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Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1

ChemMedChem, 2007-07, Vol.2 (7), p.995-999

2007

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Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (21), p.4812-4819

2015

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Asymmetric addition reactions of Grignard reagents to chiral 2-trifluoromethyl tert-butyl (Ellman) sulfinimine–ethanol adducts

Tetrahedron letters, 2006-04, Vol.47 (14), p.2377-2381

2006

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Martinelline and Martinellic Acid, Novel G-Protein Linked Receptor Antagonists from the Tropical Plant Martinella iquitosensis (Bignoniaceae)

Journal of the American Chemical Society, 1995-06, Vol.117 (25), p.6682-6685

1995

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Mechanism of the solution oxidation of rofecoxib under alkaline conditions

Pharmaceutical research, 2005-10, Vol.22 (10), p.1716-1726

2005

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Transglutaminase Inhibition by 2-[(2-Oxopropyl)thio]imidazolium Derivatives: Mechanism of Factor XIIIa Inactivation

Biochemistry (Easton), 1994-08, Vol.33 (33), p.10109-10119

1994

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Solution structure of the cytoplasmic domain of phospholamban: phosphorylation leads to a local perturbation in secondary structure

Biochemistry (Easton), 1995-06, Vol.34 (23), p.7603-7613

1995

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Identification and quantitation of extractables from cellulose acetate butyrate (CAB) and estimation of their in vivo exposure levels

Journal of pharmaceutical and biomedical analysis, 2004-06, Vol.35 (4), p.779-788

2004

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Antibacterial Activity of Lonchocarpol A

Journal of natural products (Washington, D.C.), 1998-05, Vol.61 (5), p.640-642

1998

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Total synthesis of nonpeptidal cholecystokinin antagonists from Aspergillus alliaceus

Journal of organic chemistry, 1987-04, Vol.52 (8), p.1644-1646

1987

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Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1437

2003

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Complestatin to chloropeptin I via a quantitative acid catalyzed rearrangement. Absolute stereochemical determination of complestatin

Tetrahedron letters, 1998-04, Vol.39 (16), p.2247-2248

1998

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Proton NMR assignments and secondary structure of the snake venom protein echistatin

Biochemistry (Easton), 1991-12, Vol.30 (50), p.11625-11636

1991

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High Fatty Acid Content in Rabbit Serum Is Responsible for the Differentiation of Osteoblasts Into Adipocyte‐like Cells

Journal of bone and mineral research, 1998-01, Vol.13 (1), p.96-106

1998

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Fluoride-induced formation and ring opening of cyclic sulfamates from hydroxy triflamides. Synthetic and mechanistic studies

Journal of the American Chemical Society, 1987-12, Vol.109 (25), p.7890-7891

1987

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Infrared spectroscopy of matrix-isolated propadienone

Journal of the American Chemical Society, 1987-10, Vol.109 (22), p.6867-6868

1987

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A novel oxidative degradation pathway of indomethacin under the stressing by hydrogen peroxide

Tetrahedron letters, 2005-05, Vol.46 (20), p.3533-3536

2005

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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3813-3821

1992

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On the Chemistry of the 18-Deoxycytochalasin H, HIV-1 Protease Inhibitor, L-696,474. 2: Novel Ring Annulations

Heterocycles, 1995-03, Vol.41 (3), p.409

1995

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An unusual dimer of 2-mercaptothiophene

Journal of organic chemistry, 1989-06, Vol.54 (13), p.3223-3224

1989

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Characterization of a solid state reaction product from a lyophilized formulation of a cyclic heptapeptide. A novel example of an excipient-induced oxidation

Pharmaceutical research, 1996-12, Vol.13 (12), p.1811-1814

1996

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Iminium ion-mediated cyclizations of 4-aryl-1,4-dihydropyridines. Regio- and stereoselective intermolecular cycloaddition reactions

Journal of organic chemistry, 1989-08, Vol.54 (17), p.4134-4137

1989

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BIOACTIVATION OF THE 3-AMINO-6-CHLOROPYRAZINONE RING IN A THROMBIN INHIBITOR LEADS TO NOVEL DIHYDRO-IMIDAZOLE AND IMIDAZOLIDINE DERIVATIVES: STRUCTURES AND MECHANISM USING 13 C-LABELS, MASS SPECTROMETRY, AND NMR

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1437-1447

2003

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Cover Picture: Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1 (ChemMedChem 7/2007)

ChemMedChem, 2007-07, Vol.2 (7), p.909-909

2007

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Identification of fatty acid methyl ester as naturally occurring transcriptional regulators of the members of the peroxisome proliferator‐activated receptor family

Lipids, 1996-11, Vol.31 (11), p.1115-1124

1996

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Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

Asymmetric addition reactions of Grignard reagents to chiral 2-trifluoromethyl tert-butyl (Ellman) sulfinimine–ethanol adducts

Martinelline and Martinellic Acid, Novel G-Protein Linked Receptor Antagonists from the Tropical Plant Martinella iquitosensis (Bignoniaceae)

Mechanism of the solution oxidation of rofecoxib under alkaline conditions

Transglutaminase Inhibition by 2-[(2-Oxopropyl)thio]imidazolium Derivatives: Mechanism of Factor XIIIa Inactivation

Solution structure of the cytoplasmic domain of phospholamban: phosphorylation leads to a local perturbation in secondary structure

Identification and quantitation of extractables from cellulose acetate butyrate (CAB) and estimation of their in vivo exposure levels

Antibacterial Activity of Lonchocarpol A

Total synthesis of nonpeptidal cholecystokinin antagonists from Aspergillus alliaceus

Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR

Complestatin to chloropeptin I via a quantitative acid catalyzed rearrangement. Absolute stereochemical determination of complestatin

Proton NMR assignments and secondary structure of the snake venom protein echistatin

High Fatty Acid Content in Rabbit Serum Is Responsible for the Differentiation of Osteoblasts Into Adipocyte‐like Cells

Fluoride-induced formation and ring opening of cyclic sulfamates from hydroxy triflamides. Synthetic and mechanistic studies

Infrared spectroscopy of matrix-isolated propadienone

A novel oxidative degradation pathway of indomethacin under the stressing by hydrogen peroxide

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs

On the Chemistry of the 18-Deoxycytochalasin H, HIV-1 Protease Inhibitor, L-696,474. 2: Novel Ring Annulations

An unusual dimer of 2-mercaptothiophene

Characterization of a solid state reaction product from a lyophilized formulation of a cyclic heptapeptide. A novel example of an excipient-induced oxidation

Iminium ion-mediated cyclizations of 4-aryl-1,4-dihydropyridines. Regio- and stereoselective intermolecular cycloaddition reactions

BIOACTIVATION OF THE 3-AMINO-6-CHLOROPYRAZINONE RING IN A THROMBIN INHIBITOR LEADS TO NOVEL DIHYDRO-IMIDAZOLE AND IMIDAZOLIDINE DERIVATIVES: STRUCTURES AND MECHANISM USING 13 C-LABELS, MASS SPECTROMETRY, AND NMR

Cover Picture: Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1 (ChemMedChem 7/2007)

Identification of fatty acid methyl ester as naturally occurring transcriptional regulators of the members of the peroxisome proliferator‐activated receptor family

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