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Phosphodiesterases in neurodegenerative disorders

IUBMB life, 2012-12, Vol.64 (12), p.965-970

2012

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Phosphodiesterase Inhibitors Enhance Object Memory Independent of Cerebral Blood Flow and Glucose Utilization in Rats

Neuropsychopharmacology (New York, N.Y.), 2009-07, Vol.34 (8), p.1914-1925

2009

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DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation

Cellular and molecular life sciences : CMLS, 2021-10, Vol.78 (19-20), p.6631-6644

2021

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The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

Behavioural brain research, 2016-04, Vol.303, p.26-33

2016

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A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer's disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial

Trials, 2024-03, Vol.25 (1), p.162-162, Article 162

2024

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Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?

Pharmacological research, 2023-11, Vol.197, p.106970-106970, Article 106970

2023

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Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation

Scientific reports, 2023-11, Vol.13 (1), p.20384-20384, Article 20384

2023

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From OPC to Oligodendrocyte: An Epigenetic Journey

Cells (Basel, Switzerland), 2019-10, Vol.8 (10), p.1236

2019

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Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice

Hypertension research, 2018-10, Vol.41 (10), p.817-827

2018

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Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7537

2020

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Possible Overlapping Time Frames of Acquisition and Consolidation Phases in Object Memory Processes: A Pharmacological Approach

Learning & memory (Cold Spring Harbor, N.Y.), 2016-01, Vol.23 (1), p.29-37

2016

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Object recognition testing: Methodological considerations on exploration and discrimination measures

Behavioural brain research, 2012-07, Vol.232 (2), p.335-347

2012

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Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence

PloS one, 2011-09, Vol.6 (9), p.e24003

2011

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Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Neuropharmacology, 2018-08, Vol.138, p.360-370

2018

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Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

Psychopharmacology, 2009-01, Vol.202 (1-3), p.419-443

2009

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Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition

Neurotherapeutics, 2024-07, Vol.21 (4), p.e00372, Article e00372

2024

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Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease

Scientific reports, 2017-04, Vol.7 (1), p.46320, Article 46320

2017

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Pharmacological depletion of microglia and perivascular macrophages prevents vascular Cognitive Impairment in Ang II-induced Hypertension

Theranostics, 2020-01, Vol.10 (21), p.9512-9527

2020

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Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

Frontiers in immunology, 2019-07, Vol.10, p.1727-1727

2019

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Object recognition testing: Rodent species, strains, housing conditions, and estrous cycle

Behavioural brain research, 2012-07, Vol.232 (2), p.323-334

2012

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Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801

Behavioural brain research, 2013-01, Vol.236 (1), p.16-22

2013

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The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

Scientific reports, 2022-03, Vol.12 (1), p.3589-15, Article 3589

2022

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Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking

Journal of psychopharmacology (Oxford), 2020-01, Vol.34 (1), p.103-114

2020

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Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease[S]

Journal of lipid research, 2020-06, Vol.61 (6), p.830-839

2020

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A perspective on causality assessment in epigenetic research on neurodegenerative disorders

Neural regeneration research, 2023-02, Vol.18 (2), p.331-332

2023

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Phosphodiesterases in neurodegenerative disorders

Phosphodiesterase Inhibitors Enhance Object Memory Independent of Cerebral Blood Flow and Glucose Utilization in Rats

DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation

The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses

A proof of concept phase II study with the PDE-4 inhibitor roflumilast in patients with mild cognitive impairment or mild Alzheimer's disease dementia (ROMEMA): study protocol of a double-blind, randomized, placebo-controlled, between-subjects trial

Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?

Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation

From OPC to Oligodendrocyte: An Epigenetic Journey

Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice

Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation

Possible Overlapping Time Frames of Acquisition and Consolidation Phases in Object Memory Processes: A Pharmacological Approach

Object recognition testing: Methodological considerations on exploration and discrimination measures

Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence

Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease

Pharmacological depletion of microglia and perivascular macrophages prevents vascular Cognitive Impairment in Ang II-induced Hypertension

Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

Object recognition testing: Rodent species, strains, housing conditions, and estrous cycle

Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801

The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms

Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking

Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease[S]

A perspective on causality assessment in epigenetic research on neurodegenerative disorders

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