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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

Nature medicine, 2017-04, Vol.23 (4), p.461-471

2017

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Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration

PLoS computational biology, 2019-10, Vol.15 (10), p.e1007467-e1007467

2019

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The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (8), p.4053-4060

2020

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ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing

PLoS genetics, 2014-11, Vol.10 (11), p.e1004782

2014

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Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes

PLoS genetics, 2016-06, Vol.12 (6), p.e1006081-e1006081

2016

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Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

Cell, 2016-03, Vol.165 (1), p.234-246

2016

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Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Nature microbiology, 2017-02, Vol.2, p.16274

2017

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Defining principles of combination drug mechanisms of action

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (2), p.E170-E179

2013

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Addressing genetic tumor heterogeneity through computationally predictive combination therapy

Cancer discovery, 2014-02, Vol.4 (2), p.166-174

2014

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Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design

Cell reports (Cambridge), 2020-03, Vol.30 (12), p.3951-3963.e4

2020

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A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments

Nature communications, 2022-02, Vol.13 (1), p.625-625, Article 625

2022

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Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts

BMC medicine, 2021-07, Vol.19 (1), p.162-162, Article 162

2021

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A mammalian functional-genetic approach to characterizing cancer therapeutics

Nature chemical biology, 2011-02, Vol.7 (2), p.92

2011

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A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

Genes & development, 2015-03, Vol.29 (5), p.483-488

2015

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Refined Quantification of Infection Bottlenecks and Pathogen Dissemination with STAMPR

mSystems, 2021-08, Vol.6 (4), p.e0088721-e0088721

2021

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A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy

Genome medicine, 2021-10, Vol.13 (1), p.167-167, Article 167

2021

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Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors

iScience, 2021-11, Vol.24 (11), p.103343-103343, Article 103343

2021

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Materials-driven approaches to understand extrinsic drug resistance in cancer

Soft matter, 2022-05, Vol.18 (18), p.3465-3472

2022

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High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data

Nucleic acids research, 2013-10, Vol.41 (19), p.9033

2013

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Understanding resistance to combination chemotherapy

Drug resistance updates, 2012-10, Vol.15 (5), p.249-257

2012

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Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers

Clinical cancer research, 2022-04, Vol.28 (7), p.1268-1276

2022

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Deciphering the Mechanistic Basis for Perfluoroalkyl‐Protein Interactions

Chembiochem : a European journal of chemical biology, 2023-07, Vol.24 (13), p.e202300159-n/a

2023

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Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes

Journal of biological inorganic chemistry, 2021-08, Vol.26 (5), p.535-549

2021

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Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death

Molecular cancer therapeutics, 2009-08, Vol.8 (8), p.2183-2192

2009

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Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias

Clinical cancer research, 2018-11, Vol.24 (21), p.5321-5334

2018

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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning

ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing

Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Defining principles of combination drug mechanisms of action

Addressing genetic tumor heterogeneity through computationally predictive combination therapy

Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments

Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts

A mammalian functional-genetic approach to characterizing cancer therapeutics

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

Refined Quantification of Infection Bottlenecks and Pathogen Dissemination with STAMPR

A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy

Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors

Materials-driven approaches to understand extrinsic drug resistance in cancer

High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data

Understanding resistance to combination chemotherapy

Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers

Deciphering the Mechanistic Basis for Perfluoroalkyl‐Protein Interactions

Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes

Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death

Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias

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