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Building predictive models for mechanism-of-action classification from phenotypic assay data sets

Journal of biomolecular screening, 2013-12, Vol.18 (10), p.1260-1269

2013

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Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects

International journal of molecular sciences, 2015-01, Vol.16 (1), p.1008-1029

2015

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Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation

PloS one, 2013-03, Vol.8 (3), p.e58966-e58966

2013

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Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

The Journal of biological chemistry, 2005-05, Vol.280 (20), p.19867-19874

2005

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Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors

The Journal of biological chemistry, 2002-01, Vol.277 (1), p.295-302

2002

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Potent Triazolothione Inhibitor of Heat-Shock Protein-90

Chemical biology & drug design, 2009-07, Vol.74 (1), p.43-50

2009

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Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

Frontiers in immunology, 2014, Vol.5, p.233

2014

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Allosteric Inhibitors of Inducible Nitric Oxide Synthase Dimerization Discovered via Combinatorial Chemistry

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (4), p.1506-1511

2000

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX- 517

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3819-3825

2007

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3814-3818

2007

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A Novel High-Throughput Screening Format to Identify Inhibitors of Secreted Acid Sphingomyelinase

Journal of biomolecular screening, 2005-04, Vol.10 (3), p.225-234

2005

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Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle

Journal of medicinal chemistry, 1995-06, Vol.38 (12), p.2119-2129

1995

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Yeast thioltransferase—The active site cysteines display differential reactivity

Archives of biochemistry and biophysics, 1990-10, Vol.282 (1), p.110-115

1990

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Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

Experimental biology and medicine (Maywood, N.J.), 1990-11, Vol.195 (2), p.168-171

1990

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Chronic ethanol increases liver plasma membrane fluidity

Biochemistry (Easton), 1985-06, Vol.24 (13), p.3114-3120

1985

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Evidence of Glycosylated Sites on the Endothelin-1 Receptor in Swiss 3T3 Cells

Journal of cardiovascular pharmacology, 1991, Vol.17 Suppl 7, p.S134-136

1991

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High capacity screening of pooled compounds: Identification of the active compound without re-assay of pool members

Drug development research, 1996-02, Vol.37 (2), p.80-85

1996

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Effect of chronic ethanol administration on enzyme and lipid properties of liver plasma membranes in long and short sleep mice

Hepatology (Baltimore, Md.), 1985-07, Vol.5 (4), p.531-537

1985

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High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28]echistatin

Gene, 1989-06, Vol.79 (1), p.159-166

1989

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Ethanol treatment increases triacylglycerol and cholesteryl ester content of cultured hepatoma cells

Journal of lipid research, 1983-08, Vol.24 (8), p.1030-1038

1983

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Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees

AIDS research and human retroviruses, 1990-11, Vol.6 (11), p.1247-1250

1990

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Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase

Biochimica et biophysica acta, 1980-04, Vol.618 (1), p.129-142

1980

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Hypertriacylglycerolemia in the chick: Effect of estrogen on hepatic microsomal enzymes of triacylglycerol and phospholipid synthesis

Metabolism, clinical and experimental, 1977-10, Vol.26 (10), p.1123-1130

1977

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Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Nature biotechnology, 2014-06, Vol.32 (6), p.583-591

2014

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Building predictive models for mechanism-of-action classification from phenotypic assay data sets

Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects

Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation

Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors

Potent Triazolothione Inhibitor of Heat-Shock Protein-90

Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

Allosteric Inhibitors of Inducible Nitric Oxide Synthase Dimerization Discovered via Combinatorial Chemistry

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX- 517

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Characterization of Novel PI3KÎ´ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

A Novel High-Throughput Screening Format to Identify Inhibitors of Secreted Acid Sphingomyelinase

Hydroxamic Acids as Potent Inhibitors of Endothelin-Converting Enzyme from Human Bronchiolar Smooth Muscle

Yeast thioltransferase—The active site cysteines display differential reactivity

Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

Chronic ethanol increases liver plasma membrane fluidity

Evidence of Glycosylated Sites on the Endothelin-1 Receptor in Swiss 3T3 Cells

High capacity screening of pooled compounds: Identification of the active compound without re-assay of pool members

Effect of chronic ethanol administration on enzyme and lipid properties of liver plasma membranes in long and short sleep mice

High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28]echistatin

Ethanol treatment increases triacylglycerol and cholesteryl ester content of cultured hepatoma cells

Yeast-expressed p55 precursor core protein of human immunodeficiency virus type 1 does not elicit protective immunity in chimpanzees

Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase

Hypertriacylglycerolemia in the chick: Effect of estrogen on hepatic microsomal enzymes of triacylglycerol and phospholipid synthesis

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

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