/Smad4 Mediates Transforming Growth Factor β1 Stimulation of α2(I)-Collagen (COL1A2) Transcription

Discrete contributions of elastic fiber components to arterial development and mechanical compliance

Fibrillin assemblies: extracellular determinants of tissue formation and fibrosis

Transcriptional regulation of the human α2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases

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