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Development of radioligands for imaging of brain norepinephrine transporters in vivo with positron emission tomography

Current topics in medicinal chemistry, 2007-09, Vol.7 (18), p.1806-1816

2007

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Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers

Molecular psychiatry, 2012-06, Vol.17 (6), p.642-649

2012

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The Inhibitor Ko143 Is Not Specific for ABCG2

The Journal of pharmacology and experimental therapeutics, 2015-09, Vol.354 (3), p.384-393

2015

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Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, ( S,S)-[ 11C]MeNER

Nuclear medicine and biology, 2003-10, Vol.30 (7), p.707-714

2003

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First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B

The Journal of nuclear medicine (1978), 2022-12, Vol.63 (12), p.1919-1924

2022

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Serotonin-1A receptors in major depression quantified using PET: Controversies, confounds, and recommendations

NeuroImage (Orlando, Fla.), 2012-02, Vol.59 (4), p.3243-3251

2012

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The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)

ACS chemical neuroscience, 2011-02, Vol.2 (2), p.82-89

2011

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Fluoxetine Administered to Juvenile Monkeys: Effects on the Serotonin Transporter and Behavior

American Journal of Psychiatry, 2014-03, Vol.171 (3), p.323-331

2014

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D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model

NeuroImage (Orlando, Fla.), 2010-05, Vol.50 (4), p.1402-1407

2010

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Development of a 18F-labeled PET radioligand for imaging 5-HT1B receptors: [18F]AZ10419096

Nuclear medicine and biology, 2019-11, Vol.78-79, p.11-16

2019

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[11C]AZ10419096 – a full antagonist PET radioligand for imaging brain 5-HT1B receptors

Nuclear medicine and biology, 2017-11, Vol.54, p.34-40

2017

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Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands

The Journal of nuclear medicine (1978), 2010-01, Vol.51 (1), p.112

2010

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In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors

NeuroImage (Orlando, Fla.), 2014-01, Vol.84, p.733

2014

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Retest imaging of [11C]NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans

NeuroImage (Orlando, Fla.), 2014-02, Vol.87, p.89-95

2014

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Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

NeuroImage (Orlando, Fla.), 2009-11, Vol.48 (2), p.362-370

2009

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A facile and regioselective synthesis of rimonabant through an enamine-directed 1,3-dipolar cycloaddition

Tetrahedron letters, 2008-04, Vol.49 (17), p.2789-2791

2008

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A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates

Neuropharmacology, 2016-02, Vol.101, p.519-530

2016

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N-(4-Cyanotetrahydro-2H-pyran-4-yl) and N-(1-Cyanocyclohexyl) Derivatives of 1,5-Diarylpyrazole-3-carboxamides Showing High Affinity for 18 kDa Translocator Protein and/or Cannabinoid Receptors

Journal of medicinal chemistry, 2011-04, Vol.54 (8), p.2961-2970

2011

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Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (6), p.2593-2598

2011

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Synthesis, Ex Vivo Evaluation, and Radiolabeling of Potent 1,5-Diphenylpyrrolidin-2-one Cannabinoid Subtype-1 Receptor Ligands as Candidates for In Vivo Imaging

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5833-5842

2008

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Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors

Nuclear medicine and biology, 2019-03, Vol.70, p.1-13

2019

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Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity

EJNMMI research, 2019-11, Vol.9 (1), p.1-8, Article 100

2019

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Factors That Limit Positron Emission Tomography Imaging of P‑Glycoprotein Density at the Blood–Brain Barrier

Molecular pharmaceutics, 2013-06, Vol.10 (6), p.2222-2229

2013

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N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier

Drug metabolism and disposition, 2010-06, Vol.38 (6), p.917-922

2010

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The PET Radioligand [11C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB1 Receptors in Nonhuman Primate Brain

Neuropsychopharmacology (New York, N.Y.), 2008-01, Vol.33 (2), p.259-269

2008

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Development of radioligands for imaging of brain norepinephrine transporters in vivo with positron emission tomography

Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers

The Inhibitor Ko143 Is Not Specific for ABCG2

Specific in vivo binding to the norepinephrine transporter demonstrated with the PET radioligand, ( S,S)-[ 11C]MeNER

First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B

Serotonin-1A receptors in major depression quantified using PET: Controversies, confounds, and recommendations

The “Specific” P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2)

Fluoxetine Administered to Juvenile Monkeys: Effects on the Serotonin Transporter and Behavior

D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model

Development of a 18F-labeled PET radioligand for imaging 5-HT1B receptors: [18F]AZ10419096

[11C]AZ10419096 – a full antagonist PET radioligand for imaging brain 5-HT1B receptors

Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands

In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors

Retest imaging of [11C]NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans

Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

A facile and regioselective synthesis of rimonabant through an enamine-directed 1,3-dipolar cycloaddition

A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates

N-(4-Cyanotetrahydro-2H-pyran-4-yl) and N-(1-Cyanocyclohexyl) Derivatives of 1,5-Diarylpyrazole-3-carboxamides Showing High Affinity for 18 kDa Translocator Protein and/or Cannabinoid Receptors

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

Synthesis, Ex Vivo Evaluation, and Radiolabeling of Potent 1,5-Diphenylpyrrolidin-2-one Cannabinoid Subtype-1 Receptor Ligands as Candidates for In Vivo Imaging

Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors

Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity

Factors That Limit Positron Emission Tomography Imaging of P‑Glycoprotein Density at the Blood–Brain Barrier

N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier

The PET Radioligand [11C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB1 Receptors in Nonhuman Primate Brain

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