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Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions

Journal of clinical pharmacology, 2016-07, Vol.56 (S7), p.S143-S156

Langer, Oliver

2016

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Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

Contrast media and molecular imaging, 2018-01, Vol.2018, p.3064751-10

2018

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Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment

Neurobiology of disease, 2014-12, Vol.72, p.54-60

2014

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Phase 0/microdosing approaches: time for mainstream application in drug development?

Nature reviews. Drug discovery, 2020-11, Vol.19 (11), p.801-818

2020

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Approaches using molecular imaging technology — use of PET in clinical microdose studies

Advanced drug delivery reviews, 2011-06, Vol.63 (7), p.539-546

2011

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Blood-brain barrier P-glycoprotein function in Alzheimer's disease

Brain (London, England : 1878), 2012-01, Vol.135 (1), p.181-189

2012

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Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study

Journal of cerebral blood flow and metabolism, 2015-05, Vol.35 (5), p.743-746

2015

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A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier

Journal of Nuclear Medicine, 2019-04, Vol.60 (4), p.486-491

2019

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Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.754

2013

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PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

Current drug metabolism, 2011-10, Vol.12 (8), p.774

2011

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Strategic, feasibility, economic, and cultural aspects of phase 0 approaches

Clinical and translational science, 2022-06, Vol.15 (6), p.1355-1379

2022

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Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[11C]verapamil in elderly vs. young subjects

British journal of clinical pharmacology, 2017-09, Vol.83 (9), p.1991-1999

2017

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Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier

Journal of labelled compounds & radiopharmaceuticals, 2013-03, Vol.56 (3-4), p.68-77

2013

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Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice

International journal of molecular sciences, 2022-06, Vol.23 (12), p.6514

2022

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Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy

Current topics in medicinal chemistry, 2010-12, Vol.10 (17), p.1785

2010

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EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

EMBO molecular medicine, 2018-11, Vol.10 (11), p.n/a

2018

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Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

International journal of molecular sciences, 2020-11, Vol.21 (21), p.8245

2020

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P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of 11C-Metoclopramide Across the Blood-Brain Barrier: A PET Study on Nonhuman Primates

The Journal of nuclear medicine (1978), 2018-10, Vol.59 (10), p.1609-1615

2018

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Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET

European journal of nuclear medicine and molecular imaging, 2010-05, Vol.37 (5), p.942-953

2010

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Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

Molecular pharmaceutics, 2018-10, Vol.15 (10), p.4589-4598

2018

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Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling

Alzheimer's research & therapy, 2021-10, Vol.13 (1), p.175-175, Article 175

2021

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ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure

Frontiers in pharmacology, 2021-06, Vol.12, p.698966-698966

2021

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Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [ 11 C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier

Pharmaceutics, 2022-11, Vol.14 (12), p.2650

2022

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Pharmacokinetic Imaging Using 99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

Pharmaceuticals (Basel, Switzerland), 2022-03, Vol.15 (4), p.392

2022

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Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions

Preclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters

Alzheimer’s and ABC transporters — new opportunities for diagnostics and treatment

Phase 0/microdosing approaches: time for mainstream application in drug development?

Approaches using molecular imaging technology — use of PET in clinical microdose studies

Blood-brain barrier P-glycoprotein function in Alzheimer's disease

Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

Strategic, feasibility, economic, and cultural aspects of phase 0 approaches

Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[11C]verapamil in elderly vs. young subjects

Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier

Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice

Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling

Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

P-Glycoprotein (ABCB1) Inhibits the Influx and Increases the Efflux of 11C-Metoclopramide Across the Blood-Brain Barrier: A PET Study on Nonhuman Primates

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET

Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling

ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure

Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [ 11 C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier

Pharmacokinetic Imaging Using 99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

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