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Clinical Trial Simulation: A Review

Clinical pharmacology and therapeutics, 2010-08, Vol.88 (2), p.166-182

2010

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Population pharmacokinetic characterization of BAY 81‐8973, a full‐length recombinant factor VIII: lessons learned ‒ importance of including samples with factor VIII levels below the quantitation limit

Haemophilia : the official journal of the World Federation of Hemophilia, 2017-07, Vol.23 (4), p.528-537

2017

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Response to "Validation and Assessment of Predictive Performance in Simulation Models of Clinical Trials"

Clinical pharmacology and therapeutics, 2011-04, Vol.89 (4), p.488-488

2011

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Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling

British journal of pharmacology, 2014-11, Vol.171 (22), p.5076-5092

2014

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Estimation of Systemic Toxicity of Acrylamide by Integration of in Vitro Toxicity Data with Kinetic Simulations

Toxicology and applied pharmacology, 1999-08, Vol.158 (3), p.261-268

1999

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PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats

British journal of pharmacology, 2013-08, Vol.169 (7), p.1510-1524

2013

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Physiologically Based Pharmacokinetic Modeling of Glycyrrhizic Acid, a Compound Subject to Presystemic Metabolism and Enterohepatic Cycling

Toxicology and applied pharmacology, 2000-02, Vol.162 (3), p.177-188

2000

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A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat

Journal of pharmacokinetics and pharmacodynamics, 2011-12, Vol.38 (6), p.697-711

2011

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Nonlinear Mixed Effects Modeling of the Diurnal Blood Pressure Profile in a Multiracial Population

American journal of hypertension, 2013-09, Vol.26 (9), p.1103-1113

2013

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Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

DRUG METABOLISM AND PHARMACOKINETICS, 2009-01, Vol.24 (1), p.3-15

2009

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658PExploration of efficacious alternative regorafenib regimens to manage hand-foot-skin-reaction (HFSR)

Annals of oncology, 2019-10, Vol.30 (Supplement_5)

2019

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890PAssessing the clinical relevance of drug-drug interactions (DDI) with darolutamide (DARO)

Annals of oncology, 2019-10, Vol.30 (Supplement_5)

2019

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PK/PD modelling of reversal of neuromuscular blockade by a chemically optimised cyclodextrin

Clinical pharmacology and therapeutics, 2004-02, Vol.75 (2), p.P80-P80

2004

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Absorption model based on transport physics theory applied to paracetamol

Clinical pharmacology and therapeutics, 2004-02, Vol.75 (2), p.P80-P80

2004

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Population Pharmacokinetic Analysis for Simultaneous Determination of B max and K D In Vivo by Positron Emission Tomography

Molecular imaging and biology, 2005-11, Vol.7 (6), p.411-421

2005

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Alterations in GABAA receptor kinetics in epileptic rats studied in vivo using positron emission tomography

NeuroImage (Orlando, Fla.), 2006, Vol.31, p.T145-T145

2006

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Population Pharmacokinetic Analysis for Simultaneous Determination of B sub(max) and K sub(D) In Vivo by Positron Emission Tomography

Molecular imaging and biology, 2005-11, Vol.7 (6), p.411-421

2005

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Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe

Preventive veterinary medicine, 2020-09, Vol.182, p.105103, Article 105103

2020

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Transport of the 2017 Canadian wildfire plume to the tropics via the Asian monsoon circulation

Atmospheric chemistry and physics, 2019-11, Vol.19 (21), p.13547-13567

2019

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Response of stratospheric water vapor and ozone to the unusual timing of El Niño and the QBO disruption in 2015–2016

Atmospheric chemistry and physics, 2018-09, Vol.18 (17), p.13055-13073

2018

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The evolution and dynamics of the Hunga Tonga–Hunga Ha'apai sulfate aerosol plume in the stratosphere

Atmospheric chemistry and physics, 2022-11, Vol.22 (22), p.14957-14970

2022

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Impact of uncertainties in atmospheric mixing on simulated UTLS composition and related radiative effects

Journal of Geophysical Research: Atmospheres, 2012-08, Vol.117 (D16), p.n/a

2012

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How robust are stratospheric age of air trends from different reanalyses?

Atmospheric chemistry and physics, 2019-05, Vol.19 (9), p.6085-6105

2019

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Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

Trends in pharmacological sciences (Regular ed.), 2008-04, Vol.29 (4), p.186-191

2008

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Communication Competence, Social Support, and Depression Among College Students: A Model of Facebook and Face-to-Face Support Network Influence

Journal of health communication, 2013-01, Vol.18 (1), p.41-57

2013

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Clinical Trial Simulation: A Review

Population pharmacokinetic characterization of BAY 81‐8973, a full‐length recombinant factor VIII: lessons learned ‒ importance of including samples with factor VIII levels below the quantitation limit

Response to "Validation and Assessment of Predictive Performance in Simulation Models of Clinical Trials"

Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling

Estimation of Systemic Toxicity of Acrylamide by Integration of in Vitro Toxicity Data with Kinetic Simulations

PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats

Physiologically Based Pharmacokinetic Modeling of Glycyrrhizic Acid, a Compound Subject to Presystemic Metabolism and Enterohepatic Cycling

A hidden Markov model to assess drug-induced sleep fragmentation in the telemetered rat

Nonlinear Mixed Effects Modeling of the Diurnal Blood Pressure Profile in a Multiracial Population

Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

658PExploration of efficacious alternative regorafenib regimens to manage hand-foot-skin-reaction (HFSR)

890PAssessing the clinical relevance of drug-drug interactions (DDI) with darolutamide (DARO)

PK/PD modelling of reversal of neuromuscular blockade by a chemically optimised cyclodextrin

Absorption model based on transport physics theory applied to paracetamol

Population Pharmacokinetic Analysis for Simultaneous Determination of B max and K D In Vivo by Positron Emission Tomography

Alterations in GABAA receptor kinetics in epileptic rats studied in vivo using positron emission tomography

Population Pharmacokinetic Analysis for Simultaneous Determination of B sub(max) and K sub(D) In Vivo by Positron Emission Tomography

Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe

Transport of the 2017 Canadian wildfire plume to the tropics via the Asian monsoon circulation

Response of stratospheric water vapor and ozone to the unusual timing of El Niño and the QBO disruption in 2015–2016

The evolution and dynamics of the Hunga Tonga–Hunga Ha'apai sulfate aerosol plume in the stratosphere

Impact of uncertainties in atmospheric mixing on simulated UTLS composition and related radiative effects

How robust are stratospheric age of air trends from different reanalyses?

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

Communication Competence, Social Support, and Depression Among College Students: A Model of Facebook and Face-to-Face Support Network Influence

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